Surface engineering of titanium alloy using metal-polyphenol network coating with magnesium ions for improved osseointegration

Lee, Sang‐Min; Chang, Yoon-Kyung; Lee, Jin-Kyu; Perikamana, Sajeesh Kumar Madhurakkat; Kim, Eun Mi; Jung, Yang-Hun; Yun, Jeong‐Ho; Shin, Heungsoo

doi:10.1039/d0bm00566e

Cited by 61 publications

(51 citation statements)

References 48 publications

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“…Previously, our group reported the EGCG coating on Ti surface in the presence of Mg 2 + , and investigated their effect on osteogenic differentiation of human adipose-derived stem cells (hAD-SCs) and suppression of osteoclast functions [25] . Compared to this previous work, the current study is focused on the evaluation of the anti-oxidative properties of EGCG-coated biomaterial surfaces and their effects on cells, based on the structural and chemical properties of EGCG through 2D and 3D culture conditions for hADSCs.…”

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confidence: 99%

Evaluation of the anti-oxidative and ROS scavenging properties of biomaterials coated with epigallocatechin gallate for tissue engineering

Lee

Byun

et al. 2021

Acta Biomaterialia

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In tissue engineering, excessively generated reactive oxygen species (ROS) during biomaterial implantation or cell transplantation is a one of major causes of diminishing therapeutic effects. In this study, we prepared biomaterial surfaces coated with antioxidant epigallocatechin gallate (EGCG) and metal ions, and evaluated their anti-oxidative and ROS scavenging properties. We revealed that EGCG-coating on polycaprolactone (PCL) film surface increased hydrophilicity and anti-oxidative properties as a function of total phenol content (TPC) potentially due to the increase in phenolic -OH and π -electrons from structural maintenance and directly removed the hydrogen peroxide (H 2 O 2 ) by resonance-stabilization. Furthermore, EGCG-coated PCL film increased attachment, spreading area, and viability of human adipose-derived stem cells (hADSCs) against H 2 O 2 treatment while stimulated the cellular signaling to reduce apoptotic gene and enhance anti-oxidative enzyme expression. Further, we applied EGCG coating on the surface of poly-L-lactic acid (PLLA) fibers. Spheroids incorporating EGCG-coated PLLA fibers were able to maintain their shape and showed improved viability and anti-oxidative activities in response to H 2 O 2 -induced oxidative stress than control spheroids. Therefore, metal-phenolic network (MPN) coating of EGCG is a suitable method to impart the anti-oxidative properties to biomaterials by evaluating the structural properties and biological effects. Statement of SignificanceThis manuscript describes an antioxidant coating for biomaterials to control reactive oxygen species (ROS). Antioxidant epigallocatechin gallate (EGCG) was coated on the PCL film surface via metal-phenolic network (MPN). We revealed that the phenolic functional groups of EGCG are structurally maintained as confirmed by quantitative reducing power, radical scavenging assays. EGCG coating not only removed ROS directly, but also is involved in cell signaling to enhance the anti-apoptotic gene, anti-oxidative enzyme expression. Furthermore, human adipose-derived stem cells (hADSCs) spheroid produced by self-assembly with EGCG-coated poly-L-lactic aicd (PLLA) fibers showed anti-oxidative properties from inside of spheroids. Thus, our evaluation of the anti-oxidative properties of EGCG coating can be applied to various tissue engineering applications.

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confidence: 99%

Evaluation of the anti-oxidative and ROS scavenging properties of biomaterials coated with epigallocatechin gallate for tissue engineering

Lee

Byun

et al. 2021

Acta Biomaterialia

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“…Other polyphenolic molecules of interest derived from natural sources include catechins and pyrogallol [ 88 ]. Polyphenol functionalization of titanium dental implants can give antibacterial effects as well as enhanced osteointegration and osteoinduction [ 89 , 90 ].…”

Section: Structural Enhancements and Experimental Designsmentioning

confidence: 99%

Microbial Decontamination and Antibacterial Activity of Nanostructured Titanium Dental Implants: A Narrative Review

et al. 2021

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Peri-implantitis is the major cause of the failure of dental implants. Since dental implants have become one of the main therapies for teeth loss, the number of patients with peri-implant diseases has been rising. Like the periodontal diseases that affect the supporting tissues of the teeth, peri-implant diseases are also associated with the formation of dental plaque biofilm, and resulting inflammation and destruction of the gingival tissues and bone. Treatments for peri-implantitis are focused on reducing the bacterial load in the pocket around the implant, and in decontaminating surfaces once bacteria have been detached. Recently, nanoengineered titanium dental implants have been introduced to improve osteointegration and provide an osteoconductive surface; however, the increased surface roughness raises issues of biofilm formation and more challenging decontamination of the implant surface. This paper reviews treatment modalities that are carried out to eliminate bacterial biofilms and slow their regrowth in terms of their advantages and disadvantages when used on titanium dental implant surfaces with nanoscale features. Such decontamination methods include physical debridement, chemo-mechanical treatments, laser ablation and photodynamic therapy, and electrochemical processes. There is a consensus that the efficient removal of the biofilm supplemented by chemical debridement and full access to the pocket is essential for treating peri-implantitis in clinical settings. Moreover, there is the potential to create ideal nano-modified titanium implants which exert antimicrobial actions and inhibit biofilm formation. Methods to achieve this include structural and surface changes via chemical and physical processes that alter the surface morphology and confer antibacterial properties. These have shown promise in preclinical investigations.

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“…The mechanism regarding microwave-MgP interactions is still to be investigated. Lee et al developed a titanium alloy coated with epigallocatechin gallate and MgCI 2 consisting of a metal-polyphenol network (MPN) coating, which could improve delivery of osteoinductive Mg 2+ with the synergistically improved osseointegration at the bone-implant interface ( Figure 5) [93].…”

Section: Magnesiummentioning

confidence: 99%

Surface Modified Techniques and Emerging Functional Coating of Dental Implants

et al. 2020

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Dental implants are widely used in the field of oral restoration, but there are still problems leading to implant failures in clinical application, such as failed osseointegration, marginal bone resorption, and peri-implantitis, which restrict the success rate of dental implants and patient satisfaction. Poor osseointegration and bacterial infection are the most essential reasons resulting in implant failure. To improve the clinical outcomes of implants, many scholars devoted to modifying the surface of implants, especially to preparing different physical and chemical modifications to improve the osseointegration between alveolar bone and implant surface. Besides, the bioactive-coatings to promote the adhesion and colonization of ossteointegration-related proteins and cells also aim to improve the osseointegration. Meanwhile, improving the anti-bacterial performance of the implant surface can obstruct the adhesion and activity of bacteria, avoiding the occurrence of inflammation related to implants. Therefore, this review comprehensively investigates and summarizes the modifying or coating methods of implant surfaces, and analyzes the ossteointegration ability and anti-bacterial characteristics of emerging functional coatings in published references.

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Surface engineering of titanium alloy using metal-polyphenol network coating with magnesium ions for improved osseointegration

Abstract: Although titanium-based implants are widely used in orthopedic and dental clinics, improved osseointegration at the bone–implant interface is still required.

Cited by 61 publications

References 48 publications

Evaluation of the anti-oxidative and ROS scavenging properties of biomaterials coated with epigallocatechin gallate for tissue engineering

Evaluation of the anti-oxidative and ROS scavenging properties of biomaterials coated with epigallocatechin gallate for tissue engineering

Microbial Decontamination and Antibacterial Activity of Nanostructured Titanium Dental Implants: A Narrative Review

Surface Modified Techniques and Emerging Functional Coating of Dental Implants

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