Supramolecular vesicles based on pillar[<i>n</i>]arenes: design, construction, and applications

Xiao, Tangxin; Zhong, Weiwei; Xu, Lixiang; Sun, Xiaoqiang; Hu, Xiao‐Yu; Wang, Leyong

doi:10.1039/c8ob03095b

Cited by 68 publications

(35 citation statements)

References 94 publications

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“…The clinical efficacy and outcome of conventional molecular chemotherapeutics against tumors are limited by several undesirable properties, including the poor solubility, the short half-life in vivo , the weak penetration capability, and the low specificity (Tang et al, 2014 ; Liu et al, 2016 ; Wang et al, 2017 , 2018 ; Luo et al, 2019 ). To overcome these drawbacks of conventional cancer chemotherapeutics, various nanoparticle-based drug delivery systems (DDSs) have been developed (Versluis et al, 2016 ; Gerbelli et al, 2019 ; Xiao et al, 2019b ). Ingeniously designed DDSs can improve the bioavailability of drugs and/or minimize the adverse effects of drugs on normal tissues (Liu et al, 2016 ; Wang et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Tumor Microenvironment–Responsive Peptide-Based Supramolecular Drug Delivery System

Zhang

et al. 2020

Front. Chem.

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Physical and biochemical differences between tumor tissues and normal tissues provide promising triggering factors that can be utilized to engineer stimuli-responsive drug delivery platforms for cancer treatment. Rationally designed peptide-based supramolecular architectures can perform structural conversion by responding to the tumor microenvironment and achieve the controlled release of antitumor drugs. This mini review summarizes recent approaches for designing internal trigger-responsive drug delivery platforms using peptide-based materials. Peptide assemblies that exhibit a stimuli-responsive structural conversion upon acidic pH, high temperature, high oxidative potential, and the overexpressed proteins in tumor tissues are emphatically introduced. We also discuss the challenges of current peptide-based supramolecular delivery platforms against cancer.

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Section: Introductionmentioning

confidence: 99%

Tumor Microenvironment–Responsive Peptide-Based Supramolecular Drug Delivery System

Zhang

et al. 2020

Front. Chem.

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“…21,22 Currently, a variety of amphiphilic molecules have been used in the fabrication of vesicles; moreover, amphiphilic host molecules are particularly promising for vesicle construction because of their unique dynamic reversibility, which has led to the emergence of supramolecular vesicles. [23][24][25] Supramolecular vesicles obtained through host-guest interactions have attracted much attention as SDDs because of their smart responsiveness to stimuli.…”

Section: Introductionmentioning

confidence: 99%

<p>Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery</p>

Hua¹,

Chen²,

Hou³

et al. 2020

IJN

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Supramolecular vesicles are the most popular smart nano-drug delivery systems (SDDs) because of their unique cavities, which have high loading carrying capacity and controlled-release action in response to specific stimuli. These vesicles are constructed from amphiphilic molecules via host-guest complexation, typically with targeted stimuli-responsive units, which are particularly important in biotechnology and biomedicine applications. Amphiphilic pillar[n]arenes, which are novel and functional macrocyclic host molecules, have been widely used to construct supramolecular vesicles because of their intrinsic rigid and symmetrical structure, electron-rich cavities and excellent properties. In this review, we first explain the synthesis of three types of amphiphilic pillar[n]arenes: neutral, anionic and cationic pillar[n]arenes. Second, we examine supramolecular vesicles composed of amphiphilic pillar[n] arenes recently used for the construction of SDDs. In addition, we describe the prospects for multifunctional amphiphilic pillar[n]arenes, particularly their potential in novel applications.

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“…Currently, in the eld of drug delivery systems (DDSs), there is growing interest in developing smart carriers with various functionalities, such as pH-, electric-, magnetic-, temperature-, and light-sensitive carriers. [1][2][3][4][5][6][7] Among them, light is regarded as the most desirable stimulus as it offers the unique properties of clean control, contactless perturbation and excitation tunability. Many reports are available on an azobenzene (Az), the conformation of which (linear trans-and bent cis-isomers) can be reversibly switched by exposure to specic wavelengths, triggering the release behaviour of light-sensitive carriers.…”

Section: Introductionmentioning

confidence: 99%

Self-assembly of photoresponsive azo-containing phospholipids with a polar group as the tail

Kurihara

Tomimori

et al. 2020

RSC Adv.

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Supramolecular vesicles based on pillar[n]arenes: design, construction, and applications

Abstract: Recent progress in supramolecular vesicles based on pillar[n]arenes is reviewed.

Cited by 68 publications

References 94 publications

Tumor Microenvironment–Responsive Peptide-Based Supramolecular Drug Delivery System

Tumor Microenvironment–Responsive Peptide-Based Supramolecular Drug Delivery System

<p>Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery</p>

Self-assembly of photoresponsive azo-containing phospholipids with a polar group as the tail

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