Surface morphology of spin‐coated molecularly imprinted polymer films

Campbell, Sara E.; Collins, Mary; Xie, Lei; BelBruno, Joseph J.

doi:10.1002/sia.3030

Cited by 17 publications

(12 citation statements)

References 35 publications

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“…Removal of the nicotine from the MIP results in a loss of the stripe morphology and the observation of a number of pores in the surface, Figure 3(b). The pores are apparently formed during the solidification process of the polymer films and are caused by the presence of the template molecules and the porogen solvent during the film growth process 12. The assumption is that the pores are present in the “as produced” samples but lie beneath the stripe morphology.…”

Section: Resultsmentioning

confidence: 99%

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Characterization of functional states in nicotine‐ and cotinine‐imprinted poly(4‐vinylphenol) films by nanoindentation

Richter

BelBruno

2011

J of Applied Polymer Sci

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Thin, imprinted poly(4-vinylphenol) (PVP) films were produced by spin coating using nicotine or its metabolite, cotinine, as template molecules. The template molecules were extracted from these films and later reloaded (or cross-loaded) from solution. Depth sensing nanoindentation was applied to measure the nanomechanical properties of the imprinted polymer films. Changes in the nanomechanical properties were correlated to the functional state of the imprinted polymer, allowing identification of the films in their ''as produced'' state, ''template removed state or ''reloaded'' state. In addition, the nanomechanical properties were capable of identifying which of the two template molecules were inserted in to a film. Reinsertion of a template molecule into a ''template removed'' film was found to increase the nanohardness over the values recorded for the ''as produced'' film. This behavior was discussed in terms of the hydrogen bonding characteristics of the materials (through density functional calculations) and the physical properties of poly(4-vinylphenol) coatings.

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Section: Resultsmentioning

confidence: 99%

“…A template‐host network is allowed to form in solution and precipitated by immersion in a nonsolvent. Originally developed to produce MIP membranes, we have adapted this procedure to the production of thin, 300 nm to 5 μm, films via spin coating10–12 and hydrogen bond interactions between the template and host polymer.…”

Section: Introductionmentioning

confidence: 99%

Characterization of functional states in nicotine‐ and cotinine‐imprinted poly(4‐vinylphenol) films by nanoindentation

Richter

BelBruno

2011

J of Applied Polymer Sci

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“…In organic solvents, hydrogen bonding explains most of the energetic differences between the template of interest and various functional monomers (Dong et al, 2005;Campbell et al, 2009;Dong et al, 2009;Kowalska et al, 2009;Riahi et al, 2009), as well as the preference for template/functional monomer complex compared with that of a structural analogue of the template (Riahi et al, 2009). Dipolar interactions may also contribute (Riahi et al, 2009).…”

Section: Prepolymerization Complex Studiesmentioning

confidence: 99%

A brief review of coarse‐grained and other computational studies of molecularly imprinted polymers

Levi

Raim

Srebnik

2011

J of Molecular Recognition

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Molecular imprinting is an established method for the creation of artificial recognition sites in synthetic materials through polymerization and cross-linking in the presence of template molecules. Removal of the templates leaves cavities that are complementary to the template molecules in size, shape, and functionality. In recent years, various theoretical and computational models have been developed as tools to aid in the design of molecularly imprinted polymers (MIPs) or to provide insight into the features that determine MIP performance. These studies can be grouped into two general approaches-screening for possible functional monomers for particular templates and macromolecular models focusing on the structural characterization of the imprinted material. In this review, we pay special attention to coarse-grained models that characterize the functional heterogeneity in imprinted pores, but also cover recent advances in atomistic and first principle studies. We offer a critical assessment of the potential impact of the various models towards improving the state-of-the-art of molecular imprinting.

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“…MIPs are preferred in thin films form than particles form in application of biosensors. Moreover, surface morphology of MIP films have been studied at the micro scale by several groups (Spivak et al 2004;Richter et al 2006;González et al 2006;BelBruno et al 2007;Campbell et al 2009;Vendamme et al 2009). However, specificity in morphology on imprinted nanocavities on a molecular scale has not been discussed in previous studies.…”

Section: Introductionmentioning

confidence: 99%

Enhanced anesthetic propofol biochips by modifying molecularly imprinted nanocavities of biosensors

Hong

Lin

Hong

et al. 2012

Biomed Microdevices

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This paper presents enhanced performance of anesthetic propofol biosensors by modifying molecularly imprinted nanocavities of biosensors. In this work, the relationship between molecularly imprinted nanocavities and performance of molecularly imprinted polymer (MIP) films is investigated. The morphological control of imprinted nanocavities on molecularly imprinted biosensors is done by adjusting polymer composition and polymerization process. The newly developed MIP biosensors are characterized using our developed microfluidic biochips and optical microsystems. Experimental results show that the sizes of molecularly imprinted nanocavities were reduced to 10 to 14 nm from 10 to 25 nm. The roughness of the MIP film surface was reduced to 2.5 nm from 6.6 nm. Smaller imprinted nanocavities have better molecular separation performance. The specificity and linearity of the anesthetic biosensors could be enhanced by adjusting morphology of imprinted nanocavities. The linearity and the sensitivity of the microfluidic biochip with an improved on-chip MIP biosensor have been enhanced from 0.9341 to 49.5 mV/mm².ml/μg, respectively, to 0.9782 and 176.9 mV/mm².ml/μg. The anesthetic propofol biosensor presented in this study is applicable to numerous fluidic-based disposable biochips.

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Surface morphology of spin‐coated molecularly imprinted polymer films

Cited by 17 publications

References 35 publications

Characterization of functional states in nicotine‐ and cotinine‐imprinted poly(4‐vinylphenol) films by nanoindentation

Characterization of functional states in nicotine‐ and cotinine‐imprinted poly(4‐vinylphenol) films by nanoindentation

A brief review of coarse‐grained and other computational studies of molecularly imprinted polymers

Enhanced anesthetic propofol biochips by modifying molecularly imprinted nanocavities of biosensors

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