Surface modification of titanium by hydrothermal treatment in Mg-containing solution and early osteoblast responses

Shi, Xiaohong; Nakagawa, Masaharu; Kawachi, Giichiro; Xu, Li; Ishikawa, Kunio

doi:10.1007/s10856-012-4596-4

Cited by 46 publications

(41 citation statements)

References 44 publications

(47 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…48 However, unlike the case of a fibroblast, a superhydrophilic surface favors the attachment of osteoblasts. 49 So the prepared samples with better wettability favor the formation of the tissue fragments and are easier to incorporate with the surrounding biological environment. 50 3.2.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

et al. 2016

ACS Appl. Mater. Interfaces

108

View full text Add to dashboard Cite

A nanostructured film composed of one-dimensional titanate nanowires (TNWs) was employed as a carrier of Ag nanoparticles and chitosan (CS) to improve the surface antibacterial activity and biocompatibility of titanium implants. A TNWs film was produced on a Ti substrate by an alkali hydrothermal reaction and subsequently doped by Ag nanoparticles through an ultraviolet light chemical reduction. The CS nanofilm was deposited on the Ag nanoparticles through a spin-assisted layer by layer assembly method. The results disclosed that Ag nanoparticles were successfully carried by TNWs and homogeneously distributed on the entire surface. Moreover, a CS nanofilm was also successfully deposited on the Ag nanoparticles. Antibacterial tests showed that the samples modified with a higher initial concentration of AgNO3 solution exhibited better antibacterial activity, and that a CS nanofilm could further improve the antibacterial activity of the TNWs. Cell viability and ALP tests revealed that the release of Ag(+) was detrimental for the growth, proliferation, and differentiation of MC3T3, and that CS could lower the negative effects of Ag gradually as the incubation time increased.

show abstract

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

et al. 2016

ACS Appl. Mater. Interfaces

108

View full text Add to dashboard Cite

show abstract

“…Incorporation of bioactive trace elements such as calcium, silicon, zinc, strontium, and magnesium is frequently used. [14][15][16][17][18] These trace elements are able to stimulate bone growth and bone healing by enhancing osteoblast activity. [19][20][21] As one of the most abundant elements in the human body, 22 magnesium is essential for bone metabolism and stimulates new bone formation, and may also interact with integrins of osteoblasts, which are responsible for cell adhesion and stability.…”

mentioning

confidence: 99%

Magnesium ion implantation on a micro/nanostructured titanium surface promotes its bioactivity and osteogenic differentiation function

Wang¹,

Li²,

Zhang³

et al. 2014

IJN

View full text Add to dashboard Cite

As one of the important ions associated with bone osseointegration, magnesium was incorporated into a micro/nanostructured titanium surface using a magnesium plasma immersion ion-implantation method. Hierarchical hybrid micro/nanostructured titanium surfaces followed by magnesium ion implantation for 30 minutes (Mg30) and hierarchical hybrid micro/nanostructured titanium surfaces followed by magnesium ion implantation for 60 minutes (Mg60) were used as test groups. The surface morphology, chemical properties, and amount of magnesium ions released were evaluated by field-emission scanning electron microscopy, energy dispersive X-ray spectroscopy, field-emission transmission electron microscopy, and inductively coupled plasma-optical emission spectrometry. Rat bone marrow mesenchymal stem cells (rBMMSCs) were used to evaluate cell responses, including proliferation, spreading, and osteogenic differentiation on the surface of the material or in their medium extraction. Greater increases in the spreading and proliferation ability of rBMMSCs were observed on the surfaces of magnesium-implanted micro/nanostructures compared with the control plates. Furthermore, the osteocalcin ( OCN ), osteopontin ( OPN ), and alkaline phosphatase ( ALP ) genes were upregulated on both surfaces and in their medium extractions. The enhanced cell responses were correlated with increasing concentrations of magnesium ions, indicating that the osteoblastic differentiation of rBMMSCs was stimulated through the magnesium ion function. The magnesium ion-implanted micro/nanostructured titanium surfaces could enhance the proliferation, spreading, and osteogenic differentiation activity of rBMMSCs, suggesting they have potential application in improving bone-titanium integration.

show abstract

“…Previous studies demonstrated similar results where cells on Mg containing surfaces showed higher proliferation and differentiation compared to Mg-free specimens. 30,38,39 Furthermore, Mg ions are considered to be beneficial for bone cell attachment. Zreiqat et al 23 reported that cells grown on Mg-modified alumina exhibited a significantly increased adhesion since binding of integrins to specific ligands depends on the presence of divalent cations.…”

Section: Discussionmentioning

confidence: 99%

Magnesium-containing mixed coatings on zirconia for dental implants: mechanical characterization and in vitro behavior

et al. 2015

View full text Add to dashboard Cite

An important challenge in the field of dental and orthopedic implantology is the preparation of implant coatings with bioactive functions that feature a high mechanical stability and at the same time mimic structural and compositional properties of native bone for a better bone ingrowth. This study investigates the influence of magnesium addition to zirconia-calcium phosphate coatings. The mixed coatings were prepared with varying additions of either magnesium oxide or magnesium fluoride to yttria-stabilized zirconia and hydroxyapatite. The coatings were deposited on zirconia discs and screw implants by wet powder spraying. Microstructure studies confirm a porous coating with similar roughness and firm adhesion not hampered by the coating composition. The coating morphology, mechanical flexural strength and calcium dissolution showed a magnesium content-dependent effect. Moreover, the in vitro results obtained with human osteoblasts reveal an improved biological performance caused by the presence of Mg 2þ ions. The magnesiumcontaining coatings exhibited better cell proliferation and differentiation in comparison to pure zirconia-calcium phosphate coatings. In conclusion, these results demonstrate that magnesium addition increases the bioactivity potential of zirconia-calcium phosphate coatings and is thus a highly suitable candidate for bone implant coatings.

show abstract

Surface modification of titanium by hydrothermal treatment in Mg-containing solution and early osteoblast responses

Cited by 46 publications

References 44 publications

Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

Antibacterial Activity of Silver Doped Titanate Nanowires on Ti Implants

Magnesium ion implantation on a micro/nanostructured titanium surface promotes its bioactivity and osteogenic differentiation function

Magnesium-containing mixed coatings on zirconia for dental implants: mechanical characterization and in vitro behavior

Contact Info

Product

Resources

About