Surface characteristics and biocompatibility of cranioplasty titanium implants following different surface treatments

Hatamleh, Muhanad M.; Wu, Xiaohong; Alnazzawi, Ahmad; Watson, Jason; Watts, David C.

doi:10.1016/j.dental.2018.01.016

Cited by 63 publications

(43 citation statements)

References 36 publications

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“…To obtain rutile at low temperatures, precipitation of crystalline TiO 2 and hydrothermal methods are needed [21]. The biological effects of the morphological characteristics of the implant surfaces have been thoroughly investigated [17,22], while little information concerns the influence of the different polymorphic crystalline phases of TiO 2 on osseointegration. The crystalline phase of TiO 2 can influence bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Micro-Raman Spectroscopy of Dental Implants Subjected to Different Surface Treatments

et al. 2020

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The aim of the study was to qualitatively investigate the structure of the surface layer of TiO2 on dental implants made of Ti-6Al-4V subjected to different manufacturing treatments. M (machined), B (Al2O3-blasted), E (HNO3\HF-etched), B + E and A (B + E + anodized) implants and a further group receiving the same treatments as the first group with the addition of a final decontamination with cold plasma were included in the study. Examination was performed using micro-Raman spectroscopy. The surface treatments evaluated did not achieve the formation of crystalline TiO2. The increase in the complexity of surface treatment produced a proportional increase in the thickness of amorphous TiO2 oxide. In the B + E group, the plasma treatment enhanced the amorphous oxide thickness of TiO2. The other surfaces treated by plasma decontamination did not show a difference to the respective untreated ones. The investigated surface treatments did not change the crystalline cage of TiO2 in Ti-6Al-4V implants but affected the thickness of the oxide layer. The biological response could be influenced by different oxide thicknesses. Additional information on superficial TiO2 structural organization can be obtained by micro-Raman evaluation of dental implants. Dental implants with B + E + plasma and A superficial treatments allowed the maximum formation of the amorphous oxide thickness.

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Section: Introductionmentioning

confidence: 99%

Micro-Raman Spectroscopy of Dental Implants Subjected to Different Surface Treatments

et al. 2020

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“…Furthermore, the cytocompatibility tests indicated that besides their bioactive behavior, the films were also non-toxic and stimulated the proliferation of osteoblast-like cells. Roughness was long advertised to play an important role on the biological response of implants [91,92]. Since the Bio-HA sputtered films were rather smooth (R rms ≈ 15 nm) and uniform, the in vitro biological response (i.e., bioactivity, cell shape modifications, and their accelerated proliferation rate) could be associated prominently to the chemical and structural nature of the biological HA coatings.…”

Section: Discussionmentioning

confidence: 99%

Animal Origin Bioactive Hydroxyapatite Thin Films Synthesized by RF-Magnetron Sputtering on 3D Printed Cranial Implants

Chioibasu

Duta

Popescu-Pelin

et al. 2019

Metals

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Ti6Al4V cranial prostheses in the form of patterned meshes were 3D printed by selective laser melting in an argon environment; using a CO2 laser source and micron-sized Ti6Al4V powder as the starting material. The size and shape of prostheses were chosen based on actual computer tomography images of patient skull fractures supplied in the framework of a collaboration with a neurosurgery clinic. After optimizations of scanning speed and laser parameters, the printed material was defect-free (as shown by metallographic analyses) and chemically homogeneous, without elemental segregation or depletion. The prostheses were coated by radio-frequency magnetron sputtering (RF-MS) with a bioactive thin layer of hydroxyapatite using a bioceramic powder derived from biogenic resources (Bio-HA). Initially amorphous, the films were converted to fully-crystalline form by applying a post-deposition thermal-treatment at 500 °C/1 h in air. The X-ray diffraction structural investigations indicated the phase purity of the deposited films composed solely of a hexagonal hydroxyapatite-like compound. On the other hand, the Fourier transform infrared spectroscopic investigations revealed that the biological carbonatation of the bone mineral phase was well-replicated in the case of crystallized Bio-HA RF-MS implant coatings. The in vitro acellular assays, performed in both the fully inorganic Kokubo’s simulated body fluid and the biomimetic organic–inorganic McCoy’s 5A cell culture medium up to 21 days, emphasized both the good resistance to degradation and the biomineralization capacity of the films. Further in vitro tests conducted in SaOs-2 osteoblast-like cells showed a positive proliferation rate on the Bio-HA RF-MS coating along with a good adhesion developed on the biomaterial surface by elongated membrane protrusions.

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“…Using this method, however, it is not possible to create a specific, well-defined surface topography. Sulfuric acid is commonly used to modify titanium surfaces for biological applications, and gradually higher concentrations of this acid have induced an increase in surface roughness 65 . Hydrofluoric acid is used for etching ceramic substrates in order to enlarge their binding surface for various reagents, rather than for treating titanium alloys 66 .…”

Section: Acid Etchingmentioning

confidence: 99%

“…The surface is relatively coarse after blasting or sanding (the pits are in the macrometric scale), and it is irregular. However, after acid etching, the surface is more uniform, with small pits with an average diameter of 1-2 μm 65 .…”

Section: Sla Surfacesmentioning

confidence: 99%

Treatments for enhancing the biocompatibility of titanium implants

Štěpanovská¹,

Matějka²,

Rosina³

et al. 2020

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Titanium surface treatment is a crucial process for achieving sufficient osseointegration of an implant into the bone. If the implant does not heal sufficiently, serious complications may occur, e.g. infection, inflammation, aseptic loosening of the implant, or the stress-shielding effect, as a result of which the implant may need to be reoperated. After a titanium graft has been implanted, several interactions are crucial in order to create a strong bone-implant connection. It is essential that cells adhere to the surface of the implant. Surface roughness has a significant influence on cell adhesion, and also on improving and accelerating osseointegration. Other highly important factors are biocompatibility and resistance to bacterial contamination. Bio-inertness of titanium is ensured by the protective film of titanium oxides that forms spontaneously on its surface. This film prevents the penetration of metal compounds, and it is well-adhesive for calcium and phosphate ions, which are necessary for the formation of the mineralized bone structure. Since the presence of the film alone is not sufficient for the biocompatibility of titanium, a suitable surface finish is required to create a firm bone-implant connection. In this review, we explain and compare the most widely-used methods for modulating the surface roughness of titanium implants in order to enhance cell adhesion on the surface of the implant, e.g. plasma spraying, sandblasting, acid etching, laser treatment, sol-gel etc., The methods are divided into three overlapping groups, according to the type of modification. ) is gratefully acknowledged for his language revision of the manuscript. We also thank the Prospon s.r.o. company (Kladno, Czech Republic) for providing Ti6Al4V samples for studies on cell-material interaction.

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Surface characteristics and biocompatibility of cranioplasty titanium implants following different surface treatments

Cited by 63 publications

References 36 publications

Micro-Raman Spectroscopy of Dental Implants Subjected to Different Surface Treatments

Micro-Raman Spectroscopy of Dental Implants Subjected to Different Surface Treatments

Animal Origin Bioactive Hydroxyapatite Thin Films Synthesized by RF-Magnetron Sputtering on 3D Printed Cranial Implants

Treatments for enhancing the biocompatibility of titanium implants

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