Supratentorial Ependymomas in Adult Patients

Schwartz, Theodore H.; Kim, Samuel; Glick, Rachel S.; Bagiella, Emilia; Balmaceda, Casilda; Fetell, Michael R.; Stein, Bennett M.; Sisti, Michael B.; Bruce, Jeffrey N.

doi:10.1097/00006123-199904000-00018

Cited by 114 publications

(110 citation statements)

References 45 publications

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“…5,9,12,18,19,34 For this analysis, confounding factors included the unreliability of surgical assessment of the degree of ablation 35 and differences in the composition of compared groups with respect to age, performance status, and tumor grade, site, and size. In the current series, as in previous studies, 15,16 no statistically significant difference in overall survival was observed on univariate or multivariate analysis. Extent of resection was predictive of TTF.…”

Section: Prognostic Factorssupporting

confidence: 82%

“…9,10,15,16,18,19 The findings in the current study (5-year OS, 67%; 10-year OS, 50%) were similar. Results also were comparable with respect to 5-and 10-year FFS rates, which were 43% and 24%, respectively, in the current series and 42-55% and 27-43%, respectively, in the literature.…”

Section: Prognostic Factorssupporting

confidence: 77%

“…Thus, we believe that it is prudent to report results from adult and pediatric populations separately. Recently, a small number of original articles and a review article have contributed to the body of knowledge regarding adult intracranial ependymal tumors, [15][16][17][18] and the current article further addresses this topic.…”

Section: Discussionmentioning

confidence: 99%

“…Results also were comparable with respect to 5-and 10-year FFS rates, which were 43% and 24%, respectively, in the current series and 42-55% and 27-43%, respectively, in the literature. 10,15,16,18 The possible correlation between tumor grade and survival is controversial, 5,9,11,12,18,20 -22 with differences in findings probably being attributable to sample size, anatomic tumor location, variability in the definition of anaplasia, [23][24][25] discrepancies in histologic diagnoses, 26 and the inclusion in some series of ependymoblastoma and subependymoma, which exhibit different biologic behavior and should be analyzed separately. Anaplastic ependymoma is even less common in the adult population, accounting for approximately 20% of all ependymal tumors in the current series; this figure is consistent with previously reported rates of 17-28%.…”

Section: Prognostic Factorsmentioning

confidence: 99%

“…Anaplastic ependymoma is even less common in the adult population, accounting for approximately 20% of all ependymal tumors in the current series; this figure is consistent with previously reported rates of 17-28%. 4,9,16,27,28 Due to the limited sample size, solid conclusions regarding survival differences between patients with Grade 2 ependymal tumors and those with Grade 3 ependymal tumors could not be made. In other series, histology was not assessed 16 or was found to be a significant independent predictor of survival only on univariate analysis, 15 which prevented any firm conclusions from being made, due to differences between compared groups in terms of the distribution of prognostic factors.…”

Section: Prognostic Factorsmentioning

confidence: 99%

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A multicenter study of the prognosis and treatment of adult brain ependymal tumors

Reni

Brandes

Vavassori

et al. 2004

Cancer

107

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BACKGROUNDThe current analysis of outcomes in a large series of adult patients with intracranial ependymal tumors contributes to the characterization of the primary prognostic factors and to the therapeutic management of this rare disease, for which limited information is available in the literature.METHODSThe authors analyzed data on patient and tumor characteristics, treatment, and survival in a series of 70 patients age > 17 years with pathologic diagnoses of brain ependymal tumors from 4 institutions.RESULTSThe 5‐ and 10‐year overall survival (OS) rates (± standard errors) were 67% ± 6% and 50% ± 8%, respectively. The 5‐ and 10‐year failure‐free survival (FFS) rates were 43% ± 7% and 24% ± 6%, respectively. Younger age and infratentorial tumor location were associated with longer survival. Among patients with Grade 2 ependymoma (n = 51), 21 (41%) received no postsurgical treatment. These 21 patients had a 5‐year OS rate of 78% ± 10% and a 10‐year OS rate of 68% ± 13%; the 5‐ and 10‐year FFS rates for these patients were 47% ± 12% and 12% ± 11%, respectively. Twenty‐six patients with Grade 2 ependymoma (51%) received postoperative radiotherapy (RT). These 26 patients had a 5‐year OS rate of 71% ± 9% and a 10‐year OS rate of 59% ± 11%; the 5‐ and 10‐year FFS rates for these patients were 54% ± 10% and 34% ± 10%, respectively. Among patients with Grade 2 ependymoma, neither OS nor FFS differed significantly between those who did not receive postoperative RT and those who did; however, these two groups were heterogeneous with respect to prognostic factors. On multivariate analysis, RT use exhibited a trend toward improved OS and was significantly predictive of improved FFS.CONCLUSIONSThe current analysis does not rule out the possibility that deferral of RT at the time of recurrence could have a detrimental effect on FFS or OS in patients with Grade 2 ependymoma, regardless of the degree of ablation. The role of postoperative RT for patients who undergo imaging‐based macroscopic total resection remains to be addressed. Cancer 2004. © 2004 American Cancer Society.

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Section: Prognostic Factorssupporting

confidence: 82%

Section: Prognostic Factorssupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Prognostic Factorsmentioning

confidence: 99%

Section: Prognostic Factorsmentioning

confidence: 99%

See 3 more Smart Citations

A multicenter study of the prognosis and treatment of adult brain ependymal tumors

Reni

Brandes

Vavassori

et al. 2004

Cancer

107

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Ependymomas

Rudà

Gilbert

Soffietti

2017

Textbook of Uncommon Cancer

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Supratentorial extraventricular ependymal neoplasms

Shuangshoti

Rushing

Mena

et al. 2005

Cancer

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Objective Transient amnesia can be the principal manifestation of epilepsy. This diagnosis, however, is seldom suspected by clinicians and remains controversial. The amnestic attacks are often associated with persistent memory complaints. This study was designed to provide the first description of transient epileptic amnesia in a substantial series of patients. Methods Fifty patients were recruited over 18 months using the following diagnostic criteria: (1) recurrent, witnessed episodes of amnesia; (2) other cognitive functions intact during attacks; and (3) compelling evidence of epilepsy. We assessed clinical features and performed neuropsychological evaluation in cases and 24 matched control subjects. Results Transient epileptic amnesia develops in later life (mean onset, 62 years). Amnestic episodes are frequent (median, 12/year), brief (median duration, 30–60 minutes), and often occur on waking (37/50 cases). Epilepsy was the initial specialist diagnosis in only 12 of 50 cases. Attacks ceased on anticonvulsant medication in 44 of 47 treated patients. A total of 40 of 50 cases described persistent memory difficulties. Despite normal performance on standard memory tests, patients exhibited accelerated forgetting of verbal and visual material over 3 weeks by comparison with matched control subjects (p < 0.001). They also showed loss of autobiographical memories for events extending back over 40 years (p < 0.05). Interpretation We propose that transient epileptic amnesia is a distinctive epilepsy syndrome, typically misdiagnosed at presentation and associated with accelerated long‐term forgetting and autobiographical amnesia. The syndrome is of clinical and theoretic importance. Ann Neurol 2007

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Supratentorial Ependymomas in Adult Patients

Cited by 114 publications

References 45 publications

A multicenter study of the prognosis and treatment of adult brain ependymal tumors

A multicenter study of the prognosis and treatment of adult brain ependymal tumors

Ependymomas

Supratentorial extraventricular ependymal neoplasms

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