Surface enhanced Raman spectroscopic studies on aspirin : An experimental and theoretical approach

Premkumar, R.; Premkumar, S.; Rekha, T. N.; Parameswari, A.; Mathavan, T.; Benial, A. Milton Franklin

doi:10.1063/1.4946664

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…Aspirin selectively diffuses into Ag NCs in the microgel, while BSA is excluded, as illustrated in Figure a. Therefore, Raman intensity for aspirin acquired from the mixture is comparable with that from the PBS solution of aspirin only, as shown in Figure b; aspirin has characteristic peaks at 810, 1034, 1145, 1248, 1309, 1379, and 1618 cm −1 , whose assignments are shown in a literature . Aspirin provides pain relief and prevents blood clots when the level is under 10 mg dL −1 in blood .…”

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confidence: 63%

“…The microgels dispersed in whole blood spiked with 30 mg dL −1 aspirin show additional peaks which are not observed in aspirin‐free whole blood, as shown in Figure f. The peaks denoted by black stars at 810 and 1248 cm −1 correspond to characteristic peaks of aspirin . The other peaks denoted by red stars at 719, 923, 1345, and 1438 cm −1 are attributed to the formation of complexes between aspirin and small plasma proteins …”

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confidence: 91%

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Uniform Microgels Containing Agglomerates of Silver Nanocubes for Molecular Size‐Selectivity and High SERS Activity

Kim

Jeon

Park

et al. 2017

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Surface-enhanced Raman scattering (SERS) is a promising technique for molecular analysis as the molecular fingerprints (Raman spectra) are amplified to detectable levels compared with common spectroscopy. Metal nanostructures localize electromagnetic field on their surfaces, which can lead to dramatic increase of Raman intensity of molecules adsorbed. However, the metal surfaces are prone to contamination, thereby requiring pretreatment of samples to remove adhesive molecules. To avoid the pretreatment and potentially achieve point-of-care (POC) analysis, we have developed SERS-active microgels using the droplet-microfluidic system. As the microgels are composed of water-swollen network with consistent mesh size, they selectively allow diffusion of molecules smaller than the mesh, thereby excluding large adhesives. To render the microgels highly SERS-active, we destabilize silver nanocubes to form agglomerates, which are embedded in the matrix of microgels. The nanogaps in the agglomerates provide high sensitivity in Raman measurement and size-selective permeability of the microgel matrix obviates the pretreatment of samples. To validate the functions, we demonstrate the direct detection of Aspirin dissolved in whole blood without any pretreatment.

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confidence: 63%

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confidence: 91%

Uniform Microgels Containing Agglomerates of Silver Nanocubes for Molecular Size‐Selectivity and High SERS Activity

Kim

Jeon

Park

et al. 2017

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“…The main Raman lines of ASA peaked at 557, 646–754, 787, 1045, 1157, 1192, 1260–1301, 1435, 1608, 1631, 1753, 2945, and 3076 cm −1 . They were assigned to the following vibrational modes: CO 2 rocking vibration + bending vibrations for CO 2 , torsion benzene ring, C-H out-of-plane bending, benzene breathing, C-C stretching + C–H in-plane bending in benzene, C–H in-plane bending in benzene, C-C stretching + C–H in-plane bending in benzene, O–H in-plan bending, C-C stretching in benzene ring, C=C stretching in benzene ring, C=O stretching, CH 3 asymmetrical stretching, and CH 3 symmetrical stretching, respectively [ 24 , 43 ]. According to Figure 6 b, the following changes were observed when ASA interacted with NaOH: (1) a downshift of the Raman lines from 557 cm −1 to 553 cm −1 ; (2) a change of the ratio between the intensities of Raman lines peaked at 1608 cm −1 and 557 cm −1 (I 1608 /I 557 ) or 2945 cm −1 (I 1608 /I 2945 ) from 7.5 and 5.9 to 4.62 and 2.97, respectively; and (3) an upshift of the Raman line from 3076 cm −1 to 3081 cm −1 .…”

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confidence: 99%

The Influence of UV Light on Photodegradation of Acetylsalicylic Acid

Daescu

Iota

Serbschi³

et al. 2021

IJMS

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Photodegradation of the aqueous solutions of acetylsalicylic acid, in the absence (ASA) and the presence of excipients (ASE), is demonstrated by the photoluminescence (PL). A shift of the PL bands from 342 and 338 nm to 358 and 361–397 nm for ASA and ASE in solid state and as aqueous solutions was reported. By exposure of the solution of ASA 0.3 M to UV light, a decrease in the PL band intensity was highlighted. This behavior was revealed for ASA in the presence of phosphate buffer (PB) having the pH equal to 6.4, 7, and 8 or by the interaction with NaOH 0.3 M. A different behavior was reported in the case of ASE. In the presence of PB, an increase in the intensity of the PL band of ASE simultaneously with a change of the ratio between the intensities of the bands at 361–364 and 394–397 nm was highlighted. The differences between PL spectra of ASA and ASE have their origin in the presence of salicylic acid (SAL). The interaction of ASE with NaOH induces a shift of the PL band at 405–407 nm. Arguments for the reaction of ASA with NaOH are shown by Raman scattering and FTIR spectroscopy.

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Combined host-guest complex with coffee-ring effect for constructing ultrasensitive SERS substrate for phenformin hydrochloride detection in healthcare products

Zhang

Peng

et al. 2018

Anal Bioanal Chem

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Surface enhanced Raman spectroscopic studies on aspirin : An experimental and theoretical approach

Cited by 3 publications

References 6 publications

Uniform Microgels Containing Agglomerates of Silver Nanocubes for Molecular Size‐Selectivity and High SERS Activity

Uniform Microgels Containing Agglomerates of Silver Nanocubes for Molecular Size‐Selectivity and High SERS Activity

The Influence of UV Light on Photodegradation of Acetylsalicylic Acid

Combined host-guest complex with coffee-ring effect for constructing ultrasensitive SERS substrate for phenformin hydrochloride detection in healthcare products

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