Supratentorial intracerebral cerebellar liponeurocytoma

Abstract

Rationale:Cerebellar liponeurocytoma is a rare tumor of the central nervous system (CNS) characterized by low proliferation but high likelihood of recurrence. Because of its rarity and the paucity of systematic follow-up, the biological behaviors and clinical features of this tumor are still poorly understood. We herein reported a case of cerebellar liponeurocytoma originating in the cerebral hemisphere.Patient concerns:A 11-year-old male with intermittent headache, nausea, and vomiting. The first computed tomography revealed a large mass in the right cerebral hemisphere. He was transferred to our institution for neurosurgical treatment.Diagnosis:Magnetic resonance imaging showed a large cystic—solid mass in the right frontal lobe with obvious contrast enhancement. Histopathological examinations showed sheets of isomorphic small neoplastic cells with clear cytoplasm and focal lipomatous differentiation. On immunohistochemistry, tumor cells were positive for synaptophysin, microtubule-associated protein 2, and neuronal nuclei antigen.Interventions:The patient was performed a right fronto-parietal craniotomy, and gross total resection of the tumor was achieved without adjuvant therapy.Outcomes:No clinical or neuroradiological evidence of recurrence or residual of the tumor was found 6 years and 2 months after initial surgery.Lessons:Cerebellar liponeurocytoma developing in supratentorial cerebral hemisphere was first reported in the present study. The radiological and histopathological features may be useful in differentiating this rare tumor from other tumors at similar locations. A change in the nomenclature of cerebellar liponeurocytomas should be considered in future World Health Organization (WHO) classifications.

Cerebellar Liponeurocytoma Presenting with Fatal Tumor Hemorrhage

“…After left cerebellar corticotomy a large reddish tumor [5-8], 14 in the supratentorial ventricular system [9,10], one in the cerebellopontine angle [11] and one in the cerebral parenchyma [12], as evidenced by some literature reviews [10,[12][13][14][15][16]. We agree with Cai et al [12] that the definition of "central liponeurocytoma" is more appropriate than "cerebellar liponeurocytoma" for including the different reported sites. Almost all reported cases were observed in patients from 30 to 60-years-old, with no sex difference.…”

Cerebellar Liponeurocytoma: A Rare Fatty Tumor and its Literature Review

“…[8] Recent reports also exist in the form of individual cases, the most common being in the infratentorial location. [910111213] Gembruch et al ., in a systematic review of all the reported cases ( n = 73) until 2018, noted that these tumors had low MIB-1 proliferation index (3.73 ± 4.01%). [14] Of the infratentorial location, the cerebellar hemisphere is the most common location.…”

Cerebellar liponeurocytoma, a rare tumor: Case report and review of the literature

“…This kind of disease also shows a monotonous pattern of isomorphic round to oval cells with focal accumulations of lipid-laden cells, that, at the same time, they seem to be neuroepithelial tumor cells with lipid accumulation or they constitute a form of lipidization instead of true adipose cells [ 11 , 12 ].…”

“…Usually, the symptoms that are present with this condition are headache, vomiting, nausea and dizziness, as well as ataxia with unsteadiness and frequent falls. A flow obstruction of the cerebrospinal fluid can also be seen [ [11] , [12] , [13] ].…”