Friction-wear properties of a Co-29 mass%Cr-6 mass%Mo alloy (ASTM F799-95) but reducing the amount of nickel were evaluated with friction-wear test using a pin-on-flat type reciprocating friction tester in air and phosphate buffered saline, PBS(À), as a quasi-biological environment under applied stress of 1.0, 3.5 and 5.0 MPa to understand the performance of this alloy for metal-on-metal type artificial hip joints. In addition, metal ions dissolved in PBS(À) after the test was quantified. As a result, wear loss in PBS(À) is much smaller than that in air and increases with the increase of applied stress in both air and PBS(À), while the coefficient of friction in steady state during the test is larger in PBS(À) than in air, according to lubrication behavior of wear debris and PBS(À). Wear damage in PBS(À) is smaller than that in air, however more small scale of irregularity is observed in PBS(À) than that in air. Nickel and molybdenum are preferentially dissolved during the test.