2022
DOI: 10.3390/ma15155127
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Surface Functionalisation of Dental Implants with a Composite Coating of Alendronate and Hydrolysed Collagen: DFT and EIS Studies

Abstract: The success of the osseointegration process depends on the surface characteristics and chemical composition of dental implants. Therefore, the titanium dental implant was functionalised with a composite coating of alendronate and hydrolysed collagen, which are molecules with a positive influence on the bone formation. The results of the quantum chemical calculations at the density functional theory level confirm a spontaneous formation of the composite coating on the titanium implant, ∆G*INT = −8.25 kcal mol−1… Show more

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Cited by 3 publications
(4 citation statements)
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“…The surface characterization (composition) of Ti/oxide/alendronate samples before and after immersion was performed using ATR-FTIR ( Figure 5 ). Prior to sample immersion, weak bands around 1000 cm –1 are visible characteristics for the P–O and P=O bands present in the alendronate molecule [ 16 , 56 , 57 ]. On the other hand, after immersion bands were detected in the spectral range from 900 to 1100 cm –1 , typical for the symmetric and asymmetric P–O stretching modes in the phosphate group [ 58 , 59 , 60 ].…”
Section: Resultsmentioning
confidence: 99%
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“…The surface characterization (composition) of Ti/oxide/alendronate samples before and after immersion was performed using ATR-FTIR ( Figure 5 ). Prior to sample immersion, weak bands around 1000 cm –1 are visible characteristics for the P–O and P=O bands present in the alendronate molecule [ 16 , 56 , 57 ]. On the other hand, after immersion bands were detected in the spectral range from 900 to 1100 cm –1 , typical for the symmetric and asymmetric P–O stretching modes in the phosphate group [ 58 , 59 , 60 ].…”
Section: Resultsmentioning
confidence: 99%
“…Organophosphorus compounds such as phosphonates have proven to be effective agents for the functionalization of titanium surfaces by forming homogeneous self-assembled monolayers. In particular, alendronate, a nitrogen-containing bisphosphonate, exhibits good coating properties on titanium surfaces [ 15 , 16 , 17 ], and the effect of immobilizing alendronate on the titanium surface to stimulate new bone formation and improve bone-implant integration after implantation has been widely reported [ 17 , 18 , 19 , 20 ]. On the titanium surface, alendronate molecules are covalently bound to the TiO 2 layer via phosphonate groups (-PO 3 H) [ 15 ].…”
Section: Introductionmentioning
confidence: 99%
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“…The EEC and titanium alloy | surface film interface are schematically presented in Figure 6a,b, respectively. The used EEC has previously been published for surface film-covered titanium and its alloys [46,[68][69][70][71].…”
Section: Electrochemical Characterisation Of Calcium Phosphate Coatin...mentioning
confidence: 99%