Surface Modification−Complexation Strategy for Cisplatin Loading in Mesoporous Nanoparticles

Abstract

High-density carboxyl groups have been successfully grafted onto the pore surface of mesoporous nanocarriers which served to complex with platinum atoms in cisplatin, leading to much increased drug loading efficiency, distinctly prolonged and pH-responsive cisplatin release, and greatly enhanced growth inhibition effect against MCF-7 and HeLa cancer cell lines.

Shape-Mediated Biological Effects of Mesoporous Silica Nanoparticles

“…All these efforts can be attributed to the attractive features of MSNs, such as high pore volume for increasing loading capacity, long-range ordered pore channel for sustained drug release, well monodispersity for longer circulation time, and facile scalable production for clinical and commercial demands. For optimizing the design parameters of drug nanocarriers, in the past couple of years, researchers have paid a great attention to the effect of physicochemical characters, such as pore properties, [247][248][249][250] and surface chemistry, [251][252][253][254][255][256] on drug delivery efficacy. In 2011, Meng et al first employed different ARs particles as nanocarriers to load two hydrophobic anticancer drugs, camptothecin and paclitaxel, and research the AR effect on the cytotoxicity of Hela cells.…”

Silica xerogels and hydroxyapatite nanocrystals for the local delivery of platinum–bisphosphonate complexes in the treatment of bone tumors: A mini-review

“…Silica based bioactive xerogels have been exploited for the entrapment and slow release of platinum drugs [45][46][47]. In particular, Czarnobaj and coworkers reported silica xerogels, obtained by the sol-gel method, loaded with cisplatin before (predoping method) or after (postdoping method) the formation of the hard xerogel [48].…”

Platinum on Nanodiamond: A Promising Prodrug Conjugated with Stealth Polyglycerol, Targeting Peptide and Acid‐Responsive Antitumor Drug

“…[ 19 ] In this context, it is proposed that polyglycerol (PG) [ 20 ] is a better alternative to PEG for biomedical applications of nanoparticle [ 21 ] in terms of biocompatibility, solubility and stability in physiological environment, and extensibility for further chemical derivatization. [ 19,29,30 ] To take advantage of the above characteristics of PG, PG-coating has been extensively applied quite recently to nanoparticles such as superparamagnetic iron oxide nanoparticle, [ 25,31,32 ] silica-encapsulated iron oxide nanoparticle, [ 33 ] nanodiamond (ND), [ 24,[34][35][36] zinc oxide nanoparticle, [ 26 ] carbon nanotubes, [37][38][39][40] quantum dots, [ 41 ] Fe@ Au nanoparticles [ 42 ] and mesoporous silica nanoparticles, [ 43 ] and even stem cell. [ 19,29,30 ] To take advantage of the above characteristics of PG, PG-coating has been extensively applied quite recently to nanoparticles such as superparamagnetic iron oxide nanoparticle, [ 25,31,32 ] silica-encapsulated iron oxide nanoparticle, [ 33 ] nanodiamond (ND), [ 24,[34][35][36] zinc oxide nanoparticle, [ 26 ] carbon nanotubes, [37][38][39][40] quantum dots, [ 41 ] Fe@ Au nanoparticles [ 42 ] and mesoporous silica nanoparticles, …”