Surface characterization of titanium implants

Raikar, Ganesh N.; Gregory, J. C.; Ong, Joo L.; Lucas, L. C.; Lemons, JE; Kawahara, Dai; Nakamura, Morihiko

doi:10.1116/1.579462

Cited by 55 publications

(24 citation statements)

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“…3,4 Depending on the sterilization technique and surface treatments, oxide thickness in the range of 30 to 100 Å were often reported. 5,6 Because rapid adsorption of proteins have been shown to be the first few events occurring when a foreign material is implanted, the investigation of protein adsorption on implant surfaces needs to be critically evaluated. [7][8][9][10] Protein adsorption, such as the adsorption of human serum protein on TiO 2 , had been attributed to a salt bridge.…”

Section: Introductionmentioning

confidence: 99%

Protein adsorption on titanium surfaces and their effect on osteoblast attachment

Yang

Cavin

Ong

2003

J Biomedical Materials Res

148

107

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The objective of this study was to investigate the adsorption of albumin and fibronectin on titanium (Ti) surfaces and the effect of preadsorbed albumin and fibronectin on osteoblast attachment in vitro. Bovine serum albumin and bovine fibronectin were used in this study. Maximum adsorption of bovine serum albumin and fibronectin on Ti surfaces was observed to occur after 180-min incubation. In the presence of preadsorbed proteins, osteoblast attachment on Ti surfaces was observed to be enhanced compared to control Ti surfaces. However, cell attachment was affected by the types of protein adsorbed. Preadsorbed albumin was observed to have no significant effect on the amount of osteoblast cells attached. In comparison to control Ti surface and Ti surfaces preadsorbed with albumin, Ti surfaces preadsorbed with fibronectin for 15 min was observed to significantly increase osteoblast cell attachment, whereas Ti surfaces preadsorbed with fibronectin for 180 min did not affect cell attachment. In addition, cell morphology of the attached cells on protein preadsorbed Ti surfaces was not affected by the type of protein used in this study. It was concluded from this study that the concentration of fibronectin adsorbed on Ti surfaces was higher compared to albumin. In addition, it was also concluded that the concentration of fibronectin on Ti surfaces plays a role in governing cell attachment.

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Section: Introductionmentioning

confidence: 99%

Protein adsorption on titanium surfaces and their effect on osteoblast attachment

Yang

Cavin

Ong

2003

J Biomedical Materials Res

148

107

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“…An intense peak at 531.3 eV is assigned to the combined contribution of OH − , PO4 3− and CO3 2− groups, which are inseparable by peak-fitting routine due to their similar binding energies [60,61]. The minor peak at 532.7 eV is attributed to the adsorbed water or C-and O-containing contaminations [61,62]. The Ca 2p3/2, P 2p and O 1s located at, respectively, 347.3, 133.8 and 531.3 eV are consistent with the typical binding energies of hydroxyapatite.…”

Section: Xps and Ft-ir Analysismentioning

confidence: 99%

Nanocrystalline β-Ta Coating Enhances the Longevity and Bioactivity of Medical Titanium Alloys

Liu

Jiang

2016

Metals

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A β-Ta nanocrystalline coating was engineered onto a Ti-6Al-4V substrate using a double cathode glow discharge technique to improve the corrosion resistance and bioactivity of this biomedical alloy. The new coating has a thickness of~40 µm and exhibits a compact and homogeneous structure composed of equiaxed β-Ta grains with an average grain size of~22 nm, which is well adhered on the substrate. Nanoindentation and scratch tests indicated that the β-Ta coating exhibited high hardness combined with good resistance to contact damage. The electrochemical behavior of the new coating was systematically investigated in Hank's physiological solution at 37 • C. The results showed that the β-Ta coating exhibited a superior corrosion resistance as compared to uncoated Ti-6Al-4V and commercially pure tantalum, which was attributed to a stable passive film formed on the β-Ta coating. The in vitro bioactivity was studied by evaluating the apatite-forming capability of the coating after seven days of immersion in Hank's physiological solution. The β-Ta coating showed a higher apatite-forming ability than both uncoated Ti-6Al-4V and commercially pure Ta, suggesting that the β-Ta coating has the potential to enhance functionality and increase longevity of orthopaedic implants.

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“…Commercially pure titanium (cpTi) and Ti-6Al-4V alloys are the most commonly used metallic implant materials, as they are highly biocompatible materials with excellent mechanical properties and corrosion resistance (1)(2)(3)(4). The biocompatibility of titanium implants is attributed to the stable oxide layer (with a thickness of 3-10 nm) that spontaneously forms when titanium is exposed to oxygen (5,6). This reaction prevents the formation of fibrous tissue around the implant, and creates direct contact to osseous tissue.…”

Section: Introductionmentioning

confidence: 99%

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

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Abstract. This paper reviews current physicochemical and biochemical coating techniques that are investigated to enhance bone regeneration at the interface of titanium implant materials. By applying coatings onto titanium surfaces that mimic the organic and inorganic components of living bone tissue, a physiological transition between the non-physiological titanium surface and surrounding bone tissue can be established. In this way, the coated titanium implants stimulate bone formation from the implant surface, thereby enhancing early and strong fixation of bone-substituting implants. As such, a continuous transition from bone tissue to implant surface is induced. This review presents an overview of various techniques that can be used to this end, and that are inspired by either inorganic (calcium phosphate) or organic (extracellular matrix components, growth factors, enzymes, etc.) components of natural bone tissue. The combination, however, of both organic and inorganic constituents is expected to result into truly bone-resembling coatings, and as such to a new generation of surface-modified titanium implants with improved functionality and biological efficacy.

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Surface characterization of titanium implants

Cited by 55 publications

References 0 publications

Protein adsorption on titanium surfaces and their effect on osteoblast attachment

Protein adsorption on titanium surfaces and their effect on osteoblast attachment

Nanocrystalline β-Ta Coating Enhances the Longevity and Bioactivity of Medical Titanium Alloys

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

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