Suppurative Diseases of the Lung and Pleura: A Continuing Challenge in Developing Countries

Adebonojo, Samuel A.; Grillo, I. A.; Osinowo, O; Adebo, O A

doi:10.1016/s0003-4975(10)63196-7

Cited by 15 publications

(8 citation statements)

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“…11 However, in Nigeria, bronchiectasis accounts for 6% of thoracic surgical problems and remains one of the most common causes of purulent sputum, cough and hemoptysis. 12 The continued high prevalence of bronchiectasis in this population of Alaska Native children, despite control of tuberculosis and vaccine-preventable diseases, appears to be related to the very high rate of severe pneumonias and other LRIs in infants and young children. The most common preceding medical condition in this series was recurrent pneumonia in infancy and early childhood; however, we do not know the rate of recurrent pneumonias in the general population of YK Delta children during the same time period.…”

Section: Discussionmentioning

confidence: 99%

“…This experience with bronchiectasis in YK Delta children more closely resembles that in developing countries, where suppurative infectious diseases of the lung continue to be a great challenge. 12 Thirty-nine (86%) of the bronchiectasis cases were preceded by recurrent pneumonia and/or bronchiolitis. Three patients had culture-proven bacterial pneumonias, and 2 had documented RSV pneumonias.…”

Section: Discussionmentioning

confidence: 99%

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Bronchiectasis in Alaska Native children: Causes and clinical courses

et al. 2000

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bronchiectasis in Alaska Native children: Causes and clinical courses

et al. 2000

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“…Bronchiectasis in childhood is rare in developed countries, except in association with cystic fibrosis and compromised pulmonary host defenses. 1 However, it remains an important cause of morbidity in developing countries 2,3 and among indigenous populations such as Alaska Native children, [4][5][6] Australian Aborigines, 7 and Pacific Islanders. 8 In southwest Alaska Natives, the incidence of bronchiectasis is 16/1,000; 6 in central Australian Aborigines, the incidence is 14/1,000.…”

Section: Introductionmentioning

confidence: 99%

Early radiographic and clinical features associated with bronchiectasis in children

Redding

Singleton

Lewis

et al. 2004

Pediatric Pulmonology

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Bronchiectasis among children living in developing regions is associated with respiratory infections during early childhood, but specific risk factors that precede childhood bronchiectasis are not fully characterized. We hypothesized that severe respiratory syncytial viral (RSV) infection in infancy would increase the risk of bronchiectasis among Alaska Native children in rural Alaska. This was a follow-up cohort study of a 1993-1996 case-control study of RSV-hospitalized case patients and their controls. For each 5-8-year-old former case-patient and control subject, we reviewed medical records, interviewed parents, performed physical examinations and spirometry, collected sera, and analyzed all historical chest radiographs. Ten (11%) RSV cases and 10 (9%) controls had radiographic evidence of bronchiectasis. The mean age at radiographic diagnosis of bronchiectasis was 3.3 years (range, 1.2-6.1 years). Children were more likely to develop bronchiectasis if their chest radiographs, when they were < 2 years of age, showed lung parenchymal densities (RR = 3.9, P < 0.013), persistent parenchymal densities > 6 months' duration (RR = 3.0, P = 0.02), or infiltrates on multiple episodes (test for trend, P = 0.003). Radiographic features of hyperinflation and atelectasis among children < 2 years old were not associated with eventual bronchiectasis. A single severe infection with RSV alone did not predispose Alaska Native infants to bronchiectasis. Childhood bronchiectasis was associated with lung and hence airway injury, manifested on radiographs by parenchymal densities or "pneumonia" rather than by hyperinflation or atelectasis.

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“…(28) No presente trabalho, bronquiectasias como principal diagnóstico representaram 0,4% de todos os diagnósticos de pacientes internados em um hospital especializado em doenças pulmonares, no período de 1978 a 2001. Este é ainda um índice elevado se comparado com os verificados em países mais desenvolvidos.…”

Section: Discussionunclassified

Bronquiectasias: aspectos diagnósticos e terapêuticos Estudo de 170 pacientes

et al. 2003

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INTRODUÇÃO: Bronquiectasias são freqüentemente encontradas na prática médica no Brasil, levando a significativa morbidez e comprometimento da qualidade de vida de seus portadores. OBJETIVOS: Analisar aspectos diagnósticos e terapêuticos em uma série de pacientes com bronquiectasias atendidos em um serviço de doenças pulmonares. MÉTODO: Sinais, sintomas, achados radiográficos e microbiológicos, e resultados terapêuticos foram estudados em 170 pacientes portadores de bronquiectasias hospitalizados no período de 1978 a 2001 - 62,4% do sexo feminino, 37,6% do masculino, com idade média de 37 anos, variando entre 12 e 88 anos. RESULTADOS: Antecedente de pneumonia na infância foi detectado em 52,5% dos pacientes, de tratamento tisiológico em 19,8%; 8,8% tinham asma brônquica, e dois tinham síndrome de Kartagener. Os sintomas mais comuns foram tosse (100%), expectoração (96%) e estertores pulmonares (66%). As lesões eram unilaterais em 46,5% dos casos. Pneumococo, H. influenzae ou flora mista estiveram presentes em 85% das amostras de escarro examinadas. Os 170 pacientes receberam inicialmente tratamento clínico à base de antibióticos e fisioterapia respiratória; 88 deles (52%) mais jovens, com lesões menores e boa reserva funcional foram submetidos à cirurgia de ressecção pulmonar (82 unilaterais e seis bilaterais). Ocorreram dois óbitos hospitalares entre os pacientes que receberam tratamento exclusivamente clínico. Os pacientes tratados cirurgicamente tiveram acentuada melhora dos sintomas, raramente necessitando ser reinternados. CONCLUSÕES: Os prolongados sintomas broncopulmonares foram permanentemente aliviados na maioria dos pacientes com bronquiectasias que puderam ir à cirurgia de ressecção pulmonar, diferentemente dos que seguiram com o tratamento clínico.

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Suppurative Diseases of the Lung and Pleura: A Continuing Challenge in Developing Countries

Cited by 15 publications

References 1 publication

Bronchiectasis in Alaska Native children: Causes and clinical courses

Bronchiectasis in Alaska Native children: Causes and clinical courses

Early radiographic and clinical features associated with bronchiectasis in children

Bronquiectasias: aspectos diagnósticos e terapêuticos Estudo de 170 pacientes

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