Suppressive effects of PG201, an ethanol extract from herbs, on collagen-induced arthritis in mice

Shin, Sue; Jin, Myung; Jung, Hye Jung; Kim, Bojeong; Jeon, Hyoju; Choi, Jeewook; Kim, J. M.; Cho, B. W.; Chung, Seung Hyun; Lee, Y. W.; Song, Yong-Bum; Kim, Sun‐Young

doi:10.1093/rheumatology/keg209

Cited by 34 publications

(27 citation statements)

References 26 publications

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“…Rats were assessed daily for signs of arthritis between days 7 and 25 post-CFA using a standard arthritic scoring system (Moudgil et al, 1997;Shin et al, 2003). The maximal arthritic score per rat was set at 16 (maximum of 4 points × 4 paws).…”

Section: Arthritis Assessmentsmentioning

confidence: 99%

“…Moreover, the adverse effects of drug therapy are significant and include gastrointestinal disturbances, infections and cardiovascular risks (Scheiman, 2001;Mangge et al, 2003;Rubbert-Roth and Perniok, 2003;Ortiz, 2004). The inflammatory process of RA is reportedly associated with an increase of the pro-inflammatory cytokines TNF-␣ and IL-1␤ (Dayer, 2003;Fleischmann et al, 2004;Shin et al, 2003). Previous in vitro studies have shown that the boswellic acids derived from Ruxiang, or Gummi olibanum, the dried gum resin of Boswellia carterii Birdw.…”

Section: Introductionmentioning

confidence: 99%

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Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats

Fan

Lao

Zhang

et al. 2005

Journal of Ethnopharmacology

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Section: Arthritis Assessmentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats

Fan

Lao

Zhang

et al. 2005

Journal of Ethnopharmacology

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“…The anti-inflammatory activities of many Chinese herbs have been proved in animal models of arthritis (Shin et al 2003;Chang et al 2005), as well as arthritis patients (Thomsen et al 2005;Liu et al 2007). However, there are still some problems for clinical trials of TCM because of the following reasons: a small population, complex backgrounds, no defined inclusion/exclusion criteria and inadequate statistical analysis so on.…”

Section: Introductionmentioning

confidence: 99%

Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Zhong

Wang

Guo

et al. 2015

Tohoku J. Exp. Med.

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Juvenile idiopathic arthritis (JIA) is the most common arthritis in the adolescents under the age of 16. Etanercept, an inhibitor of tumor necrosis factor, is often used to treat JIA despite its significant side effects. Homeopathic remedies, such as blueberries, have anti-inflammatory properties with fewer unwanted effects and should be considered as a primary treatment. We aimed to explore the efficacy and safety of combination therapy of blueberry and etanercept for JIA. Two hundred and one JIA patients were selected, and randomly and evenly assigned to three groups: ETA (50 mg of etanercept twice weekly), ETABJ (matched etanercept and 50 ml blueberry juice daily) and ETAPJ (matched etanercept and placebo juice). The severity of JIA was measured using American College of Rheumatology scales (ACR) 20, 50 and 70. The levels of pro-inflammatory cytokines, interleukin-1 (IL1) alpha and IL1 beta, and interleukin-1 receptor antagonist (IL1RA) were measured by qRT-PCR and ELISA. After a 6-month follow-up, the ACR20, ACR50 and ACR70 in an ETABJ group were higher than those in other two groups (P < 0.05), suggesting clinically meaningful improvement in JIA. Meanwhile, the symptoms and side effects were reduced significantly or absent in an ETABJ group, including mental diseases, retrobulbar optic neuritis, gaining weight, infection, cutaneous vasculitis, diarrhea, uveitis and pancytopenia. Blueberries reduced the levels of IL1 alpha and beta, and increased the level of IL1RA. Thus, a combination therapy of blueberry and etanercept can reduce the severity of JIA and should be developed as a new method for JIA therapy.

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“…Importantly, therapeutic benefits have been observed in response to the administration of plant-derived molecules for several inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis (MS) (Killestein et al, 2003;Shin et al, 2003;Soeken et al, 2003), providing encouragement for the potential use of these preparations to treat autoimmune disorders. MS is a chronic neuroinflammatory demyelinating disorder of the central nervous system that predominantly affects young adults (Noseworthy et al, 2000).…”

mentioning

confidence: 99%

Andrographolide Interferes with T Cell Activation and Reduces Experimental Autoimmune Encephalomyelitis in the Mouse

Iruretagoyena

Tobar²,

González³

et al. 2004

J Pharmacol Exp Ther

164

108

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Andrographolide is a bicyclic diterpenoid lactone derived from extracts of Andrographis paniculata, a plant indigenous to South Asian countries that shows anti-inflammatory properties. The molecular and cellular bases for this immunomodulatory capacity remain unknown. Here, we show that andrographolide is able to down-modulate both humoral and cellular adaptive immune responses. In vitro, this molecule was able to interfere with T cell proliferation and cytokine release in response to allogenic stimulation. These results were consistent with the observation that T cell activation by dendritic cells (DCs) was completely abolished by exposing DCs to andrographolide during antigen pulse. This molecule was able to interfere with maturation of DCs and with their ability to present antigens to T cells. Furthermore, in vivo immune responses such as antibody response to a thymus-dependent antigen and delayed-type hypersensitivity were drastically diminished in mice by andrographolide treatment. Finally, the ability of andrographolide to inhibit T cell activation was applied to interfere with the onset of experimental autoimmune encephalomyelitis (EAE), an inflammatory demyelinating disease of the central nervous system that is primarily mediated by CD4 ϩ T cells and serves as an animal model for human multiple sclerosis. Treatment with andrographolide was able to significantly reduce EAE symptoms in mice by inhibiting T cell and antibody responses directed to myelin antigens. Our data suggest that andrographolide is able to efficiently block T cell activation in vitro, as well as in vivo, a feature that could be useful for interfering with detrimental T cell responses.

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Suppressive effects of PG201, an ethanol extract from herbs, on collagen-induced arthritis in mice

Abstract: Administration of PG201 has therapeutic effects on CIA. Protection of cartilage was particularly prominent. PG201 is a potential therapy for rheumatoid arthritis.

Cited by 34 publications

References 26 publications

Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats

Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on adjuvant-induced arthritis in lewis rats

Blueberry Improves the Therapeutic Effect of Etanercept on Patients with Juvenile Idiopathic Arthritis: Phase III Study

Andrographolide Interferes with T Cell Activation and Reduces Experimental Autoimmune Encephalomyelitis in the Mouse

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