Surface-enhanced Raman scattering on colloidal nanostructures

Aroca, Ricardo F.; Alvarez-Puebla, Ramón A.; Pieczonka, Nicholas P. W.; Sanchez-Cortez, S.; Garcı́a-Ramos, José Vicente

doi:10.1016/j.cis.2005.04.007

Cited by 273 publications

(213 citation statements)

References 135 publications

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“…It is well known that SERS actually is a nanostructureenhanced Raman scattering phenomenon [50]. Therefore, SERS signals (EFs) produced on the nanostructure are strongly related to the size, shape, aggregation state and the type of nanostructures.…”

Section: Nanostructures For Single-molecule Surface-enhanced Raman Spmentioning

confidence: 99%

Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology

Wang

Irudayaraj

2013

Phil. Trans. R. Soc. B

106

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Single-molecule (SM) spectroscopy has been an exciting area of research offering significant promise and hope in the field of sensor development to detect targets at ultra-low levels down to SM resolution. To the experts and developers in the field of surface-enhanced Raman spectroscopy (SERS), this has often been a challenge and a significant opportunity for exploration. Needless to say, the opportunities and excitement of this multidisciplinary area impacts span the fields of physics, chemistry and engineering, along with a significant thrust in applications constituting areas in medicine, biology, environment and agriculture among others. In this review, we will attempt to provide a quick snapshot of the basics of SM-SERS, nanostructures and devices that can enable SM Raman measurement. We will conclude with a discussion on SERS implications in biomedical sciences.

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Section: Nanostructures For Single-molecule Surface-enhanced Raman Spmentioning

confidence: 99%

Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology

Wang

Irudayaraj

2013

Phil. Trans. R. Soc. B

106

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“…Two of the most important and widely studied of these applications involve the emission of light at a different wavelength than the excitation, i.e., secondary light emission: (i) sensing of molecular layers by surface-enhanced Raman scattering (SERS) (2,3); and (ii) imaging of biological microstructures using light emission generated by ultrafast laser pulses, a process often referred to as two-photon luminescence (TPL) (4,5).…”

mentioning

confidence: 99%

Resonant secondary light emission from plasmonic Au nanostructures at high electron temperatures created by pulsed-laser excitation

Huang¹,

Wang

Murphy³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

139

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Plasmonic nanostructures are of great current interest as chemical sensors, in vivo imaging agents, and for photothermal therapeutics. We study continuous-wave (cw) and pulsed-laser excitation of aqueous suspensions of Au nanorods as a model system for secondary light emission from plasmonic nanostructures. Resonant secondary emission contributes significantly to the background commonly observed in surface-enhanced Raman scattering and to the light emission generated by pulsed-laser excitation of metallic nanostructures that is often attributed to two-photon luminescence. Spectra collected using cw laser excitation at 488 nm show an enhancement of the broad spectrum of emission at the electromagnetic plasmon resonance of the nanorods. The intensity of anti-Stokes emission collected using cw laser excitation at 785 nm is described by a 300 K thermal distribution of excitations. Excitation by subpicosecond laser pulses at 785 nm broadens and increases the intensity of the anti-Stokes emission in a manner that is consistent with electronic Raman scattering by a high-temperature distribution of electronic excitations predicted by a two-temperature model. Broadening of the pulse duration using an etalon reduces the intensity of anti-Stokes emission in quantitative agreement with the model. Experiments using a pair of subpicosecond optical pulses separated by a variable delay show that the timescale of resonant secondary emission is comparable to the timescale for equilibration of electrons and phonons.gold nanorods | electron-hole pairs | surface-enhanced Raman scattering background

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“…The spectral features of the Raman scattering are much narrower than fluorescence spectra, and contain a wealth of information about the chemical composition of the sample, which makes it a widely used technique in analytical chemistry. Surface-enhanced Raman scattering (SERS), is a special case where the interactions of a Raman-active compound with a metal surface results in orders-of-magnitude enhancements in scattering intensities (2,3), giving this approach the potential for applications requiring sensitive detection.…”

mentioning

confidence: 99%

A flow cytometer for the measurement of Raman spectra

et al. 2008

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Multiparameter measurements in flow cytometry are limited by the broad emission spectra of fluorescent labels. By contrast, Raman spectra are notable for their narrow spectral features. To increase the multiparameter analysis capabilities of flow cytometry, we investigated the possibility of measuring Raman signals in a flow cytometry-based system. We constructed a Raman Spectral Flow Cytometer, substituting a spectrograph and CCD detector for the traditional mirrors, optical filters, and photomultiplier tubes. Excitation at 633 nm was provided by a HeNe laser, and forward-angle light scatter is used to trigger acquisition of complete spectra from individual particles. Microspheres were labeled with nanoparticle surface enhanced Raman scattering (SERS) tags and measured using the RSFC. Fluorescence and Raman spectra from labeled microspheres were acquired using the Raman Spectral Flow Cytometer. SERS spectral intensities were dependent on integration time, laser power, and detector pixel binning. Spectra from particles labeled with one each of four different SERS tags could be distinguished by either a virtual bandpass approach using commercial flow cytometry data analysis software or by principal component analysis. Raman flow cytometry opens up new possibilities for highly multiparameter and multiplexed measurements of cells and other particles using a simple optical design and a single detector and light source. ' 2008International Society for Analytical Cytology

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Surface-enhanced Raman scattering on colloidal nanostructures

Cited by 273 publications

References 135 publications

Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology

Surface-enhanced Raman spectroscopy at single-molecule scale and its implications in biology

Resonant secondary light emission from plasmonic Au nanostructures at high electron temperatures created by pulsed-laser excitation

A flow cytometer for the measurement of Raman spectra

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