Surface Morphology and Properties of Bombyx mori Silk Fibroin Fiber Treated with I 2-KI Aqueous Solution

Khan, Md. Majibur Rahman; Gotoh, Yasuo; Morikawa, Hideaki; Miura, Mikihiko

doi:10.1177/0040517508095608

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…SEM was used to evaluate the alteration of the surface morphology of the SDI and SP samples. SP samples shows smooth surface morphology compared to the SDI which is consistent with earlier SEM studies of silk fibers as shown in Figure a, b . Surface roughing and flecks seen on the surface of SDI fibers might be due to the effect of DMDF-I 2 cross-linking.…”

Section: Results and Discussionsupporting

confidence: 89%

“…SP samples shows smooth surface morphology compared to the SDI which is consistent with earlier SEM studies of silk fibers as shown in Figure 5a, b. 46 Surface roughing and flecks seen on the surface of SDI fibers might be due to the effect of DMDF-I 2 cross-linking. EDX for SDI sample showed the atomic weight percentage of Iodine on the surface of fibers as 32.58 and in the core as 9.15 with respect to carbon and oxygen (Figure 5c).…”

Section: Resultssupporting

confidence: 89%

“…Prolonged cross-linking time led to the deterioration of the mechanical properties of the sample (data not shown). The tensile strength and elongation percentage of cross-linked silk suture are shown in Figure . , …”

Section: Results and Discussionmentioning

confidence: 99%

“…The tensile strength and elongation percentage of cross-linked silk suture are shown in Figure 4. 45,46 Scanning Electron Microscopy and EDX. SEM was used to evaluate the alteration of the surface morphology of the SDI and SP samples.…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

In Situ Iodination Cross-Linking of Silk for Radio-Opaque Antimicrobial Surgical Sutures

Francis

Pawar

Ghosh

et al. 2016

ACS Biomater. Sci. Eng.

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The purpose of the study is to develop a method of imparting radio-opacity to the silk fibers by stepwise 2,5-dimethoxy-2,5-dihydro-furan (DMDF)−iodine cross-linking reaction for suture fabrication with mechanical properties abiding with U.S. pharmacopeia guidelines along with non invasive imaging advantage in postoperative follow-up. Silk fibers isolated from Bombyx mori were cross-linked with suitable concentration of DMDF linked with iodine under elevated temperature and pressure. Cross-linked fibers knitted into sutures were subjected to further testing.Computed tomography (CT) images on day 28 of in vivo studies showed mean radioopacity value (MRV) of 213 ± 19.46 compared to the vertebral bone having value of 254.66 ± 0.51. Modified silk sutures demonstrated several advantages like high tensile strength (626 ± 23.3 MPa) and knot strength (388.6 ± 16.8 MPa) besides antimicrobial property. Encouraging preliminary in vitro and in vivo biocompatibility studies advocate the potential use of modified suture material in cardiac surgery, aneurysmal embolization surgeries, and arterio-venous occlusion surgeries.

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Section: Results and Discussionsupporting

confidence: 89%

Section: Resultssupporting

confidence: 89%

Section: Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

In Situ Iodination Cross-Linking of Silk for Radio-Opaque Antimicrobial Surgical Sutures

Francis

Pawar

Ghosh

et al. 2016

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…Collectively, these have aided in tissue healing and have altered the post-healing properties of the approximated tissue. [4,5] Sensing sutures integrated with ultra-thin electronic components have also been reported that have the ability to sense important parameters (e.g., heat, pH, and bacterial counts) related to wound healing or infection. [6] However, challenges still remain in the development of such advanced sutures.…”

Section: Doi: 101002/adma202004733mentioning

confidence: 99%

Biomimicking Antibacterial Opto‐Electro Sensing Sutures Made of Regenerated Silk Proteins

et al. 2020

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Surgical sutures play an important role across a wide range of medical treatments and a wide variety exist, differing in strength, size, composition, and performance. Recently, increasing interest has been paid to bioactive and electronic sutures made of synthetic polymers, owing to their ability to reduce inflammation as well as medically and/or electronically facilitate wound healing. However, integrating sensing capabilities into bioactive sutures without adversely affecting their mechanical strength, biocompatibility, and/or bioactivity remains challenging. In this work, a set of biomimicking, antibacterial, and sensing sutures based on the regenerated silk fibroin is designed and fabricated. These sensing sutures, inspired by the “core–shell” multilayered structure of natural spider‐silk fibers, are hierarchically structured and heterogeneously functionalized to allow for the integration of multiple, clinically favorable functions into one suture device. These functions included: reducing inflammation and bacterial infection in wound sites, measuring tension of both the tissue and suture, and aiding tissue healing via multi‐modal controlled drug and growth factor release. Critically, these functions are coupled with real‐time optical and electronic monitoring capabilities. This approach provides greater insight into multifunctional sutures with inherent sensing capabilities and offers enormous potential in both therapeutic and diagnostic applications.

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Silk‐Based Biomaterials in Biomedical Textiles and Fiber‐Based Implants

Chen

et al. 2015

Adv Healthcare Materials

157

112

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Biomedical textiles and fiber-based implants (BTFIs) have been in routine clinical use to facilitate healing for nearly five decades. Amongst the variety of biomaterials used, silk-based biomaterials (SBBs) have been widely used clinically viz. sutures for centuries and are being increasingly recognized as a prospective material for biomedical textiles. The ease of processing, controllable degradability, remarkable mechanical properties and biocompatibility have prompted the use of SBBs for various BTFIs for extracorporeal implants, soft tissue repair, healthcare/hygiene products and related needs. The present review focuses on BTFIs from the perspective of types and physical and biological properties, and this discussion is followed with an examination of the advantages and limitations of BTFIs from SBBs. The review covers progress in surface coatings, physical and chemical modifications of SBBs for BTFIs and identifies future needs and opportunities for the further development for BTFIs using SBBs.

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Surface Morphology and Properties of Bombyx mori Silk Fibroin Fiber Treated with I 2-KI Aqueous Solution

Cited by 8 publications

References 24 publications

In Situ Iodination Cross-Linking of Silk for Radio-Opaque Antimicrobial Surgical Sutures

In Situ Iodination Cross-Linking of Silk for Radio-Opaque Antimicrobial Surgical Sutures

Biomimicking Antibacterial Opto‐Electro Sensing Sutures Made of Regenerated Silk Proteins

Silk‐Based Biomaterials in Biomedical Textiles and Fiber‐Based Implants

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