Surface Engineering of Carbon Nanodots (C-Dots) for Biomedical Applications

Yi, Changqing; Pan, Yi; Fang, Yaning

doi:10.1016/b978-0-12-814497-8.00005-9

Cited by 10 publications

(8 citation statements)

References 184 publications

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“…It has been widely reported that heavy metal ions can strongly coordinate with the surface functional groups of CDs and thus changing their emission properties. ,− Therefore, three kinds of CDs with different optical features and surface functionalities have been synthesized and conditioned for sensing different heavy metal ions, namely, CDs-1 for Hg 2+ detection, CDs-2 for Pb 2+ detection, and CDs-3 for Cu 2+ detection. − TEM images revealed that all the as-prepared CDs were monodispersed and exhibited narrow size distribution (Figure a-c). The average diameters of CDs-1, CDs-2, and CDs-3 were 4.0 ± 2.0, 2.0 ± 1.0, and 5.0 ± 2.0 nm, respectively (insets of Figure a–c).…”

Section: Resultsmentioning

confidence: 99%

“…Due to their unique emission properties and nontoxic features, fluorescent carbon nanodots (CDs), which consist of graphite core and carbonaceous surface, promote the development of bioimaging probes, high-performance chemo/biosensors, and multifunctional nanocomposites for theranostics. − More importantly, chemical groups on CDs surface can be easily tuned to exhibit the varying binding properties toward various metal ions through tailoring the synthesis precursors. − Their unique emission properties and versatile surface functional groups render CDs sensing capabilities for a wide range of metal ions with high sensitivity and selectivity, including Ag + , K + , Pb 2+ , Cu 2+ , Hg 2+ , Zn 2+ , Fe 3+ , Au 3+ , and Cr 6+ . For example, CDs surface can be tuned to contain phenolic hydroxyl groups, which exhibit strong coordination toward Fe 3+ , and their emission can be selectively quenched by Fe 3+ via a PET mechanism. , …”

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confidence: 99%

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A Smartphone-Based Sensing System for On-Site Quantitation of Multiple Heavy Metal Ions Using Fluorescent Carbon Nanodots-Based Microarrays

et al. 2020

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The development of cost-effective and versatile sensing system for simultaneous and rapid quantitation of multiple targets is highly demanded for environmental surveillance, food safety inspection, home healthcare, etc. This work reports on (1) paper-based microarrays relying on fluorescence turn-off of carbon nanodots (CDs) for analyte recognition and (2) a stand-alone smartphone-based portable reader (SBR) installed with a customdesigned APP (SBR-App), which can accurately and reproducibly acquire fluorescence change from the microarray chip, automatically report the results, generate and share the reports via wireless network. Simultaneous detection of Hg 2+ , Pb 2+ , and Cu 2+ in the Pearl River water samples was achieved with the reported sensing system. End-user operation is limited to pipet samples to the microarray chip, insert the chip to the SBR, and open the SBR-App to acquire an image 5 min after sample introduction. There is no requirement for complicated sample pre-treatment and expensive equipment except for a smartphone. This versatile and costeffective smartphone-based sensing system featured with reliability and simplicity is ideally suited for user-and eco-friendly point-ofneed detection in resource-constrained environments.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

A Smartphone-Based Sensing System for On-Site Quantitation of Multiple Heavy Metal Ions Using Fluorescent Carbon Nanodots-Based Microarrays

et al. 2020

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“…The surface state of the C-Dots such as chemical compositions and surface functional groups are closely related to the multicolour emissions from C-Dots (Barman and Patra, 2018) (Yi et al, 2019). Surface defects can act as trapping centers for excitons and abundant groups such as amino and carboxyl groups on the C-Dots surface tend to form a conjugated π-domain structure, causing surface state-related emissions which resulted from the higher degree of oxidation and surface function .…”

Section: Surface-related Defective Sitesmentioning

confidence: 99%

“…Tailoring the structural defects, surface functional groups and interactions among carbon atoms with their neighboring atoms may introduce new surface properties of the C-Dots that is closely related to heteroatom doping with other elements. Additionally, there are two types of doping in terms of the number of dopants, namely single doping and multi-doping (Favaro et al, 2015;Yi et al, 2019).…”

Section: Heteroatom Dopingmentioning

confidence: 99%

A Review on Multifunctional Carbon-Dots Synthesized From Biomass Waste: Design/ Fabrication, Characterization and Applications

et al. 2021

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Carbon-Dots (C-Dots) have drawn much attention in recent years owing to their remarkable properties such as high biocompatibility, low toxicity, nano-scale size, and ease of modification with good tuneable photoluminescence performance. These unique properties have led C-Dots to become a promising platform for bioimaging, metal ion sensing and an antibacterial agent. C-Dots can be prepared using the top-down and bottom-up approaches, in which the latter method is commonly used for large scale and low-cost synthesis. C-Dots can be synthesized using sustainable raw materials or green biomass since it is environmentally friendly, in-expensive and most importantly, promotes the minimization of waste production. However, using biomass waste to produce high-quality C-Dots is still a matter of concern waiting for resolution, and this will be the main focus of this review. Fundamental understanding of C-Dots such as structure analysis, physical and chemical properties of C-Dots, various synthesis methodology and type of raw materials used are also discussed and correlated comprehensively. Additionally, factors affecting the bandgap of the C-Dots and the strategies to overcome these shortcomings are also covered. Moreover, formation mechanism of C-Dots focusing on the hydrothermal method, option and challenges to scale up the C-Dots production are explored. It is expected that the great potential of producing C-Dots from agricultural waste a key benefit in view of their versatility in a wide range of applications.

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“…Doping also can improve the quantum yield of the QDs. Various dopants such as N, S, and P have been widely employed for evaluating QDs characteristic features towards applications (Yi et al, 2019).…”

Section: Drop-casting Approachmentioning

confidence: 99%

Quantum Dots: An Emerging Approach for Cancer Therapy

Devi¹,

Kumar

Tiwari

et al. 2022

Front. Mater.

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Nanotechnology is indisputably a scientific technique that offers the prospect of new therapies, and hope, for the treatment of malignant illnesses. It is a novel technology that offers new approaches for the diagnosis and management of diverse diseases. Although the discovery of Quantum dots (QD) nano-transporters has already led to a few positive developments, QD nano-transporters are still at their initial stage, though have yet proven valuable to society. The excertion of QD indicates conversion in natural imaging along with photograph have established incredible suitability in bio-imaging, new drug development, targeted gene deliverance, biosensing, photodynamic treatment as well as diagnosis. The present review aimed to confer the significance of QD in diagnosis as well as in management of cancer. This review aims to impart fundamental insight as well as conception of QD its merits, properties, utilization as well as mode of action. This review highlight of different designing schemes of QD like hydrothermal, drop-casting, ultrasonic, solvothermal, spin-coating, atomic layer desorption, layer by layer, polymethylmethacrylate aided-transfer, electrochemical, ion beam sputtering deposition. Moreover, we have elaborated on the diverse researches related to cytotoxic examination to reveal that QDs are harmless. Concisely, the present review summarizes the fabrication schemes, current research and utilization of QD in cancer treatment.

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Surface Engineering of Carbon Nanodots (C-Dots) for Biomedical Applications

Cited by 10 publications

References 184 publications

A Smartphone-Based Sensing System for On-Site Quantitation of Multiple Heavy Metal Ions Using Fluorescent Carbon Nanodots-Based Microarrays

A Smartphone-Based Sensing System for On-Site Quantitation of Multiple Heavy Metal Ions Using Fluorescent Carbon Nanodots-Based Microarrays

A Review on Multifunctional Carbon-Dots Synthesized From Biomass Waste: Design/ Fabrication, Characterization and Applications

Quantum Dots: An Emerging Approach for Cancer Therapy

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