Supramolecular hydrogels as drug delivery systems

Saboktakin, Mohammad Reza; Tabatabaei, Roya Mahdavi

doi:10.1016/j.ijbiomac.2015.02.006

Cited by 91 publications

(34 citation statements)

References 56 publications

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“…Hydrogels, ac lass of water-swollen crosslinked polymericm aterials with characteristict hree-dimensional network structuresa re of increasing interestb ecause of their unique properties and potential applications in drug delivery, tissue engineering, woundd ressing, and cell immobilization. [62][63][64][65][66][67] The cross-linked structures of supramolecular hydro-gels or physical gels are derived from non-covalenti nteraction between macrocyclic host molecules and polymericg uest molecules. These gels are fascinating materials for applications in the biomedical field because of their response to stimuli.…”

Section: Supramolecular Hydrogels Induced By Host-guest Interactionmentioning

confidence: 99%

Emerging Supramolecular Therapeutic Carriers Based on Host–Guest Interactions

Karim

Dou

Liu

et al. 2016

Chemistry An Asian Journal

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Recent advances in host–guest chemistry have significantly influenced the construction of supramolecular soft biomaterials. The highly selective and non‐covalent interactions provide vast possibilities of manipulating supramolecular self‐assemblies at the molecular level, allowing a rational design to control the sizes and morphologies of the resultant objects as carrier vehicles in a delivery system. In this Focus Review, the most recent developments of supramolecular self‐assemblies through host–guest inclusion, including nanoparticles, micelles, vesicles, hydrogels, and various stimuli‐responsive morphology transition materials are presented. These sophisticated materials with diverse functions, oriented towards therapeutic agent delivery, are further summarized into several active domains in the areas of drug delivery, gene delivery, co‐delivery and site‐specific targeting deliveries. Finally, the possible strategies for future design of multifunctional delivery carriers by combining host–guest chemistry with biological interface science are proposed.

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Section: Supramolecular Hydrogels Induced By Host-guest Interactionmentioning

confidence: 99%

Emerging Supramolecular Therapeutic Carriers Based on Host–Guest Interactions

Karim

Dou

Liu

et al. 2016

Chemistry An Asian Journal

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“…Solution crystallization is widely used in the production of pharmaceutical crystals. During the crystallization of active pharmaceutical ingredients (APIs) under various conditions, several studies have reported the occurrence of gelation phenomenon [1,2]. Gelation of some APIs, such as clopidogrel sulfate [3] and valsartan [4], is rather likely to form a gel-like phase in their supersaturated state, which is an unwanted process in industrial crystallization.…”

Section: Introductionmentioning

confidence: 99%

Gelation Mechanism of Erythromycin Ethylsuccinate During Crystallization

Gao

Bao

et al. 2018

Trans. Tianjin Univ.

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In this paper, the gelation mechanism of erythromycin ethylsuccinate (EES) during crystallization is investigated for the first time. The generated semisolid gel-like phase exhibited a 3D fibrillar network morphology and the typical rheological properties of gels. The fibers inside the gel-like phase were confirmed to be new types of EES solvates using powder X-ray diffraction, thermogravimetric analysis/differential scanning calorimetry, and gas chromatography. The gelation and crystallization regions in EES-1-propanol solid-liquid phase diagram were determined. Analyses of solvent parameters showed that moderate solvent polarity may promote EES gelation. Fourier transform infrared spectra, nuclear magnetic resonance spectra, and scanning electron microscopy analyses indicated that through intermolecular hydrogen bonds, EES and solvent molecules assembled into fibers via crystallographic mismatch branching growth. The fibers intertwined into a 3D network microstructure and formed a gel-like phase, completely immobilizing the solution.

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“…Without interpreting ethical issues, treatment of impaired nephrogenesis in a preterm infant principally could be implemented either by selected morphogens and related molecules using an innovative drug delivery system [12] or by an implantation of stem/ progenitor cells into the subcapsular space of the kidney [13]. Con-sequently, detailed knowledge is required about the distribution of an administered drug in the nephrogenic zone, binding on locally existing extracellular matrix, bioavailability on the site of niches, reaction on the target, metabolism and possible embryo-toxic side effects on neighboring maturing parenchyma.…”

Section: Introductionmentioning

confidence: 99%

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2017

Drug Res (Stuttg)

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Supramolecular hydrogels as drug delivery systems

Cited by 91 publications

References 56 publications

Emerging Supramolecular Therapeutic Carriers Based on Host–Guest Interactions

Emerging Supramolecular Therapeutic Carriers Based on Host–Guest Interactions

Gelation Mechanism of Erythromycin Ethylsuccinate During Crystallization

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