2006
DOI: 10.1002/jrs.1506
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Surface enhanced Raman spectra of oligonucleotides induced by spermine

Abstract: The label-free detection of oligonucleotides of 12-14 bases at a concentration of 10 −7 M (double helix) was achieved by using surface enhanced Raman scattering (SERS) and spermine as the aggregant of Ag sol. The wavenumbers of the produced SERS spectra of DNA are similar to those in the corresponding normal Raman spectra of free DNA, allowing the detailed assignment of the vibrational modes. The conformation of the adsorbed DNA, the adsorption geometry, and a molecular model of the interactions among DNA, spe… Show more

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Cited by 44 publications
(88 citation statements)
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“…It is supposed that this vibration is an overlap between the dC ring breathing mode and the backbone mode in this interval. [25] A shift of this marker band toward higher wavenumbers is to be observed in our present SERS spectra as compared with normal Raman spectrum of DNA and with the SERS data previously obtained by us on plant DNA. [11] Ag nanoparticles have been found to strongly interact with cytosine, due to the available lone pair from exocyclic nitrogen, characterizing dC residue.…”
Section: Resultsmentioning
confidence: 54%
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“…It is supposed that this vibration is an overlap between the dC ring breathing mode and the backbone mode in this interval. [25] A shift of this marker band toward higher wavenumbers is to be observed in our present SERS spectra as compared with normal Raman spectrum of DNA and with the SERS data previously obtained by us on plant DNA. [11] Ag nanoparticles have been found to strongly interact with cytosine, due to the available lone pair from exocyclic nitrogen, characterizing dC residue.…”
Section: Resultsmentioning
confidence: 54%
“…[3,9] Other authors, indicate also the guanine residues as contributors to this vibration. [2,17,25] This band shifted to 1333 cm −1 for DNA isolated from Exacum species and to 1328 cm −1 for DNA extracted from Malus.…”
Section: Resultsmentioning
confidence: 99%
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“…[41][42][43][44][45][46] When adsorbed on the metal surface fluorescence of the drug molecules is quenched, at the same time Raman scattering being enhanced by several orders of magnitude. A large amount of a biological sample usually required for conventional Raman measurements (10 -2 M) is avoided preserving information on structural features of species at concentrations as low as 10 -8 M. During adsorption of the drug/DNA complex on the surface of the silver nanoparticles neither perturbations of the molecular interactions nor changes in the structure of complexes have been obtained.…”
mentioning
confidence: 99%