Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion

Chua, Poh-Hui; Neoh, K. G.; Kang, En‐Tang; Wang, Wilson

doi:10.1016/j.biomaterials.2007.12.019

Cited by 445 publications

(402 citation statements)

References 39 publications

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“…Furthermore, results of Chua et al showed that Chi-graft titanium substrates were better support MC3T3E-1 cell adhesion than hyaluronic acid (HA)-graft titanium and HA/Chi PEM functionalized titanium. Moreover, the immobilization of RGD peptide on the HA/ Chi PEM functionalized titanium had a significant effect on osteoblast proliferation and ALP activity while retaining high antibacterial efficacy 38) . These results indicated the importance of chemical composition on the modified surfaces on cell behavior.…”

Section: Discussionmentioning

confidence: 97%

“…As it was previously reported that the biological responses to PEM film depended on the outer layer of film 38,39) , PSS-co-MA was used as a final depositing layer of the film to evaluate its effect on osteoblast behavior. To prove of principle that PSS-co-MA influences osteoblast behaviors, (PDADMAC/PSS)4/ PDADMAC+PSS-co-MA film was fabricated on glass surface.…”

Section: Discussionmentioning

confidence: 99%

“…In terms of surface chemistry, studies suggested that nature and chemical composition of PEM films could affect adhesion and proliferation of cells cultured on the films 38,39,41,49,50) . Various cell types such as fibroblasts 41) , osteoblast-like cells (SaOS-2, MC3T3-E1) 38,39) , human periodontal ligament (PDL) cells 39) , endothelial cells 49) and various hepatocytes (human hepatocellular carcinoma cells, adult rat hepatocytes and human fetal hepatoblasts) 50) have been studied. For example, Tryoen-TÓth et al suggested that a good cell adhesion, proliferation and stability of osteoblast phenotype of PSS-and PGA-ending films for PDL cells and of PSS-, PGA-, and PLL-terminating films for SaOS-2.…”

Section: Discussionmentioning

confidence: 99%

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Differentiation of MC3T3-E1 on poly(4-styrenesulfonic acid-co-maleic acid)sodium salt-coated films

et al. 2011

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Polyelectrolyte multilayer (PEM) film can modify the surface properties of materials to improve cellular responses. In this study poly(diallyldimethylammonium chloride) (PDADMAC), poly(sodium 4-styrene sulfonate) (PSS) and poly(4-styrenesulfonic acid-comaleic acid) sodium salt (PSS-co-MA) were assembled into PEM {(PDADMAC/PSS)4/PDADMAC+PSS-co-MA} film on glass surfaces and its ability on affecting osteoblast functions were examined. PSS-co-MA film showed an increase roughness and more wettable surface as compared to glass. When the osteoblast cell line, MC3T3-E1, was seeded on the surfaces, no differences were observed in cell attachment or spreading on either PSS-co-MA film or glass at 4-16 hours. However, increases in alkaline phosphatase activity (day-5 and 7) and the expression of osteocalcin mRNA/protein at day-13 were observed. Cells cultured on PSS-co-MA film developed a faster rate of calcium deposition at day-15 compared to control. In conclusion, PSS-co-MA film enhanced osteoblast differentiation and could be used to promote mineralization and improve osseointegration for dental implants.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Differentiation of MC3T3-E1 on poly(4-styrenesulfonic acid-co-maleic acid)sodium salt-coated films

et al. 2011

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“…antibiotics, specific polymers, toxic metal ions) onto the surface of implantable devices [3][4][5][6][7]. The primary advantage of such antibacterial coatings is the release of the antibacterial agent at the site of implantation, minimizing the risk of concentrations being reached that could cause harmful side effects in other parts of the body.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Composite Layers on Ti: Role of ZnO Nanoparticles

Roguska¹,

Belcarz²,

Suchecki³

et al. 2016

Archives of Metallurgy and Materials

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Problem of post-operative infections of implant materials caused by bacterial adhesion to their surfaces is very serious. Enhancement of antibacterial properties is potentially beneficial for biomaterials value. Therefore, the metallic and metallic oxide nanoparticles attract particular attention as antimicrobial factors. The aim of this work was to create nanotubular (NT) oxide layers on Ti with the addition of ZnO nanoparticles, designed for antibacterial biomedical coatings. Antimicrobial activities of titanium, TiO 2 NT and ZnO/TiO 2 NT surfaces were evaluated against bacterial strain typical for orthopaedic infections: S. epidermidis. TiO 2 NT alone killed the free bacterial cells significantly but promoted their adhesion to the surfaces. The presence of moderate amount of ZnO nanoparticles significantly reduced the S. epidermidis cells adhesion and viability of bacterial cells in contact with modified surfaces. However, higher amount of loaded nanoZnO showed the reduced antimicrobial properties than the medium amount, suggesting the overdose effect.

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“…However, the osseointegration and osteoconductive properties of Ti based implants are essentially limited. In addition, Ti based implants encounter specific complications associated with its incorporation and stability at the host interface, because of limited cell adhesion and the implants susceptibility to bacterial infections [3]. Hence, recent researches have been focused on improving surface treatments to promote osseointegration and osteoconductive properties of Ti based implants.…”

Section: Introductionmentioning

confidence: 99%

Research Progress on the Biochemical Modification of Titanium Implant Surface

Mao¹

2014

Med chem

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Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion

Cited by 445 publications

References 39 publications

Differentiation of MC3T3-E1 on poly(4-styrenesulfonic acid-co-maleic acid)sodium salt-coated films

Differentiation of MC3T3-E1 on poly(4-styrenesulfonic acid-co-maleic acid)sodium salt-coated films

Antibacterial Composite Layers on Ti: Role of ZnO Nanoparticles

Research Progress on the Biochemical Modification of Titanium Implant Surface

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