Surface‐Bonding‐Enhanced Self‐Co‐Reactant Electrogenerated Chemiluminescence for Sensitive and Selective Detection of Thioglycolic Acid in Cosmetics

Abstract

Thioglycolic acid (TGA) is an organic compound widely used in cosmetics that cause a variety of health problems when overexposed to it. So far many attempts have been made to develop methods for TGA detection, but most of them need sophisticated instrumentations and are a little bit complicated. Therefore, a simple, cheap and sensitive detection method of TGA is highly desired. Herein, we demonstrated for the first time an Au−S bonding amplified, highly sensitive electrochemiluminescence (ECL) sensing method for TGA detection using tris(2,2′‐bipyridyl)ruthenium(II) (Ru(bpy)32+) as a luminophore and TGA as a self‐co‐reactant, via an anodic reaction at the Au electrode surface. Due to different molecular coordination environments of the TGA at the electrode surface, the ECL signal intensity of the developed ECL system gives much higher ECL signal in borate buffer than phosphate buffer of the same pH. Under the optimized experimental conditions, the ECL intensity has a direct relationship with the concentration of TGA in the range of 0.03 μM to 300 μM and a limit of detection of 0.013 μM (3σ/m). The reported ECL system has further been applied for the detection of TGA in cosmetics with acceptable recoveries.

Integration of High-Entropy Oxide with Nitrogen-Doped Graphene for the Ultrasensitive Electrochemiluminescence Detection of Trolox and Dopamine

“…Electrochemiluminescence (ECL), a light-emitting process triggered by the redox reaction of an excited luminophore, − has gotten tremendous attention in potential applications of biological and environmental sensing owing to its merits of simple instrumentation, high sensitivity, and wide dynamic detection range. − In classical luminol ECL systems, luminol is used as an ideal luminophore due to its high emission efficiency, low oxidation potential, and nontoxicity . In practical ECL applications, to enhance the performance of the relevant ECL systems, a coreactant is usually required, and then dissolved O 2 (DO) is often selected due to its excellent stability and ecofriendly characteristics .…”

Boosting Electrochemiluminescence Performance of a Dual-Active Site Iron Single-Atom Catalyst-Based Luminol–Dissolved Oxygen System via Plasmon-Induced Hot Holes

“…Electrochemiluminescence (ECL) is the process of light emission produced when redox species are reacted electrochemically, via a brief exergonic electron-transfer reaction to create excited emitters and eventually release photons. − Due to its easy accessibility, quick reaction, minimal background signals, and great sensitivity, ECL is the most effective tool in the fields of analytical chemistry, medical diagnosis, pharmaceutical analysis, environmental monitoring, and biological analysis. − Among all ECL systems, luminol is the most widely used emitter due to its values of high emitting quantum yield, low cost, and environmental friendliness. , Also, recently, dissolved oxygen (DO) has been considered an effective coreactant (and may be superior to commonly used coreactant H 2 O 2 ) to produce reactive oxygen species (ROS), which can react with luminol anion radicals to produce remarkable ECL signals . Even though DO increases the durability of biological and/or environmental ECL sensors, its low ECL reaction efficiency, low content, and instability significantly hinder its practical applications …”