Surface functionalization via PEO coating and RGD peptide for nanostructured titanium implants and their in vitro assessment

Парфенов, Е.В.; Parfenova, Lyudmila V.; D’yakonov, G. S.; Данилко, К. В.; Mukaeva, V. R.; Фаррахов, Р. Г.; Lukina, E. S.; Valiev, Ruslan Z.

doi:10.1016/j.surfcoat.2018.10.068

Cited by 35 publications

(22 citation statements)

References 68 publications

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“…Our recent study [15] showed that the combination of the PEO coating and RGD-modified bisphosphonic acid on nano-Ti gives a 45% increase in the number of proliferated cells compared to uncoated nano-Ti, and 66% compared to coarse grain Ti.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Organic Coatings Based on Bisphosphonic Acid RGD-Derivatives for PEO-Modified Titanium Implants

et al. 2020

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Currently, significant attention is attracted to the problem of the development of the specific architecture and composition of the surface layer in order to control the biocompatibility of implants made of titanium and its alloys. The titanium surface properties can be tuned both by creating an inorganic sublayer with the desired morphology and by organic top coating contributing to bioactivity. In this work, we developed a composite biologically active coatings based on hybrid molecules obtained by chemical cross-linking of amino acid bisphosphonates with a linear tripeptide RGD, in combination with inorganic porous sublayer created on titanium by plasma electrolytic oxidation (PEO). After the addition of organic molecules, the PEO coated surface gets nobler, but corrosion currents increase. In vitro studies on proliferation and viability of fibroblasts, mesenchymal stem cells and osteoblast-like cells showed the significant dependence of the molecule bioactivity on the structure of bisphosphonate anchor and the linker. Several RGD-modified bisphosphonates of β-alanine, γ-aminobutyric and ε-aminocaproic acids with BMPS or SMCC linkers can be recommended as promising candidates for further in vivo research.

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Section: Introductionmentioning

confidence: 99%

Biocompatible Organic Coatings Based on Bisphosphonic Acid RGD-Derivatives for PEO-Modified Titanium Implants

et al. 2020

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“…101,102) The majority of implant materials, both conventional as titanium, and prospective as magnesium and zirconium, belong to a group of so-called valve metals that can be easily coated with the PEO technique. 103,104) Currently, PEO is extensively researched 13,98,105,106) The PEO process is an expansion of the traditional anodizing into the high voltages up to 600 V; these voltages promote microdischarges within the coating; this results in its resolidifying and intensive growth. 107109) The coatings obtained by this method contain stable titania (rutile and anatase) tightly attached to the surface because of the process mechanism which includes electrochemical oxidation and numerous melting and crystallizing events at the microdischarge sites (Fig.…”

Section: Surface Modification Of Nanometals For Implant Applicationsmentioning

confidence: 99%

“…112,113) As it was shown recently, nano Ti coated with the PEO technique has finer structure, contains more biocompatible compounds and shows higher cell adhesion compared to the coating on CG Ti. 98) For the orthopedic applications, the PEO coating opens possibilities to develop an "ideal coating". This coating provides enhanced biocompatibility due to following the biomimetic approach at physical, chemical and biological levels.…”

Section: Surface Modification Of Nanometals For Implant Applicationsmentioning

confidence: 99%

“…This coating provides enhanced biocompatibility due to following the biomimetic approach at physical, chemical and biological levels. 98,114) At physical level, a gradual change of the elasticity modulus from the metallic implant to the bone is achieved because the wide network of the pores forms a fractal-like structure, with the pore size increasing to the top of the coating. 112) Unlike other methods, for the PEO there is no need to create a surface with high roughness.…”

Section: Surface Modification Of Nanometals For Implant Applicationsmentioning

confidence: 99%

“…122) A recent study of nanostructured titanium subjected to PEO and further modification with RGD containing peptide showed significant improvement of all the crucial implant properties: strength, corrosion resistance and biocompatibility. 98) Therefore, the research into the development of the biocompatible coatings on nanostructured implants by PEO is an actual problem of the modern engineering and technologies.…”

Section: Surface Modification Of Nanometals For Implant Applicationsmentioning

confidence: 99%

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Developing Nanostructured Metals for Manufacturing of Medical Implants with Improved Design and Biofunctionality

2019

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Recent years have witnessed a series of numerous investigative activities to improve existing metallic biomaterials (Ti and Ti alloys, stainless steels, Mg and Fe alloys) by their nanostructuring for advanced medical applications using severe plastic deformation (SPD) processing. Nanostructured metals are peculiar for their enhanced strength and fatigue life, which makes them an excellent choice for fabrication of implants with improved design for dentistry and orthopedics. Moreover, surface modification of nanometals by chemical etching and bioactive coatings show a significant improvement of biomedical properties. Various studies conducted in this field make it possible to fabricate miniaturized dental implants and nanoTi plates with enhanced osseointegration.

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Nanostructured Bulk Titanium with Enhanced Properties—Strategies and Prospects for Dental Applications

Sotniczuk

Garbacz

2021

Adv Eng Mater

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Society is aging fast. The percentage of people aged above 65 years is forecast to rise from 12.4% (in 2000) to 23% by 2100. [1] The figures for 2030 for Europe and the United States are %20% and 30% respectively. [2] At present, almost 23% of US citizens over 65 are completely edentulous, creating great demand for dental replacements. [3] According to the compound annual growth rate (CAGR) forecast, the global dental market is expected to exceed $8 billion by the end of 2024, up from $4.46 billion in 2016. [1] Moreover, with rising life expectancy, modern implants have to serve much longer without requiring revision surgery. This is challenging, especially in the case of elderly people, who tend to suffer diseases that increase the risk of implant rejection. [2] Thus, advanced healthcare requires constant development in the design and fabrication of dental materials. Currently, commercially pure titanium (CP-Ti) is a leading metallic material in the global dental replacements market. [4] This is mainly due to its biocompatibility and high resistance to corrosion in body fluids. Those properties are governed by the presence of a passive layer on Ti surface, created by its strong tendency to oxidize. [5] Nanostructuring by large plastic deformation techniques is a promising approach to altering Ti properties that are essential for dental applications. [1,[6][7][8][9][10] While clinical trials have confirmed the successful application of dental implants fabricated from nanocrystalline Ti, [4,9] works are still ongoing to develop strategies aimed at enhancing biological response and antibacterial properties without impacting mechanical properties. [11][12][13][14] In this Review, we describe recent approaches taken to modify the properties of nanocrystalline Ti for biomedical applications. Our study focuses on the following aspects: (i) improving biomedical nano Ti properties through bulk and surface modifications, and (ii) the effect of microstructural changes induced by processing of nano Ti on the results of modifications. This analysis is prefaced by a brief description of the effect of nanostructure on Ti mechanical and functional properties.

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Surface functionalization via PEO coating and RGD peptide for nanostructured titanium implants and their in vitro assessment

Cited by 35 publications

References 68 publications

Biocompatible Organic Coatings Based on Bisphosphonic Acid RGD-Derivatives for PEO-Modified Titanium Implants

Biocompatible Organic Coatings Based on Bisphosphonic Acid RGD-Derivatives for PEO-Modified Titanium Implants

Developing Nanostructured Metals for Manufacturing of Medical Implants with Improved Design and Biofunctionality

Nanostructured Bulk Titanium with Enhanced Properties—Strategies and Prospects for Dental Applications

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