Supratentorial primary intra-axial tumors in children

Higano, Shuichi; Takahashi, Satoshi; Kurihara, Noriko; Ishii, Kiyoshi; Matsumoto, Katsutoshi; Shirane, Reizo; Katakura, Ryuichi; Singh, L. N.; Yamada, S.

doi:10.1080/02841859709172108

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…A novel MRI phantom containing calcium and iron deposits supported our hypothesis that calcified regions produce a signal change in T1W images that allows them to be differentiated from deposits where iron is prevalent; both are known to appear hypointense on T2*W images. These results are in agreement with studies that had histological confirmation, two of which reported that calcium and other minerals appear hyperintense on T1W (24,30), three studies that reported that calcium and hemosiderin appear hypointense on T1W (31)(32)(33), and other three studies, which reported that noncalcified regions appear isointense on T1W (34)(35)(36).…”

Section: Discussionsupporting

confidence: 91%

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Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images

Hernández

Glatz

Kiker

et al. 2013

Magnetic Resonance Imaging

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Purpose: In the human brain, minerals such as iron and calcium accumulate increasingly with age. They typically appear hypointense on T2*-weighted MRI sequences. This study aims to explore the differentiation and association between calcified regions and noncalcified iron deposits on clinical brain MRI in elderly, otherwise healthy subjects. Materials and Methods:Mineral deposits were segmented on co-registered T1-and T2*-weighted sequences from 100 1.5 Tesla MRI datasets of community-dwelling individuals in their 70s. To differentiate calcified regions from noncalcified iron deposits we developed a method based on their appearance on T1-weighted images, which was validated with a purpose-designed phantom. Joint T1-and T2*-weighted intensity histograms were constructed to measure the similarity between the calcified and noncalcified iron deposits using a Euclidean distance based metric.Results: We found distinct distributions for calcified regions and noncalcified iron deposits in the cumulative joint T1-and T2*-weighted intensity histograms across all subjects (correlations ranging from 0.02 to 0.86; mean ¼ 0.26 6 0.16; t ¼ 16.93; P < 0.001) consistent with differences in iron and calcium signal in the phantom. The mean volumes of affected tissue per subject for calcified and noncalcified deposits were 236.74 6 309.70 mm 3 and 283.76 6 581.51 mm 3 ; respectively. There was a positive association between the mineral depositions (b ¼ 0.32, P < 0.005), consistent with existing literature reports. Conclusion:Calcified mineral deposits and noncalcified iron deposits can be distinguished from each other by signal intensity changes on conventional 1.5T T1-weighted MRI and are significantly associated in brains of elderly, otherwise healthy subjects.

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Section: Discussionsupporting

confidence: 91%

“…The resulting intracranial volume (ICV) masks were visually checked and corrected when necessary following the procedure described in (23) and further applied to the T1W sequence. The extracted brains from the T1W and T2*W sequences were bias-field corrected using N4 (24).…”

Section: Preprocessingmentioning

confidence: 99%

Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images

Hernández

Glatz

Kiker

et al. 2013

Magnetic Resonance Imaging

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“…Among the supratentorial tumors, extraaxial tumors predominated with 51.98% which is attributed to the greater proportion of craniopharyngiomas (25%)[ 26 ] and extraaxial location of six cases of pilocytic astrocytomas (11.53%).…”

Section: Discussionmentioning

confidence: 99%

Histomorphological spectrum of pediatric supratentorial CNS tumors: A 3-year retrospective study in a tertiary care center

Rajendran

Krishnanswamy

2021

J Pediatr Neurosci

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A BSTRACT Objective: Central nervous system (CNS) tumors are the second most common neoplasms in children and they differ from their adult counterparts in terms of incidence, topography, clinical features, histology, and outcome. This article analyzes the incidence of supratentorial tumors, various histopathological entities, and their characteristics in pediatric patients <18 years of age. Materials and Methods: This was a retrospective study conducted at the Department of Neuropathology, Institute of Neurosurgery, MMC/RGGGH Chennai from January 2017 to December 2019. Data of supratentorial tumors in children less than 18 years of age procured and their histomorphological profile were analyzed. Results: In our institution, of a total of 1134 CNS and spinal neoplasms, 117 pediatric intracranial and 7 spinal neoplasms were reported and the incidence of supratentorial pediatric tumors was 44.44% (52 cases). Among which intraaxial tumors account for 38.46% with 20 cases, extraaxial tumors 51.92% with 27 cases, and intraventricular tumors 9.61% with five reported cases. Most common tumors reported were astrocytomas, craniopharyngioma, followed by ependymoma among others Conclusion: Though posterior fossa neoplasms are more common in children, supratentorial tumors show a rising trend worldwide in the pediatric population. Our study gives an overview of the incidence and histopathological profile of supratentorial CNS tumors.

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MR imaging of glioblastoma in children: usefulness of diffusion/perfusion-weighted MRI and MR spectroscopy

Chang

Yoon

Shin

et al. 2003

Pediatric Radiology

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Supratentorial primary intra-axial tumors in children

Abstract: In most cases, the exact diagnosis should be made by histological examination but it is important for treatment planning that the appropriate depiction of tumor extension and tissue characterization be made by MR and CT.

Cited by 4 publications

References 24 publications

Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images

Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images

Histomorphological spectrum of pediatric supratentorial CNS tumors: A 3-year retrospective study in a tertiary care center

MR imaging of glioblastoma in children: usefulness of diffusion/perfusion-weighted MRI and MR spectroscopy

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