Surface hemocompatible modification of polysulfone membrane <i>via</i> covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan

Tu, Ming-Ming; Xu, Junjie; Qiu, Yunren

doi:10.1039/c8ra10573a

Cited by 24 publications

(16 citation statements)

References 40 publications

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“…Plasma recalcation time was a test on endogenous coagulation, playing a significant role on anticoagulant [21]. For platelet-poor plasma (PPP), the collection of fresh blood was placed in a centrifuge at 3000 r.p.m.…”

Section: Plasma Recalcation Timementioning

confidence: 99%

“…But the few reaction sites of C6 in CS prevented the better biocompatibility, and neutral hydroxyl groups failed to form a synergistic effect in anticoagulation with the sulfonic groups to promote the haemocompatibility. Tu et al [21] developed the bridge with acrylic acid and then grafted SHPCS with hydroxyl and sulfonic groups at the pretreated PSF membranes to improve the hydrophilicity and anticoagulation. Yan et al [22] optimized the modification process of chlorine bridge by 4-(chloromethyl)benzoic acid in the pretreatment of PSF membranes to suffer more active sites for SHPCS.…”

Section: Introductionmentioning

confidence: 99%

“…Tu et al . [21] developed the bridge with acrylic acid and then grafted SHPCS with hydroxyl and sulfonic groups at the pretreated PSF membranes to improve the hydrophilicity and anticoagulation. Yan et al .…”

Section: Introductionmentioning

confidence: 99%

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Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility

2021

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Polysulfone (PSF) works potentially in haemodialysis due to its great mechanical and chemical stability, but performs poorly in haemocompatibility. For promoting the unpleasant haemocompatibility, sulfonated citric chitosan (SCACS) with the structure and groups similar to heparin was primarily synthesized by acylation and sulfonation. Furthermore, the chloroacylated PSF was pretreated by electrophilic chloroacetyl chloride to achieve more active sites for further reaction; the following membranes underwent the amination and were named amination polysulfone (AMPSF) membranes. Moreover, SCACS with abundant carboxyl and sulfonic groups was covalently grafted at the surface of pretreated PSF membranes, called PSF-SCACS membranes. The PSF-SCACS membranes were successfully synthesized and characterized by 1 H NMR, ATR-FTIR and XPS. In addition, the water contact angle of PSF-SCACS membranes decreased by 47° and the morphologies of the membranes changed little compared with the unmodified PSF membranes. The haemocompatible testing results, including protein adsorption, platelet adhesion, haemolysis rate, plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT), demonstrated that the PSF-SCACS membranes possessed excellent haemocompatible performances, and SCACS played an important role in the modification.

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Section: Plasma Recalcation Timementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility

2021

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“…In hemodialysis, a semipermeable membrane is the most vital component responsible for the separation of substances. The early generation type of this membrane was made of acetic cellulose, which then has been replaced by a synthetic polymer, such as polysulfone (PSF), polyethersulfone (PES), polyvinylpyrrolidone (PVP), polymethylmethacrylate (PMMA), and polyacrylonitrile (PAN) [2][3][4][5]. Although the early generation and the synthetic polymer types have small pores and are good in transporting urea and creatinine compounds, there are still some problems concerning their permeability and biocompatibility [6].…”

Section: ■ Introductionmentioning

confidence: 99%

Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane

2021

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This study aims to examine the manufacture, characterization, and in vitro hemocompatibility of glutaraldehyde-crosslinked chitosan/carboxymethyl cellulose (CS/CMC-GA) as a hemodialysis membrane. The CS/CMC-GA membrane was prepared using the phase inversion method with 1.5% CS and 0.1% CMC. The chitosan was crosslinked with glutaraldehyde in various monomers ratios, and the membranes formed were characterized by FTIR, SEM, and TGA. Furthermore, the hydrophilicity, swelling, porosity, mechanical strength, and dialysis performance of the membranes against urea and creatinine were systematically examined, and their in-vitro hemocompatibility tests were also conducted. The results showed that the CS/CMC-GA membranes have higher hydrophilicity, swelling, porosity, mechanical strength, and better dialysis performance against urea and creatinine than chitosan without modification. In addition, the hemocompatibility test indicated that the CS/CMC-GA membranes have lower values of protein adsorption, thrombocyte attachment, hemolysis ratio, and partial thromboplastin time (PTT) than that of pristine chitosan. Based on these results, the CC/CMC-GA membranes have better hemocompatibility and the potential to be used as hemodialysis membranes.

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“…There are quite lot intermediates having multiple reactive functionalities which tie up the bare biomaterial surface with and expedite the subsequent immobilization of albumin. Dopamine is the most accepted bonding material for protein immobilization although a few other intercessors such as poly(Nvinyl-2-pyrrolidone) (PVP) and poly(acrylic acid) have been recently proven worthwhile [18,19]. The ease of its polymerization and formation of a stable overlay of polydopamine over any kind of membrane surface regardless of the physicochemical and morphological features of the membrane rendered dopamine and polydopamine as the excellent choice of precursors for protein immobilization.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the potency of leukodepletion filter membranes immobilized with bovine serum albumin via polydopamine spacer

2020

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Conjugation of biomolecules over membrane surfaces intended for blood contacting applications has been proven worthwhile for the improvement of their hemocompatibility. In conjunction with this factuality, this manuscript for the first time unveils the feasibility of bovine serum albumin (BSA) immobilization via polydopamine precursors on electrospun poly(ethylene-co-vinyl alcohol) (EVAL) leukodepletion filter membranes. The successful immobilization of different extents of BSA on EVAL membranes was endorsed by the Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) Spectrum, variations in the wettability, electron microscopic images revealing the alterations in the fiber diameter and porousness of membranes. An interesting backlash was encountered in the in vitro plasma protein adsorption and in vitro platelet adhesion on the BSA-immobilized membranes as they exhibited a higher protein adsorption and lower platelet adhesion in comparison with neat EVAL. The infiltration of immobilized BSA to the leukodepletion capacity of those membranes was preliminarily studied by in vitro blood-material interactions followed by typical whole blood filtration of selected membranes. The data presented highlight that BSA moieties do not particularly affect the white blood cell (WBC) adhesion and platelet adhesion of EVAL membranes whereas resulted in a significantly higher red blood cell (RBC) recovery and decreased hemolysis under in vitro conditions. Accordingly, BSA-immobilized EVAL membranes were made to asymmetric leukodepletion filters; however, their further evaluation by whole blood filtration ensued that immobilization of BSA could not particularly enhance the overall whole blood leukodepletion efficacy of EVAL membranes.

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Surface hemocompatible modification of polysulfone membrane via covalently grafting acrylic acid and sulfonated hydroxypropyl chitosan

Abstract: In this study, acrylic acid (AA) and sulfonated hydroxypropyl chitosan (SHPCS) were covalently grafted on the PSf membrane surface to improve its hemocompatibility.

Cited by 24 publications

References 40 publications

Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility

Preparation of modified polysulfone material decorated by sulfonated citric chitosan for haemodialysis and its haemocompatibility

Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane

Investigation of the potency of leukodepletion filter membranes immobilized with bovine serum albumin via polydopamine spacer

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