Supra-Plasma Expanders

Tsai, Amy G.; Vázquez, Beatriz Y. Salazar; Hofmann, Axel; Acharya, Seetharama A.; Intaglietta, Marcos

doi:10.1097/nan.0000000000000103

Cited by 6 publications

(3 citation statements)

References 42 publications

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“…This effect appears to be independent of the oxygen carrying capacity. A similar effect is hopefully attainable in the future by using plasma expanders that increases plasma viscosity (e.g., polyethylene glycol-conjugated albumin) [ 72 ].…”

Section: Have Transfused Rbcs Increased Oxygen Delivery?mentioning

confidence: 99%

Transfusion of Red Blood Cells to Patients with Sepsis

Chan

Han

et al. 2017

IJMS

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Sepsis is one of the major causes of death worldwide, and is the host response to infection which renders our organs malfunctioning. Insufficient tissue perfusion and oxygen delivery have been implicated in the pathogenesis of sepsis-related organ dysfunction, making transfusion of packed red blood cells (pRBCs) a reasonable treatment modality. However, clinical trials have generated controversial results. Even the notion that transfused pRBCs increase the oxygen-carrying capacity of blood has been challenged. Meanwhile, during sepsis, the ability of our tissues to utilize oxygen may also be reduced, and the increased blood concentrations of lactate may be the results of strong inflammation and excessive catecholamine release, rather than impaired cell respiration. Leukodepleted pRBCs more consistently demonstrated improvement in microcirculation, and the increase in blood viscosity brought about by pRBC transfusion helps maintain functional capillary density. A restrictive strategy of pRBC transfusion is recommended in treating septic patients.

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Section: Have Transfused Rbcs Increased Oxygen Delivery?mentioning

confidence: 99%

Transfusion of Red Blood Cells to Patients with Sepsis

Chan

Han

et al. 2017

IJMS

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“…In shock, flow can be significantly impaired and reduced dramatically, resulting in inadequate tissue oxygenation. Thus, increasing the intravascular microcirculatory volume via resuscitation fluid will enhance flow and tissue (re)oxygenation (67). Regardless of the mechanism for reperfusion, microvascular recovery following shock is contingent on how well oxygen delivery to previously hypoxic tissues can be achieved.…”

Section: Microvascular Flowmentioning

confidence: 99%

Resuscitation After Hemorrhagic Shock in the Microcirculation: Targeting Optimal Oxygen Delivery in the Design of Artificial Blood Substitutes

et al. 2020

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“…Plasma expanders have been used in emergent transfusion for serious blood and fluid loss, circulation stabilization, and blood dilution. , Crystalloid solutions (e.g., stroke-physiological saline solution) and colloid solutions (e.g., dextran, gelatin, albumin, and hydroxyethyl starch (HES)) have been clinically used as plasma expanders. , Compared with crystalloid solutions, colloid solutions effectively maintain the functional capillary density and expand the blood volume and osmotic pressure thereby improving the microcirculation of tissues in hemorrhagic shock. , …”

Section: Introductionmentioning

confidence: 99%

Hydroxyethyl Starch–Bovine Hemoglobin Conjugate as an Effective Oxygen Carrier with the Ability to Expand Plasma

et al. 2023

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Hemorrhagic shock leads to intravasal volume deficiency, tissue hypoxia, and cellular anaerobic metabolism. Hemoglobin (Hb) could deliver oxygen for hypoxic tissues but is unable to expand plasma. Hydroxyethyl starch (HES) could compensate for the intravasal volume deficiency but cannot deliver oxygen. Thus, bovine Hb (bHb) was conjugated with HES (130 kDa and 200 kDa) to develop an oxygen carrier with the ability to expand plasma. Conjugation with HES increased the hydrodynamic volume, colloidal osmotic pressure, and viscosity of bHb. It slightly perturbed the quaternary structure and heme environment of bHb. The partial oxygen pressures at 50% saturation ( P 50 ) of the two conjugates (bHb-HES130 and bHb-HES200) were 15.1 and 13.9 mmHg, respectively. The two conjugates showed no apparent side effects on the morphology and rigidity, hemolysis, and platelet aggregation of red blood cells of Wistar rats. Thus, bHb-HES130 and bHb-HES200 were expected to function as an effective oxygen carrier with the ability to expand plasma.

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Supra-Plasma Expanders

Cited by 6 publications

References 42 publications

Transfusion of Red Blood Cells to Patients with Sepsis

Transfusion of Red Blood Cells to Patients with Sepsis

Resuscitation After Hemorrhagic Shock in the Microcirculation: Targeting Optimal Oxygen Delivery in the Design of Artificial Blood Substitutes

Hydroxyethyl Starch–Bovine Hemoglobin Conjugate as an Effective Oxygen Carrier with the Ability to Expand Plasma

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