Surface-imprinted magnetic nanoparticles for the selective enrichment and fast separation of fluoroquinolones in human serum

Abstract

Surface enrofloxacin-imprinted magnetic nanoparticles were prepared for the selective recognition and fast separation of fluoroquinolones in human serum by surface-initiated reversible addition fragmentation chain transfer polymerization. The surface morphology and imprinted behavior were investigated and optimized. The living/controlled nature of reversible addition-fragmentation chain transfer polymerization reaction allowed the successful construction of well-defined imprinted polymer layer outside the Fe O core. Such molecularly imprinted polymers exhibited superparamagnetic properties and specific recognition toward fluoroquinolones. Combined with reversed-phase high-performance liquid chromatography, the prepared molecularly imprinted polymers were used for the selective enrichment and analysis of fluoroquinolones in human serum samples. The recoveries of four fluoroquinolones were 86.8-95.3% with relative standard deviations of 2.0-6.8% (n = 3). Such magnetic molecularly imprinted polymers have great prospects in the separation and enrichment of trace analysts in complex biological samples.

Molecularly imprinted polymer coating on metal‐organic frameworks for solid‐phase extraction of fluoroquinolones from water

“…As shown in Figure A, the adsorption capacity of MIP@UiO‐66‐NH 2 and NIP@UiO‐66‐NH 2 increased with increasing ENRO concentration, and the maximum adsorption capacity was 99.19 and 33.60 mg/g for MIP@UiO‐66‐NH 2 and NIP@UiO‐66‐NH 2 , respectively. The adsorption capacity was much higher than that reported in the literature . Moreover, the adsorption capacity did not change with increasing ENRO concentration.…”

“…The adsorption rate is an essential property of MIP@UiO‐66‐NH 2 for fast separation in practical applications. As shown in Figure B, the adsorption rate for ENRO was very fast, and the adsorption equilibrium was reached at 65 s, which is much faster than traditional MIPs and other core materials . As in the static adsorption experiment, the adsorption capacity of MIP@UiO‐66‐NH 2 was higher than that of NIP@UiO‐66‐NH 2 , indicating that MIP@UiO‐66‐NH 2 had adsorption properties specific to ENRO.…”

Photoirradiation surface molecularly imprinted polymers for the separation of 6‐O‐α‐d‐maltosyl‐β‐cyclodextrin

“…However, conventional methods for preparing MIPs have some drawbacks, such as heterogeneous recognition sites, larger diffusion barriers, low adsorption capacity, and poor rebinding capacity . To overcome these problems, studies have investigated molecular imprinting on the surfaces of various materials . Molecular imprinting on the surface of inorganic materials such as silica provides one of the best supports because it shows stable physicochemical properties and controllable pore sizes .…”