Surface modification of poly(amidoamine) (PAMAM) dendrimer as antimicrobial agents

Abstract

Poly(amidoamine) (PAMAM) (G3) dendrimer was modified into quaternary ammonium salts using tertiary amines with different chain lengths: dimethyldodecyl amine, dimethylhexyl amine, and dimethylbutyl amine using an efficient synthetic route. The antimicrobial activity of these dendrimer ammonium salts against Staphylococcus and E-coli bacteria was examined using the disc diffusion method. It was found that quaternary ammonium salt prepared with the dimethyldodecyl amine exhibits antimicrobial efficacy against Staphalococus and E.coli bacteria.

Perspective: Dendrimer drugs for infection and inflammation

“…Escherichia coli) than Gram positive bacteria (e.g. Staphylococcus aureus) [45]. The molecular mechanism of action of this antimicrobial activity and cell surface toxicity is broadly based upon positively charged molecules punching holes in negatively charged bacterial and cell membranes to cause bacterial rupture and cell lysis respectively.…”

Synthesis of poly(2-hydroxyethyl methacrylate)-grafted poly(aminoamide) dendrimers as polymeric nanostructures

“…The absorption peaks at 2850 and 2930 cm −1 are contributed to the C-H stretching and C-H symmetric and asymmetric stretching of methyl groups [24]. Also, characteristic peaks at 3275 and 3450 cm −1 are attributed to the peripheral -NH 2 and amidic -NH groups, respectively [23], while peak at 3450 cm −1 may be related to the water absorbed on samples [25]. After conjugating RAFT agent, significant disappearance of peak at 3275 cm −1 related to peripheral amine groups confirms the amidation reaction.…”

“…1. 4.0GD dendrimer exhibits a strong peak at 1640 cm −1 related to stretching vibration of C=O groups of amide moieties in dendrimer structure [23]. The absorption peaks at 2850 and 2930 cm −1 are contributed to the C-H stretching and C-H symmetric and asymmetric stretching of methyl groups [24].…”

Nanocarriers Against Bacterial Biofilms

“…The polycationic structure of dendrimer biocides facilitates the initial electrostatic adsorption to negatively charged bacteria and increases membrane permeability, leading to complete disintegration of the bacterial membrane (Chen and Cooper, 2002). In particular, quaternary ammonium salt prepared with the dimethyldodecyl amine exhibited antimicrobial efficacy against Staphylococcus and E. coli bacteria (Charles et al, 2012).…”