Supramolecular phenoxy-alkyl maleate-based hydrogels and their enzyme/pH-responsive curcumin release

Abstract

Low molecular-weight hydrogelators as stimuli-responsive drug carrier agents in the pharmaceutical field.

Supramolecular Glycolipid-Based Hydro-/Organogels with Enzymatic Bioactive Release Ability by Tuning the Chain Length and Headgroup Size

“…It may be observed in Figure that hydrogel 22M-W exhibited the maximum storage modulus, while 16M-W had the lowest storage modulus value. In organogels ( 12D-H and 16D-H ), with an increase in chain length, the gel strength also increased . Similarly, with an increase in chain length of fatty acid amides of natural amino acids from C10 to C14, an increase in yield stress from 12 to 40 Pa was reported .…”

“…Gels are proven to be excellent carrier systems in the biomedical field. Encapsulation of bioactives inside the self-assembled gel network of amphiphilic molecules has been extensively studied. , Enzyme- and pH-responsive drug release behavior of supramolecular phenoxy-alkyl maleate-based hydrogels was studied by encapsulating the hydrophobic curcumin drug inside the gel network . Supramolecular hydrogel-based drug delivery systems have found medical use with therapeutic outcomes.…”

Recent Updates on Supramolecular‐Based Drug Delivery – Macrocycles and Supramolecular Gels

“…reported enzymatically cleavable and pH‐responsive hydrogels based on phenoxy‐alkyl maleate‐based amphiphiles where the entrapped hydrophobic drug was released via the enzyme‐assisted hydrolysis of the ester bond. Moreover, the curcumin‐trapped hydrogel presented efficient release at acidic pH within 55 min [112] …”

“…hydrogel presented efficient release at acidic pH within 55 min. [112] Significantly higher number of recent reviews are available on applications of dendrimers in drug delivery. [113] Reviews specific to brain targeting, [114a] pulmonary delivery, [114b] cancer therapy, [114c,d] and ocular delivery [114e,f] could be found.…”

Advances in smart delivery of food bioactive compounds using stimuli‐responsive carriers: Responsive mechanism, contemporary challenges, and prospects

“…In a recent study, the phenoxy-alkyl maleate-based hydrogel was produced via non-covalent interactions for controlled-release of Cur which was entrapped in the hydrophobic pockets of the hydrogel. The ester bond between phenoxy alkanol and maleic anhydride in the hydrogel could be hydrolyzed by lipozyme or in acidic condition, leading to gel degradation and core release (Kumar & Nayak, 2019). Likewise, pH/esterase dual-responsive nanoparticles were synthesized for the delivery of active molecule-active molecule conjugates (Cur-oxoplatin) from β-cyclodextrin-modified hyaluronic acid (HA-β-CD), which self-assembled through supramolecular interactions.…”