Suppressive Effects of Isofraxidin on Depressive-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice

Wu, Xiaoli; Gu, Jingwen; Zou, Zhi-Cong; Yu, Mei; Zhang, Chen; Xiao, Qing; Chen, Xin; Li, Chuwen

doi:10.3390/brainsci12101376

Cited by 8 publications

(7 citation statements)

References 42 publications

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“…There was significantly increased, decreased, or invariant total distance in the model group compared with the control group ( Jeong et al, 2022 ; Wang C. et al, 2022 ; Zhou H. et al, 2022 ). Regarding the center time in OFT, there were also two opposite outcomes ( Jeong et al, 2022 ; Wu et al, 2022 ; Zhou H. et al, 2022 ). Moreover, the center distance was not significantly different in OFT on days 28, 42, and 49 of CUMS ( Liu et al, 2018c ; Jiang et al, 2022 ; Wang G. et al, 2022 ), which was consistent with this study.…”

Section: Discussionmentioning

confidence: 99%

Liuwei Dihuang formula ameliorates chronic stress-induced emotional and cognitive impairments in mice by elevating hippocampal O-GlcNAc modification

Huang

Wang²,

Liu³

et al. 2023

Front. Neurosci.

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A substantial body of evidence has indicated that intracerebral O-linked N-acetyl-β-D-glucosamine (O-GlcNAc), a generalized post-translational modification, was emerging as an effective regulator of stress-induced emotional and cognitive impairments. Our previous studies showed that the Liuwei Dihuang formula (LW) significantly improved the emotional and cognitive dysfunctions in various types of stress mouse models. In the current study, we sought to determine the effects of LW on intracerebral O-GlcNAc levels in chronic unpredictable mild stress (CUMS) mice. The dynamic behavioral tests showed that anxiety- and depression-like behaviors and object recognition memory of CUMS mice were improved in a dose-dependent manner after LW treatment. Moreover, linear discriminate analysis (LEfSe) of genera abundance revealed a significant difference in microbiome among the study groups. LW showed a great impact on the relative abundance of these gut microbiota in CUMS mice and reinstated them to control mouse levels. We found that LW potentially altered the Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) biosynthesis process, and the abundance of O-GlcNAcase (OGA) and O-GlcNAc transferase (OGT) in CUMS mice, which was inferred using PICRUSt analysis. We further verified advantageous changes in hippocampal O-GlcNAc modification of CUMS mice following LW administration, as well as changes in the levels of OGA and OGT. In summary, LW intervention increased the levels of hippocampal O-GlcNAc modification and ameliorated the emotional and cognitive impairments induced by chronic stress in CUMS mice. LW therefore could be considered a potential prophylactic and therapeutic agent for chronic stress.

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Section: Discussionmentioning

confidence: 99%

Liuwei Dihuang formula ameliorates chronic stress-induced emotional and cognitive impairments in mice by elevating hippocampal O-GlcNAc modification

Huang

Wang²,

Liu³

et al. 2023

Front. Neurosci.

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“…In adolescents and children with depression associated with attention deficit and hyperactivity disorder, music therapy increased serotonin secretion and reduced cortisol, blood pressure and heart rate [ 125 ]. In stressed rats, music therapy increased serotonin in the hippocampus and frontal cortex [ 126 ]. It may therefore increase serotonin and reduce anxiety in patients with PE.…”

Section: Discussionmentioning

confidence: 99%

Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review

Leisegang,

Opuwari,

Moichela

et al. 2023

Medicina

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Background and Objectives: Ejaculatory dysfunction (EjD) is a common male sexual disorder that includes premature ejaculation, delayed ejaculation, retrograde ejaculation, and anejaculation. Although psychological and pharmacological treatments are available, traditional, complementary, and alternative medicine (TCAM) is reportedly used. However, the clinical evidence for TCAM in EjD remains unclear. Therefore, this study aims to systematically review human clinical trials investigating the use of TCAM to treat EjD. Materials and Methods: A systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines was conducted by searching Scopus and PubMed databases. Controlled clinical trials investigating a cohort of male patients diagnosed primarily with EjD and undergoing any TCAM intervention compared to any comparison group were included. Quality of the studies was assessed using the Cochrane Risk of Bias tool for randomized controlled trials. Results: Following article screening, 22 articles were included. Of these, 21 investigated TCAM in premature ejaculation, and only 1 investigated TCAM in retrograde ejaculation. Different TCAM categories included studies that investigated lifestyle, exercise and/or physical activities (n = 7); herbal medicine supplements (n = 5); topical herbal applications (n = 4); acupuncture or electroacupuncture (n = 3); vitamin, mineral and/or nutraceutical supplements (n = 1); hyaluronic acid penile injection (n = 1); and music therapy (n = 1). Only 31.8% (n = 7) of the included studies were found to have a low risk of bias. The available studies were widely heterogenous in the TCAM intervention investigated and comparison groups used. However, the included studies generally showed improved outcomes intra-group and when compared to placebo. Conclusions: Different TCAM interventions may have an important role particularly in the management of PE. However, more studies using standardized interventions are needed.

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“…Since NF-κB upregulation is observed in most chronic stress studies, targeting this nuclear factor via natural products used in traditional medicine has been the focus of several in vivo studies. This includes active component extracts like isofraxidin [39], curcumin [40], senegenin [41], helicid [42], trans-Cinnamaldehyde [43], ginkgo [44], and rice germ (RG) [45]; saponins [46,47] and gypenosides [48]; glycosides [49,50]; and flavonoids [51][52][53], in addition to other alkaloids, alcohols, and antioxidants like Berberine [54], geraniol [55], and ferulic acid [56].…”

Section: Nf-κbmentioning

confidence: 99%

“…However, combining fluoxetine treatment with a compound isolated from plants, Lilium [92], cordyceps militaris [93], or an enriched environment [37] may have a synergistic effect. Other compounds isolated from plants have similar effects, including eucommia ulmoides Oliv [49]; saikosaponin-d (SSd), a triterpene saponin [47]; isofraxidin [39]; and β-glucan, a unique agent that has immunomodulatory activity without eliciting a proinflammatory response [94,95].…”

Section: Il-1βmentioning

confidence: 99%

“…Alternative medicine approaches have also decreased IL-6 levels in models of chronic stress. These include the following reagents: prebiotic, Eucommiae cortex polysaccharides (Epss) [73]; rice germ with gamma-aminobutyric acid (GABA) [45]; theanine [45]; isofraxidin [39]; hypericum perforatum [109]; serratula coronate [109]; pumpkin extract [110]; RSNP [111]; crocin-1 [111]; bilobalide [112]; TSPG [113]; and B-glucan pretreatment [94,95]. Therapeutic approaches like acupuncture [85] and enriched environment [37] and transcutaneous vagus nerve stimulation (taVNS) [114] decreased IL-6 in either the AMY, HPC, or serum.…”

Section: Il-6mentioning

confidence: 99%

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Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease

White,

Elias,

Orozco

et al. 2024

IJMS

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The brain is the central organ of adaptation to stress because it perceives and determines threats that induce behavioral, physiological, and molecular responses. In humans, chronic stress manifests as an enduring consistent feeling of pressure and being overwhelmed for an extended duration. This can result in a persistent proinflammatory response in the peripheral and central nervous system (CNS), resulting in cellular, physiological, and behavioral effects. Compounding stressors may increase the risk of chronic-stress-induced inflammation, which can yield serious health consequences, including mental health disorders. This review summarizes the current knowledge surrounding the neuroinflammatory response in rodent models of chronic stress—a relationship that is continually being defined. Many studies investigating the effects of chronic stress on neuroinflammation in rodent models have identified significant changes in inflammatory modulators, including nuclear factor-κB (NF-κB) and toll-like receptors (TLRs), and cytokines, including tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6. This suggests that these are key inflammatory factors in the chronic stress response, which may contribute to the establishment of anxiety and depression-like symptoms. The behavioral and neurological effects of modulating inflammatory factors through gene knockdown (KD) and knockout (KO), and conventional and alternative medicine approaches, are discussed.

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Suppressive Effects of Isofraxidin on Depressive-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice

Cited by 8 publications

References 42 publications

Liuwei Dihuang formula ameliorates chronic stress-induced emotional and cognitive impairments in mice by elevating hippocampal O-GlcNAc modification

Liuwei Dihuang formula ameliorates chronic stress-induced emotional and cognitive impairments in mice by elevating hippocampal O-GlcNAc modification

Traditional, Complementary and Alternative Medicines in the Treatment of Ejaculatory Disorders: A Systematic Review

Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease

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