Surface modification of the biomedical polymer poly(ethylene terephthalate)

Abstract

X-ray photoelectron spectroscopy was used to characterize modified surfaces of a biomedically important polymer, poly(ethylene terephthalate). Several modification schemes were investigated and direct silanization with 3-aminopropyltriethoxysilane was found to be the optimum procedure, resulting in an aminated surface. Surface coverage of up to 100% was achieved with retention of the polymeric structural integrity. Further activation of the silanized surface was accomplished with two cross-linkers, glutaraldehyde and sebacoyl chloride. A simple biomolecule, L-cysteine, was successfully immobilized onto a surface pre-treated with 3-aminopropyltriethoxysilane and glutaraldehyde, with a coverage of 42%.

Facile Preparation of a Patterned, Aminated Polymer Surface by UV-Light-Induced Surface Aminolysis

“…This content, which indicates that a large number of amino groups have been introduced onto the surface, is encouraging for practical biomedical applications. [15] We believe that such a high nitrogen content could also provide an effective platform for the patterned immobilization of proteins, as proven by the experiments reported herein.…”

“…Using XPS, many authors [2,3,15,24] Wavenumber (cm -1 ) Figure 3. The ATR-FTIR spectra of an aminated PET surface formed by USAR: 1) virgin PET; 2) mass loss is 0.52 % (irradiation time was 180 s); 3) mass loss is 1.67 % (irradiation time was 360 s); and 4) DMF agent, purity is 99.8 % (UV intensity, 15 000 lWcm ±2 ; room temperature).…”

“…In contrast, on the aminated surface (Figs. 4e±h), the C(1s) peak can be deconvoluted into four distinct peaks with different assignments: 285.0 eV as aromatic carbon, 286.7 eV as carbon bearing a single oxygen (C±O), 287.8 eV as an amide-bonded carbon (OC±N), [15,25] and 288.9 eV as an ester-bonded carbon (COO). The existence of the amide-bonded carbon at 287.8 eV further implies that the ester bonds along PET chains may undergo aminolysis to form an amide bond.…”

“…This value is a little higher than the experimental value (6±7 %). As already noted, some degraded short PET chains containing nitrogen functionalities would be removed during the thorough washing after the reaction, [15] resulting in a lower nitrogen content on the aminated surface.…”

Surface characterization and cytocompatibility evaluation of silanized magnesium alloy AZ91 for biomedical applications

“…This process can easily modify properties such as absorption, electrical conduction, hydrophobicity/hydrophilicity of the surface [21], and in the same way it will influence cellular response. Silanization can be applied to a wide range of materials, especially polymeric [22] or ceramic materials [23]. In this study, we prepared different silane layers on the magnesium alloy AZ91.…”