Surface molecular imprinting on g-C3N4 photooxidative nanozyme for improved colorimetric biosensing

Wu, Yuanheng; Chen, Qiang; Liu, Shuang; Hua, Xing; Zhang, Menglin; Zhang, Xinfeng

doi:10.1016/j.cclet.2019.08.014

Cited by 68 publications

(27 citation statements)

References 34 publications

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“…For example, the catalytic activity of many nanozymes can be enhanced by light. [ 21,114,117,118 ] Control of sensors for imaging analytes in living cells is important for understanding the distribution and concentration fluctuation of analytes, allowing spatially and temporally controlled imaging.…”

Section: Discussionmentioning

confidence: 99%

Nanozyme‐based luminescence detection

Zhang

Liu

2020

Luminescence

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Nanozymes refer to nanomaterial‐based enzyme mimics. Most nanozyme assays use chromogenic molecules as substrates that can produce an absorbance change in the visible region upon reaction. For certain applications, such as imaging, fluorescence and luminescence signals are required. Fluorescence detection is also advantageous for sensor development due to its low background signal and high sensitivity. A few substrates, such as Amplex Red and luminol, allow luminescence generation with many oxidative nanozymes. In addition, these substrates can work at neutral pH, useful for intracellular applications. In this review, we summarize luminescence signalling‐based nanozyme systems. We begin with the properties of commonly used substrates. A few specific nanozymes are highlighted, including metal nanoparticles, metal oxide nanomaterials, carbon‐based nanomaterials, and metal–organic frameworks. Finally, a few future research opportunities are discussed.

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Section: Discussionmentioning

confidence: 99%

Nanozyme‐based luminescence detection

Zhang

Liu

2020

Luminescence

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“…Photooxidase mimics are activated by light for the oxidation of the substrate in the presence of dissolved oxygen [ 90 ]. Among the variety of nanomaterials that have been used as photooxidase mimics, the graphite carbon nitride (g-C 3 N 4 ) is an emerging visible-light-active organic semiconductor with intrinsic fluorescence properties.…”

Section: Nanozymes@mipsmentioning

confidence: 99%

“…Among the variety of nanomaterials that have been used as photooxidase mimics, the graphite carbon nitride (g-C 3 N 4 ) is an emerging visible-light-active organic semiconductor with intrinsic fluorescence properties. Hence, applications of g-C 3 N 4 in photocatalysis and photoluminescence-based biosensing are growing [ 90 ]. A recent study demonstrated the interesting properties of surface molecular imprinting on g-C 3 N 4 nanozymes for improved detection of L-cysteine in serum [ 90 ].…”

Section: Nanozymes@mipsmentioning

confidence: 99%

“…Hence, applications of g-C 3 N 4 in photocatalysis and photoluminescence-based biosensing are growing [ 90 ]. A recent study demonstrated the interesting properties of surface molecular imprinting on g-C 3 N 4 nanozymes for improved detection of L-cysteine in serum [ 90 ]. The enzymatic activity was first probed upon blue LED irradiation, leading to oxidation of the chromogenic substrate like TMB without destructive H 2 O 2 .…”

Section: Nanozymes@mipsmentioning

confidence: 99%

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Molecular Imprinting on Nanozymes for Sensing Applications

et al. 2021

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As part of the biomimetic enzyme field, nanomaterial-based artificial enzymes, or nanozymes, have been recognized as highly stable and low-cost alternatives to their natural counterparts. The discovery of enzyme-like activities in nanomaterials triggered a broad range of designs with various composition, size, and shape. An overview of the properties of nanozymes is given, including some examples of enzyme mimics for multiple biosensing approaches. The limitations of nanozymes regarding lack of selectivity and low catalytic efficiency may be surpassed by their easy surface modification, and it is possible to tune specific properties. From this perspective, molecularly imprinted polymers have been successfully combined with nanozymes as biomimetic receptors conferring selectivity and improving catalytic performance. Compelling works on constructing imprinted polymer layers on nanozymes to achieve enhanced catalytic efficiency and selective recognition, requisites for broad implementation in biosensing devices, are reviewed. Multimodal biomimetic enzyme-like biosensing platforms can offer additional advantages concerning responsiveness to different microenvironments and external stimuli. Ultimately, progress in biomimetic imprinted nanozymes may open new horizons in a wide range of biosensing applications.

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“…21 Meanwhile, g-C 3 N 4 was considered an excellent biosensor, due to its metal-free, high uorescence quantum yield, easy preparation, high stability as well as adequate biocompatibility. 22,23 For example, a g-C 3 N 4 single-layer quantum dot was introduced for uorescence imaging of the cellular nucleus. 24 Through hybridization with gold nanoparticles, the g-C 3 N 4 material was exploited as an electrochemiluminescence immunosensor.…”

Section: Introductionmentioning

confidence: 99%

Restricted binding of a model protein on C₃N₄nanosheets suggests an adequate biocompatibility of the nanomaterial

Pérez-Aguilar

Shao

2021

RSC Adv.

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Surface molecular imprinting on g-C3N4 photooxidative nanozyme for improved colorimetric biosensing

Cited by 68 publications

References 34 publications

Nanozyme‐based luminescence detection

Nanozyme‐based luminescence detection

Molecular Imprinting on Nanozymes for Sensing Applications

Restricted binding of a model protein on C₃N₄nanosheets suggests an adequate biocompatibility of the nanomaterial

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Surface molecular imprinting on g-C3N4 photooxidative nanozyme for improved colorimetric biosensing

Cited by 68 publications

References 34 publications

Nanozyme‐based luminescence detection

Nanozyme‐based luminescence detection

Molecular Imprinting on Nanozymes for Sensing Applications

Restricted binding of a model protein on C3N4nanosheets suggests an adequate biocompatibility of the nanomaterial

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Product

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Restricted binding of a model protein on C₃N₄nanosheets suggests an adequate biocompatibility of the nanomaterial