Surface phosphonation treatment shows dose-dependent enhancement of the bioactivity of polyetheretherketone

Liu, Lvhua; Zhang, Qianyu; Yu, Lin; Hu, Ziliang; Liu, Ying

doi:10.1039/c9ra05229a

Cited by 18 publications

(9 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phosphonation is the introduction of a phosphate group on the surface of a biomaterial. Various methods, such as diazonium chemistry and polymerization of Vinyl phosphonic acid, have been used to graft the functional group on the surface of PEEK, which has increased cell adhesion, spreading, proliferation, and differentiation in vitro and the bone–implant contact ratio in vivo [ 66 , 67 , 68 ], as shown in Table 5 . It serves as an optimal surface treatment, but the compatibility of phosphonation with other treatments will have to be assessed.…”

Section: Surface Treatmentsmentioning

confidence: 99%

Surface Treatments of PEEK for Osseointegration to Bone

2023

View full text Add to dashboard Cite

Polymers, in general, and Poly (Ether-Ether-Ketone) (PEEK) have emerged as potential alternatives to conventional osseous implant biomaterials. Due to its distinct advantages over metallic implants, PEEK has been gaining increasing attention as a prime candidate for orthopaedic and dental implants. However, PEEK has a highly hydrophobic and bioinert surface that attenuates the differentiation and proliferation of osteoblasts and leads to implant failure. Several improvements have been made to the osseointegration potential of PEEK, which can be classified into three main categories: (1) surface functionalization with bioactive agents by physical or chemical means; (2) incorporation of bioactive materials either as surface coatings or as composites; and (3) construction of three-dimensionally porous structures on its surfaces. The physical treatments, such as plasma treatments of various elements, accelerated neutron beams, or conventional techniques like sandblasting and laser or ultraviolet radiation, change the micro-geometry of the implant surface. The chemical treatments change the surface composition of PEEK and should be titrated at the time of exposure. The implant surface can be incorporated with a bioactive material that should be selected following the desired use, loading condition, and antimicrobial load around the implant. For optimal results, a combination of the methods above is utilized to compensate for the limitations of individual methods. This review summarizes these methods and their combinations for optimizing the surface of PEEK for utilization as an implanted biomaterial.

show abstract

Section: Surface Treatmentsmentioning

confidence: 99%

Surface Treatments of PEEK for Osseointegration to Bone

2023

View full text Add to dashboard Cite

show abstract

“…More recently Zheng et al [31] applied single-step ultraviolet-initiated graft polymerization for introduction of sulfonate groups onto the PEEK surface. The use of vinylsulfonic acid sodium (VSA) and vinylphosphonic acid (VPA) to improve the bioactivity of the treated PEEK surface opened a new modification path intensively applied in the latest research [31][32][33]. In vitro studies using the MC3T3-E1 line of osteoblasts showed that initial adhesion, spreading, proliferation, and osteogenic differentiation were greatly improved after PEEK surface modification.…”

Section: Photo-induced Polymerization For Surface Modification Of Peekmentioning

confidence: 99%

Surface Modifications of Poly(Ether Ether Ketone) via Polymerization Methods—Current Status and Future Prospects

Flejszar

Chmielarz

2020

Materials

View full text Add to dashboard Cite

Surface modification of poly(ether ether ketone) (PEEK) aimed at applying it as a bone implant material aroused the unflagging interest of the research community. In view of the development of implantology and the growing demand for new biomaterials, increasing biocompatibility and improving osseointegration are becoming the primary goals of PEEK surface modifications. The main aim of this review is to summarize the use of polymerization methods and various monomers applied for surface modification of PEEK to increase its bioactivity, which is a critical factor for successful applications of biomedical materials. In addition, the future directions of PEEK surface modifications are suggested, pointing to low-ppm surface-initiated atom transfer radical polymerization (SI-ATRP) as a method with unexplored capacity for flat surface modifications.

show abstract

“…Since the end goal of osseointegration is the binding of bone to the implant surface, many surface modifications have simply improved the attachment and mineralization of bone-forming cells. Previous work has shown that simultaneously increasing the roughness of PEEK implants , and changing the surface chemistry − can improve the osseointegration of PEEK implants by enhancing the mineralization and osteogenic differentiation of MSCs. , However, the role of the immune response in these improvements was not evaluated and the mechanism underlying the improvements is not yet fully understood.…”

Section: Introductionmentioning

confidence: 99%

The Role of Surface Chemistry in the Osseointegration of PEEK Implants

Buck

Lee

Gao

et al. 2022

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Poly(etheretherketone) (PEEK) implants suffer from poor osseointegration because of chronic inflammation. In this study, we hypothesized that adding NH 2 and COOH groups to the surface of PEEK could modulate macrophage responses by altering protein adsorption and improve its osseointegration. NH 2 and COOHfunctionalized PEEK surfaces induced pro-and anti-inflammatory macrophage responses, respectively, and differences in protein adsorption patterns on these surfaces were related to the varied inflammatory responses. The macrophage responses to NH 2 surfaces significantly reduced the osteogenic differentiation of mesenchymal stem cells (MSCs). MSCs cultured on NH 2 surfaces differentiated less than those on COOH surfaces even though NH 2 surfaces promoted the most mineralization in simulated body fluid solutions. After 14 days in rat tibia unicortical defects, the bone around NH 2 surfaces had thinner trabeculae and higher specific bone surface than the bone around unmodified implants; surprisingly, the NH 2 implants significantly increased bone-binding over the unmodified implants, while COOH implants only showed a trend for increasing bone-binding. Taken together, these results suggest that both mineral-binding and immune responses play a role in osseointegration, and PEEK implant integration may be improved with mixtures of these two functional groups to harness the ability to reduce inflammation and bind bone strongly.

show abstract

Surface phosphonation treatment shows dose-dependent enhancement of the bioactivity of polyetheretherketone

Abstract: Polyetheretherketone (PEEK) is a promising alternative for biomedical metallic implants in orthopedic and dental applications because its elastic modulus is similar to that of bone.

Cited by 18 publications

References 52 publications

Surface Treatments of PEEK for Osseointegration to Bone

Surface Treatments of PEEK for Osseointegration to Bone

Surface Modifications of Poly(Ether Ether Ketone) via Polymerization Methods—Current Status and Future Prospects

The Role of Surface Chemistry in the Osseointegration of PEEK Implants

Contact Info

Product

Resources

About