Supraglottic Carcinoma Treated with Curative Radiation Therapy: Identification of Prognostic Groups with MR Imaging

Abstract

MR imaging-determined pre-epiglottic space involvement and abnormal signal intensities in the thyroid cartilage adjacent to the anterior commissure and/or the cricoid cartilage are strong predictors of local outcome in supraglottic carcinoma treated with definitive radiation therapy.

Single-Shot Turbo Spin-Echo Diffusion-Weighted Imaging for Retinoblastoma: Initial Experience

“…The reduced sensitivity to susceptibility artifacts of HASTE DWI is especially important in retinoblastoma, because this tumor usually contains multiple foci of calcifications and the mean tumor volume in retinoblastoma is usually small (approximately 1 cm 3 ) compared with other primary tumors in the head and neck (approximately 7-10 cm 3 ). [17][18][19] By using a relatively high spatial resolution, even small intraocular lesions could be detected on ADC maps.…”

Has the Degree of Contrast Enhancement with MR Imaging in Laryngeal Carcinoma Added Value to Anatomic Parameters Regarding Prediction of Response to Radiation Therapy?

“…22,23 In accordance with previous studies, tumor involvement to the PES in supraglottic carcinoma is a strong independent prognostic factor for the tumor recurrence. 10,[24][25][26] The low degree of contrast enhancement in this study may therefore be expected in patients with tumor involvement to the PES and may correlate with a poor prognosis (Fig 4).…”

“…The previously considered MR imaging parameters, such as tumor involvement of specific laryngeal anatomic subsites, including laryngeal cartilages, tumor volume, and extralaryngeal tumor spread, have already been evaluated. 10 The main purpose of the present study was to retrospectively investigate the prognostic significance of the degree of contrast enhancement in tumors and its additional value in previously considered MR imaging parameters, with regard to local control of laryngeal cancer treated with RT alone.…”

The impact of preepiglottic space invasion on cervical lymph node metastases in open supraglottic laryngectomy revisited

“…Thus to overcome the understaging problem in patients with suspected PES invasion, different imaging modalities are used. [4,16,20,21] Hermans et al [16] investigated the value of computed tomography (CT) by assessing several tumor parameters and their clinical importance on locoregional outcomes after primary radiotherapy for laryngeal carcinoma. They found that the degree of PES involvement on CT was a significant independent predictor of local recurrence.…”

“…Pre-treatment magnetic resonance imaging (MRI) is a good and reliable alternative to CT in the determination of prognostic risk factors for locoregional control. Ljumanović et al [20] pointed out that PES invasion diagnosed by MRI in patients who underwent definitive radiotherapy for supraglottic carcinoma was a significant predictor of local control rates. Becker et al [21] reviewed the efficacy of three commonly used modalities--CT, MRI and positron emission tomography (PET)/CT in the diagnostic work-up of laryngeal structures including PES that are relevant to tumor spread.…”