Surface Modification of Polymeric Biomaterials

Güney, Aysun; Kara, Filiz; Özge, Özgen; Aksoy, Eda Ayşe; Hasırcı, Vasıf; Hasırcı, Nesrin

doi:10.1002/9783527649600.ch5

Cited by 12 publications

(9 citation statements)

References 269 publications

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“…5,6 Modification of biomaterial surfaces represents a promising route to engineer biofunctionality at material-blood interfaces enhancing the biocompatibility and antibacterial properties without altering the bulk property of biomaterials. 7,8 The traditional strategy for controlling biological responses by surface modification is through chemical [9][10][11][12][13][14] or physical [15][16][17] designs. One effective chemical approach is grafting, which places polymerized monomers or covalently couples existing polymer molecules onto the polymer surface.…”

Section: Introductionmentioning

confidence: 99%

Protein adsorption, platelet adhesion, and bacterial adhesion to polyethylene-glycol-textured polyurethane biomaterial surfaces

Siedlecki

2015

J. Biomed. Mater. Res.

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Traditional strategies for surface modification to enhance the biocompatibility of biomaterials often focus on a single route utilizing either chemical or physical approaches. This study combines the chemical and physical treatments as applied to poly(urethane urea) (PUU) biomaterials to enhance biocompatibility at the interface for inhibiting platelet-related thrombosis or bacterial adhesion-induced microbial infections. PUU films were first textured with submicron patterns by a soft lithography two-stage replication process, and then were grafted with polyethylene glycol (PEG). A series of biological response experiments including protein adsorption, platelet adhesion/activation, and bacterial adhesion/biofilm formation showed that PEG-grafted submicron textured biomaterial surfaces were resistant to protein adsorption, and greatly increased the efficiency in reducing both platelet adhesion/activation and bacterial adhesion/biofilm formation due to the additive effects of physical topography and grafted PEG. Results suggest that a combination of chemical modification and surface texturing will be more efficient in preventing biomaterial-associated thrombosis and infection of biomaterials. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 668-678, 2017.

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Section: Introductionmentioning

confidence: 99%

Protein adsorption, platelet adhesion, and bacterial adhesion to polyethylene-glycol-textured polyurethane biomaterial surfaces

Siedlecki

2015

J. Biomed. Mater. Res.

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“…e-PTFE membranes are often functionalized through covalent and non-covalent bonds, chemical impregnation, chemical surface modification, autologous vascularization, etc. These strategies are used to improve their properties and compatibility with blood tissue [ 12 , 13 ]. There are several commercially available e-PTFE covered stents for clinical use.…”

Section: Introductionmentioning

confidence: 99%

Expanded Polytetrafluoroethylene Membranes for Vascular Stent Coating: Manufacturing, Biomedical and Surgical Applications, Innovations and Case Reports

et al. 2023

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Coated stents are defined as innovative stents surrounded by a thin polymer membrane based on polytetrafluoroethylene (PTFE)useful in the treatment of numerous vascular pathologies. Endovascular methodology involves the use of such devices to restore blood flow in small-, medium- and large-calibre arteries, both centrally and peripherally. These membranes cross the stent struts and act as a physical barrier to block the growth of intimal tissue in the lumen, preventing so-called intimal hyperplasia and late stent thrombosis. PTFE for vascular applications is known as expanded polytetrafluoroethylene (e-PTFE) and it can be rolled up to form a thin multilayer membrane expandable by 4 to 5 times its original diameter. This membrane plays an important role in initiating the restenotic process because wrapped graft stent could be used as the treatment option for trauma devices during emergency situations and to treat a number of pathological vascular disease. In this review, we will investigate the multidisciplinary techniques used for the production of e-PTFE membranes, the advantages and disadvantages of their use, the innovations and the results in biomedical and surgery field when used to cover graft stents.

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“…Several surface functionalization methods can be used to modify the outermost layer of a material and to obtain a functional thin film on the material. 5,6 For instance, physical or chemical surface modification techniques such as the elaboration of self-assembled monolayers (SAMs) 7 or multilayered materials and 8−10 grafting of small molecules (silanes, isocyanates, etc.) 11,12 or polymers 13 are commonly reported.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Therefore, instead of changing the formulation and the bulk properties of the material, providing stimuli-responsive properties selectively to the surface of the material is an interesting alternative strategy for the development of smart materials. Several surface functionalization methods can be used to modify the outermost layer of a material and to obtain a functional thin film on the material. , For instance, physical or chemical surface modification techniques such as the elaboration of self-assembled monolayers (SAMs) or multilayered materials and − grafting of small molecules (silanes, isocyanates, etc. ) , or polymers are commonly reported.…”

Section: Introductionmentioning

confidence: 99%

Control of Interfacial Diels–Alder Reactivity by Tuning the Plasma Polymer Properties

et al. 2018

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Functionalizing the surface of a material with a smart plasma polymer coating is an interesting alternative strategy to obtain a thermoresponsive material without changing its formulation. On the basis of a low-pressure plasma polymerization process, the present work first aims to fabricate polymer thin films that react via the well-known thermoreversible Diels-Alder (DA) reaction (diene/dienophile cycloaddition). A two-step surface modification process based on (pulsed) plasma polymerization enables the design of functional coatings that contain furan (diene) groups. The reactivity of these surfaces with maleic anhydride (dienophile) in solution is thoroughly investigated, mainly by studying the kinetics of the DA reaction by advancing contact angle measurements. The determination of rate constants of reactions at various temperatures leads to the quantification of thermodynamic parameters such as the activation energy of the reaction as well as the enthalpy and entropy of activation related to the formation of the transition-state complex involved in the DA reaction. More interestingly, the design of furan-functionalized coatings with various physicochemical properties enables the understanding of the role played by the density of functional groups and the cross-linking rate of the polymer on the interfacial reactivity. Thus, we show in this work how to control the interfacial DA reaction on plasma coatings by tailoring the operating conditions of plasma polymerization.

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Surface Modification of Polymeric Biomaterials

Cited by 12 publications

References 269 publications

Protein adsorption, platelet adhesion, and bacterial adhesion to polyethylene-glycol-textured polyurethane biomaterial surfaces

Protein adsorption, platelet adhesion, and bacterial adhesion to polyethylene-glycol-textured polyurethane biomaterial surfaces

Expanded Polytetrafluoroethylene Membranes for Vascular Stent Coating: Manufacturing, Biomedical and Surgical Applications, Innovations and Case Reports

Control of Interfacial Diels–Alder Reactivity by Tuning the Plasma Polymer Properties

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