Surface-enhanced Raman scattering in cancer detection and imaging

Vendrell, Marc; Maiti, Kaustabh Kumar; Dhaliwal, Kevin; Chang, Young‐Tae

doi:10.1016/j.tibtech.2013.01.013

Cited by 352 publications

(223 citation statements)

References 78 publications

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“…In recent years, there has been increased interest in blood serum analysis using Surface Enhanced Raman Spectroscopy (SERS), which can compensate for the low Raman scattering efficiency, especially limiting in the case of liquid samples [76]. Reported studies applied to blood serum [77] for the detection of gastric [78,79], colorectal [80], pancreatic [81] and naso-pharyngeal cancers [82] highlight the interest and potential of such approaches.…”

Section: Discussionmentioning

confidence: 99%

Improved protocols for vibrational spectroscopic analysis of body fluids

Bonnier¹,

Petitjean

Baker

et al. 2013

Journal of Biophotonics

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The applications of vibrational spectroscopy to the examination of human blood serum are explored. Although FTIR spectra can be recorded in aqueous solutions at (gelatin) concentrations as low as 100 mg/L, the high-wavenumber region remains obscured by water absorption. Using Raman spectroscopy, high quality spectra of gelatine solutions as low as 10 mg/L can be achieved, also covering the high-wavenumber regions. In human serum, spectral profiles are weak and partially obscured by water features. Dried deposits are shown to be physically and chemically inhomogeneous resulting in reduced measurement reproducibility. Concentration of the serum using commercially available centrifugal filter devices results in an improvement in the spectral intensity and quality. Additionally, in Raman spectroscopy, reduced background and significantly enhanced signal collection is achievable by measurement in an inverted geometry. The improved protocols for spectroscopic measurement of human serum are applicable to a range of bodily fluids and should accelerate potential clinical applications

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Section: Discussionmentioning

confidence: 99%

Improved protocols for vibrational spectroscopic analysis of body fluids

Bonnier¹,

Petitjean

Baker

et al. 2013

Journal of Biophotonics

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“…[4] SERS has been extensively used for molecular/ion detection and bioimaging applications since it minimizes photoblinking or photobleaching from conventional fluorophores, decreases signal-to-noise ratio in vitro and in vivo, as usually Raman reporters are stable and with large quantum yields. [5][6][7][8] Colloidal metal nanoparticles (especially silver and gold) act as good SERS enhancers, via surface electromagnetic field enhancement and chemical contribution. [9] Gold nanoparticles (AuNPs) covered by Raman reporters have been used for SERS to detect cancer cells in vitro and tumours in vivo.…”

Section: Introductionmentioning

confidence: 99%

Antibody–drug gold nanoantennas with Raman spectroscopic fingerprints for in vivo tumour theranostics

Conde

Bao

Cui

et al. 2014

Journal of Controlled Release

101

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“…Since its discovery in the late seventies SERS, which relies on a roughened noble metal substrate to enhance the sensitivity of Raman detection, has become a powerful tool in the early identification and diagnosis of disease [262][263][264][265][266][267][268][269][270][271][272]. The highly localized EM field of the metal, due to SPR, is known to enhance the Raman signal by 5-10 orders of magnitude [273][274][275][276].…”

Section: Surface Enhanced Raman Scattering (Sers) and Electromagneticmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Surface-enhanced Raman scattering in cancer detection and imaging

Cited by 352 publications

References 78 publications

Improved protocols for vibrational spectroscopic analysis of body fluids

Improved protocols for vibrational spectroscopic analysis of body fluids

Antibody–drug gold nanoantennas with Raman spectroscopic fingerprints for in vivo tumour theranostics

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

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