Surface functionalization of nanodiamonds for biomedical applications

Jariwala, Dhruvil Hiteshkumar; Patel, Dhrumi; Wairkar, Sarika

doi:10.1016/j.msec.2020.110996

Cited by 87 publications

(49 citation statements)

References 67 publications

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“…Two other prime sources of fluorescence in nanodiamonds include optical/vacancy centers (N-V, Si-V, Eu-V, B-V, etc.) and surface states (Jariwala et al, 2020). In the present case, while it is evident that the synthesized fNDC do not contain any induced vacancy centers, consequently, it is rational to conclude that the fluorescence of fNDC possibly arises from the surface states.…”

Section: Optical Behavior Of the Synthesized Nanodiamond-like Carbon Materialssupporting

confidence: 50%

Valorization of agro-industrial fruit peel waste to fluorescent nanocarbon sensor: Ultrasensitive detection of potentially hazardous tropane alkaloid

Ramya

Balachandran

2021

Front. Environ. Sci. Eng.

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Millions of tonnes of agro-industrial waste are generated each year globally, with the vast majority of it going untreated, underutilized, and disposed of by burning or landfilling, causing severe environmental distress and economic downturn. A practical solution to this global issue is to use green chemistry to convert this waste into value-added products. Accordingly, in the present study, agro-industrial orange peel waste was valorized into fluorescent nanodiamond-like carbon sensor via a green route involving hydrothermal treatment of microwave carbonized orange peel waste. The developed sensor, used for the fluorescence detection of potentially hazardous drug atropine sulfate, exhibits unique dual linearity over concentration ranges of 300 nM to 1 M and from 1 M to 10 M, as well as ultra-low sensitivity of 34.42 nM and 356.46 nM, respectively. Additionally, the sensor demonstrates excellent reproducibility, high stability, and satisfactory recovery when used to identify and quantify atropine sulfate in biological samples and commercially available pharmaceuticals, indicating promising multidisciplinary applications.

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Section: Optical Behavior Of the Synthesized Nanodiamond-like Carbon Materialssupporting

confidence: 50%

Valorization of agro-industrial fruit peel waste to fluorescent nanocarbon sensor: Ultrasensitive detection of potentially hazardous tropane alkaloid

Ramya

Balachandran

2021

Front. Environ. Sci. Eng.

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“…[124] Numerous techniques exist for surface modification and functionalization of NDs due to their ability to readily form covalent and noncovalent attachments with various polymers and biomolecules with functional groups able to attach. [125] Three methods for the incorporation of thiol groups onto the surface of nanodiamonds will be discussed. The first method as described by Lud et al involves the X-ray-and electron-induced modification of surface sulfonic monophenyl monolayers that have previously been covalently grafted onto the NDs surface to thiol groups.…”

Section: Thiolated Nanodiamond Particlesmentioning

confidence: 99%

Thiolated Nanoparticles for Biomedical Applications: Mimicking the Workhorses of Our Body

Hock¹,

Racaniello

Aspinall

et al. 2021

Advanced Science

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Advances in nanotechnology have generated a broad range of nanoparticles (NPs) for numerous biomedical applications. Among the various properties of NPs are functionalities being related to thiol substructures. Numerous biological processes that are mediated by cysteine or cystine subunits of proteins representing the workhorses of the bodies can be transferred to NPs. This review focuses on the interface between thiol chemistry and NPs. Pros and cons of different techniques for thiolation of NPs are discussed. Furthermore, the various functionalities gained by thiolation are highlighted. These include overall bio-and mucoadhesive, cellular uptake enhancing, and permeation enhancing properties. Drugs being either covalently attached to thiolated NPs via disulfide bonds or being entrapped in thiolated polymeric NPs that are stabilized via inter-and intrachain crosslinking can be released at the diseased tissue or in target cells under reducing conditions. Moreover, drugs, targeting ligands, biological analytes, and enzymes bearing thiol substructures can be immobilized on noble metal NPs and quantum dots for therapeutic, theranostic, diagnostic, biosensing, and analytical reasons. Within this review a concise summary and analysis of the current knowledge, future directions, and potential clinical use of thiolated NPs are provided.

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“…Detonation Diamond Nanoparticles of size around 6 nm and purity of more than 98%, Color: gray, Morphology: spherical and Bulk density: 0.17 g/cm 3…”

Section: Chemicalmentioning

confidence: 99%

“…The numeral applications of diamond nanoparticles in biological fields increased quickly through previous years and this imitated in huge investigations [1][2][3]. Several studies concentrated on pharmaceutic investigations and diagnoses of clinical applications [4].…”

Section: Introductionmentioning

confidence: 99%

Impact of Diamond Nanoparticles on the Efficiency of Vinblastine against Ehrlich Solid Carcinoma in Mice

AL-Ahmari

El-Hamidy

2021

JPRI

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Aim: This investigation pointed to estimate skeletal muscle efficiency of diamond nanoparticles in enhancing Vinblastine (VBL) effects. Methodology: One hundred Albino mice, weighing (23- 28 grams) were utilized in this research, after a week of habituation, the mice were divided into five groups at random (20 mice each). Group 1 (control) obtained distilled water infusions, Group 2 (ESC group) injected Ehrlich cells via intramuscular infusion (IM), and Group 3 (ESC+VBL group) gained Vinblastine only, Group 4 (ESC+VBL+ND) received an IM injection of Vinblastine loaded on diamond nanoparticles and Group 5 (ESC+VBL+CS+ND) received IM administration of Vinblastine stacked on Chitosan with nanodiamond. Finally, blood specimens were taken. Serum was obtained to measure Asparaginase aminotransferase, Alanine aminotransferase, and Creatinine kinase. The muscle was removed and observed under a light microscope. Results: Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and Creatinine kinase levels in the blood were elevated in ESC than in normal and treated groups. Levels of these enzymes were enhanced after treatment of VBL, diamond nanoparticles and chitosan. Conclusion: Nanodiamond are influenced in the VBL delivery system for the therapy of Ehrlich Solid carcinoma in mice models. The embattled VBL liberates tumor cells and reduced the side effect of VBL on skeletal muscle.

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Surface functionalization of nanodiamonds for biomedical applications

Cited by 87 publications

References 67 publications

Valorization of agro-industrial fruit peel waste to fluorescent nanocarbon sensor: Ultrasensitive detection of potentially hazardous tropane alkaloid

Valorization of agro-industrial fruit peel waste to fluorescent nanocarbon sensor: Ultrasensitive detection of potentially hazardous tropane alkaloid

Thiolated Nanoparticles for Biomedical Applications: Mimicking the Workhorses of Our Body

Impact of Diamond Nanoparticles on the Efficiency of Vinblastine against Ehrlich Solid Carcinoma in Mice

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