Surface analysis, hydrophilic enhancement, ageing behavior and flow in plasma modified cyclic olefin copolymer (COC)-based microfluidic devices

Roy, Sunanda; Yue, Chee Yoon; Lam, Yee Cheong; Wang, Z.Y.; Hu, Huifang

doi:10.1016/j.snb.2010.08.043

Cited by 84 publications

(89 citation statements)

References 36 publications

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“…ENCs can undergo plasma, gamma or electron beam treatment in order to be sterilized, but most of the time a surface modification is desired [11,20,96,97,100,[114][115][116][117][118][119][120].…”

Section: Ageing By Ionizing Radiationmentioning

confidence: 99%

“…Roy et al [11,20] used radiofrequency (RF) argon and argon-oxygen plasma to enhance COC (Topas 6015 and 5013) surface properties for applications in microfluidic devices. The goal was to investigate the influence of ageing on the surface properties of plasma-treated COC.…”

Section: Plasma Treatment Of Cocmentioning

confidence: 99%

“…In addition, they are widely used in the field of diagnostics for microwell plates as well as microfluidic devices and biodiagnostic chips [11][12][13][14][15][16][17][18][19][20][21][22]. COC have a low density and low autofluorescence [12,23].…”

Section: Introductionmentioning

confidence: 99%

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Physico-chemical ageing of ethylene–norbornene copolymers: a review

et al. 2017

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The main object of this report is to review and summarize the current state of the scientific literature relating to physico-chemical ageing of ethylene-norbornene copolymers (ENCs). These processes occur through different means such as photodegradation under the effect of ultraviolet radiation, temperature and ionizing radiation (under air or oxygen). In most cases ageing causes chains scissions that lead to the creation of degradation compounds that exhibit high mobility, corresponding to their low molecular weight and/or high polarity. Cross-linking can also occur, leading to the modification of mechanical properties. The presence of oxygen during ageing is of great importance for the physico-chemical modifications of those polymers in terms of oxidation and thermal stability. ENCs belong to cyclic olefin copolymers (COC) class, whose synthesis was developed in the late 1950s. Nevertheless, commercial applications are relatively new. They attract growing interest in different fields, due to their very useful physical and chemical properties such as transparency, heat and chemical resistance, low permeability to gas as well as biocompatibility. In the literature, a large number of papers deal with the synthesis and characterization of different grades of ENC, but only a few deal with the effects of ageing on these materials. This literature review consists of a summary of the main milestones in the development of COC as well as of cyclic olefin polymers (COP), a review of main techniques for predicting ageing, degradation of additives and interaction between COC/COP and contact environment as well as toxicity of the extractables.

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Section: Ageing By Ionizing Radiationmentioning

confidence: 99%

Section: Plasma Treatment Of Cocmentioning

confidence: 99%

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Physico-chemical ageing of ethylene–norbornene copolymers: a review

et al. 2017

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“…4(2), when the polyester film is removed, the ORDYL photoresist film is removed from the areas where channels are patterned on the thermoplastic. This can be due to two reasons: (1) the plasma treatment microscopically roughens the COC surface thereby increasing the bonding area and (2) the high-energy surface groups can form stronger bonds between the COC and the ORDYL photoresist in contact with the COC treated [46][47][48][49][50].…”

Section: Bonding Proceduresmentioning

confidence: 99%

Direct assembly of cyclic olefin copolymer microfluidic devices helped by dry photoresist

Fissi¹,

Vandormael²,

Francis³

2015

Sensors and Actuators A: Physical

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“…Secondly, the surfaces of microchannels have to be rendered hydrophilic using an appropriate treatment. Moreover, the modified surface ought to be stable and its properties should not change with aging (or storage time) which has been observed [27] in the plasma treated COC microchannels. This is important because any change in surface characteristics may cause substantial loss in the reliability and performance of LOC.…”

Section: Introductionmentioning

confidence: 95%