Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system

Storm, Gert; Belliot, Sheila O.; Daemen, Toos; Lasiç, Danilo D.

doi:10.1016/0169-409x(95)00039-a

Cited by 810 publications

(543 citation statements)

References 77 publications

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“…This is a widely used method to recognize the surface charges of NPs (Ratner et al, 1987;Soppimath et al, 2001). Hydrophobicity and hydrophilicity determined by Water contact angle measurements and hydrophobic interaction chromatography respectively (Storm et al, 1995;Manuela Gaspar et al, 1998;Mosqueira et al, 2001;Prior et al, 2002;Avgoustakis et al, 2002;. There are many sensitive methods for characterizing nanoparticles, depending upon the factor being investigated (Dinarvand et al, 2011).…”

Section: Nanoparticle Characterization Techniquesmentioning

confidence: 99%

“…However, depending on their surface characteristics, nanoparticles will be taken up by the liver, spleen, and other parts of the reticuloendothelial system (RES) (Nie et al, 2007;Mozafari et al, 2009). Surface modification of nanoparticles is significant for escaping the body's natural defense systems when transporting drugs to the bloodstream (Storm et al, 1995;Dinarvand et al, 2011). A long circulation time increases the chance that the nanoparticles will reach their target.…”

Section: Surface Modification Of Plga Nanoparticlesmentioning

confidence: 99%

“…These strategies comprise coating of nanoparticles with Tween 80 (Gelperina et al, 2002), PEG (polyethylene glycol) (Tang et al, 2007), PEO (polyethylene oxide) (Soppimath et al, 2001), poloxamers and poloxamines (Moghimi and Hunter, 2000;Mozafari et al, 2009), polysorbate 80, TPGS and polysaccharides like dextran (Stolnik et al, 1995;Torchilin and Trubetskoy, 1995;Mahapatro and Singh, 2011). Hydrophilic polymers can be useful at the surface of NPs by adsorption of surfactants or by utilize of block copolymers or branched copolymers (Stolnik et al, 1995;Storm et al, 1995;Torchilin and Trubetskoy, 1995;Mahapatro and Singh, 2011). Surface chemistry Analysis is determined by X-ray photoelectron spectroscopy (Mu and Feng, 2003;Si-Shen et al, 2004;Kim et al, 2005), Fourier transform infrared spectroscopy (Li et al, 2001;Choi and Kim, 2007;Yang et al, 2007) and Nuclear magnetic resonance spectroscopy (Li et al, 2001;Avgoustakis et al, 2002;Cheng et al, 2007;Dinarvand et al, 2011).…”

Section: 517 Plga-based Nanoparticles As Cancer Drug Delivery Systemsmentioning

confidence: 99%

See 2 more Smart Citations

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Mirakabad

Nejati-Koshki²,

Akbarzadeh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

406

154

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Section: Nanoparticle Characterization Techniquesmentioning

confidence: 99%

Section: Surface Modification Of Plga Nanoparticlesmentioning

confidence: 99%

Section: 517 Plga-based Nanoparticles As Cancer Drug Delivery Systemsmentioning

confidence: 99%

See 1 more Smart Citation

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Mirakabad

Nejati-Koshki²,

Akbarzadeh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

406

154

View full text Add to dashboard Cite

“…DPA can form a strong chelate chemical bond with the iron oxide surface, [23,24] and PEG has been used widely to protect nanoparticles for their stabilization under physiological conditions. [25,26] …”

Section: Introductionmentioning

confidence: 99%

Monodisperse Magnetite Nanoparticles Coupled with Nuclear Localization Signal Peptide for Cell‐Nucleus Targeting

Xie

Kohler

et al. 2008

Chemistry An Asian Journal

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Functionalization of monodisperse superparamagnetic magnetite (Fe 3 O 4 ) nanoparticles for cell specific targeting is crucial for cancer diagnostics and therapeutics. Targeted magnetic nanoparticles can be used to enhance the tissue contrast in magnetic resonance imaging (MRI), to improve the efficiency in anticancer drug delivery, and to eliminate tumor cells by magnetic fluid hyperthermia. Herein we report the nucleus-targeting Fe 3 O 4 nanoparticles functionalized with protein and nuclear localization signal (NLS) peptide. These NLS-coated nanoparticles were introduced into the HeLa cell cytoplasm and nucleus, where the particles were monodispersed and non-aggregated. The success of labeling was examined and identified by fluorescence microscopy and MRI. The work demonstrates that monodisperse magnetic nanoparticles can be readily functionalized and stabilized for potential diagnostic and therapeutic applications.

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“…Nanoparticles with a hydrophobic surface are rapidly taken up by the liver, spleen and lungs [13], while those with a hydrophilic surface showed an increased circulation time in the body [14]. Therefore, to achieve increased circulation time in the bloodstream and thus improved targeting, nanoparticles need to be 100M or less is size with a hydrophilic surface in order to reduce clearance by macrophages [15]. Paclitaxel nanoparticles have been shown to have similar efficacy, with faster administration times, when compared to conventional formulations in preclinical studies [16][17].…”

Section: Introductionmentioning

confidence: 99%

Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer

Najlah

Ahmed

Iqbal

et al. 2017

European Journal of Pharmaceutics and Biopharmaceutics

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Non-Small Cell Lung Cancer (NSCLC) is the most common type of lung cancer in both men and women. A recent phase IIb study demonstrated that disulfiram (DSF) in combination with cisplatin and vinorelbine was well tolerated and prolonged the survival of patients with newly diagnosed NSCLC. However, DSF is rapidly (4 minutes) metabolised in the bloodstream and it is this issue which is limiting its anticancer application in the clinic. We have recently demonstrated that a low dose of DSF-loaded PLGA nanoparticles supplemented with oral Cu inhibited tumour growth and reduced metastasis in a xenograft mouse lung cancer model. Here we demonstrate the influence of PLGA polymer, stabilizer loading and molecular weight as well as sonication time on the characteristics, including DSF release and the cytotoxicity of 10% w/w DSF-loaded PLGA nanoparticles. The paper demonstrates that the choice of PLGA as no significant influence on the characteristics of the nanoparticles apart from their DSF release, which is due to the differing degradation rates of the polymers. However, increasing the loading and molecular weight of the stabilizer as well as the sonication time reduced the size of the nanoparticles, reduced their ability to protect the DSF from reacting with Cu and degrading in serum, while increasing their DSF release rate and cytotoxicity. Additionally, increasing the sonication time resulted in the premature degradation of the PLGA, which increased the permeability of the nanoparticles further decreasing their ability to protect DSF from reacting with Cu and degrading in serum, while increasing their DSF release rate and cytotoxicity.

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Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system

Cited by 810 publications

References 77 publications

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Monodisperse Magnetite Nanoparticles Coupled with Nuclear Localization Signal Peptide for Cell‐Nucleus Targeting

Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer

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