Surface-initiated atom transfer radical polymerization: A new method for preparation of polymeric membrane adsorbers

Singh, Namrata; Wang, Jun; Ulbricht, Mathias; Wickramasinghe, S. Ranil; Husson, Scott M.

doi:10.1016/j.memsci.2007.10.007

Cited by 140 publications

(91 citation statements)

References 29 publications

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“…95 Moreover, the ATPR reaction can be achieved under environmentally friendly conditions using water as the solvent. 96 Cross-linking is usually achieved by covalently cross-linking polymers that are adsorbed on the LDH surface via a crosslinked agent (e.g. glutaraldehyde).…”

Section: Ldh@polymermentioning

confidence: 99%

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

2015

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a Layered double hydroxide (LDH)-based nanocomposites, constructed by interacting LDH nanoparticles with other nanomaterials (e.g. silica nanoparticles and magnetic nanoparticles) or polymeric molecules (e.g. proteins), are an emerging yet active area in healthcare, environmental remediation, energy conversion and storage.Combining advantages of each component in the structure and functions, hierarchical LDH-based nanocomposites have shown great potential in biomedicine, water purification, and energy storage and conversion.This feature article summarises the recent advances in LDH-based nanocomposites, focusing on their synthesis, structure, and application in drug delivery, bio-imaging, water purification, supercapacitors, and catalysis.

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Section: Ldh@polymermentioning

confidence: 99%

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

2015

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“…The contrasting effect of grafting density for resin and membrane substrates may be explained by their structural differences: for membranes, the polymer chains with adsorptive functionalities (binding sites) are grafted from the surface of macropores; thus, controlled grafting of longer polymer chains (100-200 nm) (Bhut et al, 2008;Singh et al, 2008) in a macroporous membrane substrate does not reduce the pore diameter drastically. As long as the spacing between grafted polymer chains is sufficient, the accessibility of proteins to the binding site is not hindered.…”

Section: Dynamic Binding Capacity Of Iggmentioning

confidence: 99%

“…Polymeric tentacles with adsorptive functionality extend into the protein solution that fills the porous volume, providing a scaffold for protein molecules to adsorb. A variety of resin beads for column chromatography (Bowes et al, 2009;Franke et al, 2010;Ghose et al, 2007;Langford et al, 2007;Müller, 1986;Tao and Carta, 2008;Zhang and Sun, 2002) and macroporous membranes for membrane chromatography (Balachandra et al, 2003;Bhut et al, 2008;Bhut and Husson, 2009;He and Ulbricht, 2008;Singh et al, 2008;Tsuneda et al, 1995) have been modified with adsorptive polymeric tentacles. Incorporating polymeric tentacles into macroporous membranes has even greater importance since the surface area per volume of the membrane is much lower than a bed of resin particles (Bhut et al, 2010;Wang et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…The separation performance of a membrane adsorber depends on the chemistry and architecture of the adsorptive layer, physical properties of the base membrane and membrane module design (Charcosset, 1998;Ghosh, 2002;Roper and Lightfoot, 1995;Singh et al, 2008;Thömmes and Kula, 1995;Wang et al, 2009;Zeng and Ruckenstein, 1999). Membranes with a high density of adsorptive sites are essential for high-throughput chromatography.…”

Section: Introductionmentioning

confidence: 99%

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The role of polymer nanolayer architecture on the separation performance of anion‐exchange membrane adsorbers: I. Protein separations

Bhut

Weaver

Carter

et al. 2011

Biotech & Bioengineering

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This contribution describes the preparation of strong anion-exchange membranes with higher protein binding capacities than the best commercial resins. Quaternary amine (Q-type) anion-exchange membranes were prepared by grafting polyelectrolyte nanolayers from the surfaces of macroporous membrane supports. A focus of this study was to better understand the role of polymer nanolayer architecture on protein binding. Membranes were prepared with different polymer chain graft densities using a newly developed surface-initiated polymerization protocol designed to provide uniform and variable chain spacing. Bovine serum albumin and immunoglobulin G were used to measure binding capacities of proteins with different size. Dynamic binding capacities of IgG were measured to evaluate the impact of polymer chain density on the accessibility of large size protein to binding sites within the polyelectrolyte nanolayer under flow conditions. The dynamic binding capacity of IgG increased nearly linearly with increasing polymer chain density, which suggests that the spacing between polymer chains is sufficient for IgG to access binding sites all along the grafted polymer chains. Furthermore, the high dynamic binding capacity of IgG (>130 mg/mL) was independent of linear flow velocity, which suggests that the mass transfer of IgG molecules to the binding sites occurs primarily via convection. Overall, this research provides clear evidence that the dynamic binding capacities of large biologics can be higher for well-designed macroporous membrane adsorbers than commercial membrane or resin ion-exchange products. Specifically, using controlled polymerization leads to anion-exchange membrane adsorbers with high binding capacities that are independent of flow rate, enabling high throughput. Results of this work should help to accelerate the broader implementation of membrane adsorbers in bioprocess purification steps.

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“…The nonlinear growth behavior has been described for other polyacids, including poly (methacrylic acid), and results from chain termination reactions, as well as catalyst deactivation. 27,28 Add alkali salt in the reaction system, such as NaCl, which suppresses the ion-exchange reactions that otherwise lead to complexation between the catalyst and monomer and the dissociation of the Cu(II) species that forms during the ATRP process. Thus, catalyst deactivation can be excluded, and the non-linear growth observed for our system is most likely attributed to bimolecular chain termination.…”

Section: Kinetics Of the Atrp Grafting Processmentioning

confidence: 99%

Surface initiated ATRP of acrylic acid on dopamine‐functionalized AAO membranes

Wang

Liao

et al. 2010

J of Applied Polymer Sci

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A facile method for surface-initiated atom transfer radical polymerization (ATRP) on the anodic aluminum oxide (AAO) membranes has been developed. The AAO membrane was firstly functionalized by poly (dopamine), the bromoalkyl initiator was then immobilized on the poly(dopamine) functionalized AAO membrane surface in a two-step solid-phase reaction, followed by ATRP of acrylic acid in a aqueous solution. The poly (acrylic acid) (PAAc)-grafted AAO membranes were characterized by X-ray photoelectron spectroscopy, fourier transform infrared spectroscopy and scanning electron microscopy. The XPS and FTIR results indicated that PAAc was successfully grafted on the AAO membrane surface. The degree of grafting increases linearly with the increase of monomer concentration, and it reaches a plateau when the reaction time up to 4 h. The results indicate that the thickness of the grafted polymer inside the isocylindrical pores of AAO membranes could be well controlled by changing the reaction time and monomer concentration.

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Surface-initiated atom transfer radical polymerization: A new method for preparation of polymeric membrane adsorbers

Cited by 140 publications

References 29 publications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications

The role of polymer nanolayer architecture on the separation performance of anion‐exchange membrane adsorbers: I. Protein separations

Surface initiated ATRP of acrylic acid on dopamine‐functionalized AAO membranes

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