Surface biocompatible modification of polyurethane by entrapment of a macromolecular modifier

Qin, Zhang; Yh, Liu; Chen, Kevin C.; Zhang, Gonggen; Shi, Xuhua; Chen, Hanjia

doi:10.1016/j.colsurfb.2012.07.037

Cited by 30 publications

(19 citation statements)

References 26 publications

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“…Besides covalent strategies functional antifouling additives can be simply mixed with base polymers to create biomaterials with antifouling properties. The antifouling function is introduced either via hydrophilic compounds, such as poly and oligo(ethylene glycols), or via hydrophobic fluorinated groups . Interactions of such additives with the base material are important to ensure both robust incorporation and functionality through sufficient surface exposure of the functional groups.…”

Section: Introductionmentioning

confidence: 99%

“…In studies by Park and Bae, Freij‐Larsson et al, and Lee et al polyurethane (PU) materials were functionalized with macromolecular additives composed of hydrophobic poly(tetrahydrofuran) or poly(propylene glycol) blocks providing easy incorporation, and poly(ethylene glycol) (PEG) functionalities for antifouling properties. The additives in the research by Tan and Brash, Xu et al, and Zhang et al had macromolecular hydrophobic blocks that matched the base materials.…”

Section: Introductionmentioning

confidence: 99%

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Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Ippel

Keizer

Dankers

2018

Adv Funct Materials

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The ultimate functionality of elastomeric materials can be largely influenced by the molecular design of antifouling additives that interact through directed hydrogen bonding bisurea motifs. Herein, three additives, composed of matching bisurea groups and antifouling oligo(ethylene glycol) (OEG) functionalities, are judiciously designed. The first additive is composed of one bisurea and one OEG, the second additive of one bisurea and two OEGs, and the third additive of two bisurea and one OEG. On solution-cast films, non-cell adhesive properties are dependent on the amount of incorporated OEG irrespective of the bisurea design; however, on 3D electrospun scaffolds only the additive that consists of two bisurea moieties connected via an OEG functionality ensures proper non-cell adhesive properties. Interestingly, robust non-cell adhesive properties are maintained, both with repeated cell seeding and after partial enzymatic degradation of the scaffold. These results highlight the importance of additive design in supramolecular functionalization and show that translation from simple 2D solution-cast films to 3D electrospun scaffolds is not trivial with respect to additive presentation and functionality.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Ippel

Keizer

Dankers

2018

Adv Funct Materials

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“…Introduction of interacting motifs promotes mixing of otherwise incompatible polymers. One approach is to introduce polyurethane motifs in polymers to achieve improved intermixing of two polymers 6,7. More delicately designed motifs based on supramolecular chemistry could be employed to improve polymer compatibility.…”

Section: Membrane Properties Of Different Supramolecular Polymer Blendsmentioning

confidence: 99%

Development of Poor Cell Adhesive Immersion Precipitation Membranes Based on Supramolecular Bis‐Urea Polymers

Gaal

Sprang

Borneman

et al. 2019

Macromolecular Bioscience

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A variety of biomedical applications requires tailored membranes; fabrication through a mix‐and‐match approach is simple and desired. Polymers based on supramolecular bis‐urea (BU) moieties are capable of modular integration through directed non‐covalent stacking. Here, it is proposed that non‐cell adhesive properties can be introduced in polycaprolactone‐BU‐based membranes by the addition of poly(ethylene glycol) (PEG)‐BU during immersion precipitation membrane fabrication, while unmodified PEG is not retained in the membrane. PEG‐BU addition results in denser membranes with a similar pore size compared to pristine membranes, while PEG addition induces defect formation. Infrared spectroscopy and surface hydrophobicity measurements indicate that PEG‐BU is retained during membrane processing. Additionally, PEG‐BU incorporation successfully leads to poor cell adhesive surfaces. No evidence is observed to indicate PEG retention. The results obtained indicate that the BU system enables intimate mixing of BU‐modified polymers after processing. Collectively, the results provide the first steps toward BU‐based immersion precipitated supramolecular membranes for biomedical applications.

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“…The host‐philic segment (PP) within the PP‐ b ‐PVP yielded good affinity with the PP base, thus providing more resistance to erosion and extraction by solvents . In a similar manner, the modification of PU was achieved by blending the base polymer with low molecular weight PU‐ b ‐PVP copolymer (1–5%) and forming films by solution‐casting …”

Section: Surface Modifying Additives With Nonfluorinated Oligomeric Cmentioning

confidence: 99%

Surface modifying oligomers used to functionalize polymeric surfaces: Consideration of blood contact applications

López-Donaire

Santerre

2014

J of Applied Polymer Sci

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REVIEWSABSTRACT: The surface modification of existing polymeric biomaterials represents a key strategy for improving the hemocompatibility in long-and short-term biomedical materials without altering their bulk properties. Several techniques have been widely explored to generate surfaces that can prevent the activation of the coagulation system and lead to subsequent clot formation on the surfaces of polymeric blood contacting devices. In particular, strategies whereby the base polymer is blended with surface additives (SMAs) and surface modifying macromolecules (SMMs) are now recognized as practical and effective methods to improve surface polymeric materials. This review highlights the more recent advances in the synthesis of such additives and their blending with base polymers, with a specific focus on SMAs and SMMs with a molecular weight in the oligomeric range (

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Surface biocompatible modification of polyurethane by entrapment of a macromolecular modifier

Cited by 30 publications

References 26 publications

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Development of Poor Cell Adhesive Immersion Precipitation Membranes Based on Supramolecular Bis‐Urea Polymers

Surface modifying oligomers used to functionalize polymeric surfaces: Consideration of blood contact applications

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