SUR2A: How to exploit this protein to treat ischaemic heart disease?

Jovanović, Aleksandar

doi:10.5937/arhfarm2001001j

Arhiv za farmaciju

2020

DOI: 10.5937/arhfarm2001001j

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SUR2A: How to exploit this protein to treat ischaemic heart disease?

Aleksandar Jovanović¹

Abstract: SUR2A je atipični ABC protein koji služi kao regulatorna podjedinica sarkolemalnih ATPsenzitivnih kalijumovih (KATP) kanala. Kod eksperimentalnih životinja ustanovljeno je da porast nivoa ovog proteina u miokardu štiti srce od različitih vrsta metaboličkih stresova, uključujući ishemiju. Povećanje SUR2A dovodi do porasta broja kompletno formiranih KATP kanala, što je povezano sa ranijom aktivacijom kanala u toku ishemije, kao i povećanjem proizvodnje ATP-a aktivnošću enzima koji su fizički povezani s podjedini… Show more

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Increase in cardioprotective SUR2A does not alter heart rate and heart rate regulation by physical activity and diurnal rhythm

Sudhir

Jaafar

et al. 2021

Journal of Basic and Clinical Physiology and Pharmacology

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SUR2A is an ABC protein serving as a regulatory subunit of ATP-sensitive (KATP) channels. An increase in SUR2A levels is cardioprotective and it is a potential therapeutic strategy against ischaemic heart disease, heart failure and other diseases. However, whether overexpression of this protein has any adverse effects is yet to be fully understood. Objectives Here, we examined the heart rate and the heart rate diurnal variation in mice overexpressing SUR2A (SUR2A+) and their littermate controls (WT) using ECG telemetry that was continuously recorded for 14 days (days 8–23 post-radiotransmitter implantation). Methods Using SigmaPlot 14.0 and Microsoft Excel, Area Under the Curve (AUC) for each parameter was calculated and plotted in a graph. Results Both WT and SUR2A+ mice were more physically active during nights and there were no significant differences between two phenotypes. Physical activity was associated with increased heart rate in both phenotypes, but there were no differences in heart rate between phenotypes irrespective of physical activity or time of the day. A diurnal heart rate variation was preserved in the SUR2A+ mice. As area under the curve (AUC) analysis has the potential to reveal differences that are invisible with other statistical methods, we compared AUC of heart rate in SUR2A+ and WT mice. This analysis did not yield anything different from traditional analysis. Conclusions We conclude that increased SUR2A levels are not associated with changes in physical activity, heart rate and/or circadian rhythm influence on the heart rate. This lack of adverse effects supports a notion that manipulation with SUR2A levels is a promising cardioprotective strategy.

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Increase in cardioprotective SUR2A does not alter heart rate and heart rate regulation by physical activity and diurnal rhythm

Sudhir

Jaafar

et al. 2021

Journal of Basic and Clinical Physiology and Pharmacology

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A brief overview of cardioprotective signaling

Jovanović

2024

Arhiv za farmaciju

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Cardioprotection is defined as the intrinsic ability of cardiac tissue to withstand challenges like ischemia-reperfusion and different metabolic stresses. Initially observed through ischemic preconditioning, the scope of cardioprotection has expanded to include other inducers of cardioprotective signaling like hypoxia, temperature fluctuations, and many pharmacological agents, suggesting the existence of shared signaling pathways and protective cascades. So far, intracellular signaling factors contributing to cardioprotection include protein kinases, the reperfusion injury salvage kinase (RISK) pathway, the Survivor Activating Factor Enhancement (SAFE) pathway, hypoxia-inducible factor-1a (HIF1a), microRNAs, Connexin 43, and many others. These factors play roles in activating downstream signaling elements and protective genes, enhancing mitochondrial function, and regulating protein expression and cytosolic functions to confer cardioprotection. SUR2A, a regulatory subunit of sarcolemmal ATP-sensitive K+ (KATP) channels, autophagy and mitochondria are highlighted as crucial end-effectors, with mechanisms like regulation of the mitochondrial permeability transition pore and activation of KATP channels being pivotal for cardioprotection. Despite advances in understanding these pathways, many aspects of cardioprotection remain to be better understood. It is a particular challenge to further explore therapeutic potentials and, finally, develop clinically viable strategies for cardiac protection.

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SUR2A: How to exploit this protein to treat ischaemic heart disease?

Cited by 2 publications

References 31 publications

Increase in cardioprotective SUR2A does not alter heart rate and heart rate regulation by physical activity and diurnal rhythm

Increase in cardioprotective SUR2A does not alter heart rate and heart rate regulation by physical activity and diurnal rhythm

A brief overview of cardioprotective signaling

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