Supramolecular polymeric prodrug micelles for efficient anticancer drug delivery

Abstract

Polymeric prodrugs have attracted great interest in the field of antitumor drug delivery owing to its integrated advantages of prodrugs and nanoparticles. However, the ambiguous chemical composition of polymeric prodrugs...

Supramolecular Biopharmaceutical Carriers Based on Host–Guest Interactions

“…For traditional drug carriers, there are organic nanocarriers, inorganic nanocarriers and other forms. − Although inorganic nanocarriers such as silica and metal oxides have high drug loading capacity, tunable surface modifications, and adjustable size strategies, they are difficult to degrade in vivo, toxic and cause damage to normal human cells, limiting their application in pharmacology. For organic nanocarriers, e.g., liposomal drug formulations exhibit higher biocompatibility and fewer side effects in clinical practice, and for some metal frameworks with high porosity, drug loading is high and stable, but high stability of drug loading usually signifies slow drug release, leading to an under accumulation of the drug at the target site. − Thus, treatment failure or even multidrug resistance (MDR) seriously impedes the practical application of organic carriers in anticancer drug delivery. , Previous studies have focused on improving the dissolution stability of drugs with poor solubility by improving the drug itself, adding other substances to improve the shortcomings of the drug itself, and noncovalent binding to other substances. However, there is a certain degree of innovation and advancement in the method of fundamental improvement of the drug itself through the combination of supramolecular host and guest drugs.…”

“…7−9 Thus, treatment failure or even multidrug resistance (MDR) seriously impedes the practical application of organic carriers in anticancer drug delivery. 10,11 Previous studies have focused on improving the dissolution stability of drugs with poor solubility by improving the drug itself, adding other substances to improve the shortcomings of the drug itself, and noncovalent binding to other substances. However, there is a certain degree of innovation and advancement in the method of fundamental improvement of the drug itself through the combination of supramolecular host and guest drugs.…”

Size control of copper nanodrugs through emulsion atom transfer radical polymerization

“…To maintain system stability without co-stabilizers, poly(ethylene glycol) methyl ether acrylate (mPEG-acrylate) with a number average molecular weight (M n ) of 5000 Da was chosen as the hydrophilic component and emulsifier. 30 Poly(ethylene glycol) (PEG) is the most vital component used in polymeric nanodrugs because of its anti-fouling properties, biocompatibility, and low toxicity, [31][32][33][34] and the polymerizable carbon-carbon double bond at the chain end makes it possible for the PEG unit to be copolymerized with other hydrophobic monomers to form nanoparticles. [35][36][37] Besides, using mPEG-acrylate as the macromonomer ensured that each synthesized polymer chain incorporated several PEG units, further stabilizing the nanoparticles through the steric effect provided by mPEG-acrylate.…”

Degradable polymers with adjustable thermoresponsiveness based on multicomponent polymerization and molecular recognition

“…The adamantyl groups can form supramolecular complexes with β-cyclodextrin (β-CD) derivatives through noncovalent hostguest interaction, which has been applied in polymer modification and property adjustment. [16][17][18][19][20] After recognition of hydrophilic β-CD derivatives, the hydrophobic adamantyl groups on the thermoresponsive polymers are covered by hydrophilic groups, which effectively adjusts the hydrophilichydrophobic balance of the polymers and regulates the LCST. Since hydrophilic β-CD derivatives are soluble in water, a simple mixture of them with adamantyl group-modified thermoresponsive polymers can form supramolecular complexes and lead to LCST change.…”