Surface immunoglobulin positive lymphocytes in human breast cancer tissue and homolateral axillary lymph nodes

Abstract

Surface immunoglobulins were determined on human lymph node lymphocytes by the use of immunofluorescence technique in 59 breast cancer patients undergoing radical mastectomy. In 10 of these cases, lymphocyte surface immunoglobulins were also studied on lymphocytes infiltrating the primary cancer mass. The most outstanding finding was a difference between the IgM lymphocyte populations in the lymph nodes of patients with and without lymph node metastases. When cancer tissue was present in one or more lymph nodes, the tumor‐free as well as the tumor‐positive nodes showed a higher percentage of IgM positive lymphocytes than did lymph nodes from patients without nodal metastases. The greatest difference was found when IgM lymphocytes from tumor‐bearing lymph nodes were compared with those from the lymph nodes of patients without nodal metastases (p < .005). The lymphocyte populations infiltrating 5 of the 10 primary cancer masses studied showed no surface immunoglobulins; in the remainder, both IgG and IgM positive lymphocytes were found but in variable proportions. While the findings are not definitive, this is the first study dealing with the quantitation of immunoglobulin specific lymphocytes in the lymph nodes and tumor tissue of patients with breast cancer.

Human regional tumour lymph nodes: alterations of micro-architecture and lymphocyte subpopulations

“…This disagrees with Burtin et al (1969) who found IgA to be predominant in tumourdraining nodes. Again, tumour spread to the axilla did not increase the percentage of the IgM-bearing lymphocyte subpopulations in our study, and contrasts with the findings of Richters & Kaspersky (1975). There was, however, a reversal of the IgA:IgD ratio in tumour-free axillary lymph nodes where axillary spread of tumour had occurred.…”

“…Black et al, 1953;Wartman, 1959;Hamlin, 1968;Silverberg et al, 1970). Recently, alterations of lymphocyte subsets have also been described in tumour-draining lymph nodes (Richters & Kaspersky, 1975;Tsakraklides et al, 1975a;Eremin et al, 1976;Saxon & Portis, 1977).…”

Comparative analysis of primary hepatocellular carcinoma with single and multiple lesions by iTRAQ-based quantitative proteomics

“…The tumor microenvironment (TME) is the soil to develop tumors, and has an extremely important role in the tumorigenesis, development and prognosis of cancers [47,48]. The disorder of the liver environment could cause various problems, such as abnormal angiogenesis, destruction of extracellular matrix (ECM), and severe inflammation [49][50][51][52][53]. Therefore, the disorder of the TME might be one of the key factors for carcinogenesis and progression of the primary HCC with multiple lesions.…”

Significant Prognostic Factors in Breast Cancer of Japanese Women : Special Reference to Nuclear Grade and Sinus Histiocytosis

“…evaluating NG twice in the same patients at different tines obtained a coincidence of over 90 percent of the cases. According to Cutler et al (1966) Tsakraklides (1974) and his associates claimed that the patients whose lymph nodes showed a predominance of lympho cytes and germinal centers had a favorable prognosis; in these the host defensive immune response was playing a significant role (Sherwin and Richters 1972;Richters and Kaspersky 1975). Their classification seems to be reasonable from a newly established immunological point of view .…”