Surface immobilization of biocompatible phospholipid polymer multilayered hydrogel on titanium alloy

Choi, Jiyeon; Konno, Tomohiro; Matsuno, Ryosuke; Takai, Madoka; Ishihara, Kazuhíko

doi:10.1016/j.colsurfb.2008.08.025

Cited by 48 publications

(31 citation statements)

References 39 publications

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“…Other segments in such a block-type polymer play an important role in attaching the poly(MPC) segment to the substrate [31,40]. Layer-by-layer molecular integration is also applicable for modifying the substrate with MPC polymers [41][42][43].…”

Section: Coating Of Artificial Materials With Mpc Polymersmentioning

confidence: 99%

Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces

Iwasaki

Ishihara

2012

Science and Technology of Advanced Materials

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216

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This review article describes fundamental aspects of cell membrane-inspired phospholipid polymers and their usefulness in the development of medical devices. Since the early 1990s, polymers composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) units have been considered in the preparation of biomaterials. MPC polymers can provide an artificial cell membrane structure at the surface and serve as excellent biointerfaces between artificial and biological systems. They have also been applied in the surface modification of some medical devices including long-term implantable artificial organs. An MPC polymer biointerface can suppress unfavorable biological reactions such as protein adsorption and cell adhesion -in other words, specific biomolecules immobilized on an MPC polymer surface retain their original functions. MPC polymers are also being increasingly used for creating biointerfaces with artificial cell membrane structures.

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Section: Coating Of Artificial Materials With Mpc Polymersmentioning

confidence: 99%

Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces

Iwasaki

Ishihara

2012

Science and Technology of Advanced Materials

Self Cite

261

216

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“…Jiang et al [155] brought together dark field images and SERS taking advantage of Au modified nanorods. Raman reporter molecules were chemically attached to the nanorods through Au-S or Au-N interactions.…”

Section: Probing Surface Functionalizationmentioning

confidence: 99%

“…For example, the deposition of LbL films of a phospholipid polymer PMVB (synthesized from 2-methacrylocyloxyethyl phosphorylcholine, n-butyl methacrylate, and 4-vinylphenylboronic acid) and poly(vinyl alcohol) (PVA) on Ti substrates was performed for improving the biocompatibility of implants [155], and adsorption was confirmed using ATR-FTIR spectra taken from the outer layer during film fabrication. The PMBV/PVA LbL films on the Ti substrate suppressed the adhesion of L929 cells (cultured in a culture medium -D-MEM Gibco), compared with that on an untreated Ti, being therefore promising for improving biocompatibility of Ti-based medical devices.…”

Section: Probing Surface Functionalizationmentioning

confidence: 99%

Vibrational spectroscopy for probing molecular-level interactions in organic films mimicking biointerfaces

Volpati

Aoki

Aléssio

et al. 2014

Advances in Colloid and Interface Science

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“…The LBL thin film fabrication technique has been introduced by Decher and others for surface modification with molecular-level thickness control. [3][4][5] This method can be described as controlled coordination or stepwise self-assembly strategy based on the alternate adsorption of two or more materials, driven by electrostatic interactions, hydrogen bonding, charge transfer, covalent bonding and so forth [6][7][8][9] , to form integrated, well-organized superstructure films on solid surfaces, providing a simple, relatively fast and considerably economic approach for the construction of nano-scaled 3-D architectures with various properties at mild condition.…”

Section: Introductionmentioning

confidence: 99%

Layer-by-Layer Building up of Redox Phospholipid Polymer Hydrogel Electrode for Biosensor

Konno

Takai

et al. 2011

Trans. Mat. Res. Soc. Japan

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The 3-dimensional hydrogel structure consisted of phospholipid polymer with electron mediator integrates the advantages of loading higher density enzyme and preventing biofouling as biosensor electrode. A layer-by-layer (LBL) building up process of redox polymer hydrogel electrode based on two water-soluble polymers is carried out in this study. Poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate-co-p-vinylphenylboronic acid-co-vinylferrocene) was synthesized as redox phospholipid polymer through radical polymerization. The LBL hydrogel film was formed on Au electrode pretreated with alkyl mercaptan and a photoreactive polymer, by immersing the electrode into PMBVF and poly(vinyl alcohol) aqueous solution alternately. The formation of swelling hydrophilic film was validated by atomic force microscope and contact angle measurement. The thickness of polymer layer increased linearly with the number of the LBL cycles. And cyclic voltammetry was employed to characterize the electrochemical property of the hydrogel multilayer. The characteristics were depended on the ratio of ferrocene units in the polymer, as well as the number of bilayers. The results can make developing well-defined interface for the amperometric biosensors.

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Surface immobilization of biocompatible phospholipid polymer multilayered hydrogel on titanium alloy

Cited by 48 publications

References 39 publications

Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces

Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces

Vibrational spectroscopy for probing molecular-level interactions in organic films mimicking biointerfaces

Layer-by-Layer Building up of Redox Phospholipid Polymer Hydrogel Electrode for Biosensor

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