Surface plasmon resonance biosensors for highly sensitive detection in real samples

Sepúlveda, Borja; Carrascosa, Laura G.; Regatos, David; Otte, Marinus A.; Fariña, David; Lechuga, Laura M.

doi:10.1117/12.827062

Cited by 14 publications

(5 citation statements)

References 28 publications

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“…Label-free biosensors are devices capable of quantitative assay of target analyte in a sample without using labels such as fluorophores and radioactive isotopes that need to be prelabeled on capture probes as in label-aided assays. − The label-free devices that could allow real-time monitoring of time-dependent binding kinetics as well as the time-efficient and cost-effective sensing operation has led to development of a variety of technologies for clinical diagnosis of diseases, ranging from those by cyclic voltammetry techniques, − impedance spectroscopy, , optical absorption spectroscopy, , and methods based on optical refractometry. − …”

Section: Introductionmentioning

confidence: 99%

Label-Free Optical Biochemical Sensors via Liquid-Cladding-Induced Modulation of Waveguide Modes

Tran¹,

Kim²,

Phan³

et al. 2017

ACS Appl. Mater. Interfaces

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We demonstrated modulation of the waveguide mode mismatch via liquid cladding of the controllable refractive index for label-free quantitative detection of concentration of chemical or biological substances. A multimode optical fiber with its core exposed was used as the sensor head with the suitable chemical modification of its surface. Injected analyte liquid itself formed the liquid cladding for the waveguide. We found that modulation of the concentration of analyte injected enables a degree of the waveguide mode mismatch to be controlled, resulting in sensitive change in optical power transmission, which was utilized for its real-time quantitative assay. We applied the device to quantitating concentration of glycerol and bovine serum albumin (BSA) solutions. We obtained experimentally the limit of detection (LOD) of glycerol concentration, 0.001% (volume ratio), corresponding to the resolvable index resolution of ∼1.02 × 10 RIU (refractive index unit). The presented sensors also exhibited reasonably good reproducibility. In BSA detection, the sensor device response was sensitive to change in the refractive indices not only of liquid bulk but also of layers just above the sensing surface with higher sensitivity, providing the LOD experimentally as ∼3.7 ng/mL (mass coverage of ∼30 pg/mm). A theoretical model was also presented to invoke both mode mismatch modulation and evanescent field absorption for understanding of the transmission change, offering a theoretical background for designing the sensor head structure for a given analyte. Interestingly, the device sensing length played little role in the important sensor characteristics such as sensitivity, unlike most of the waveguide-based sensors. This unraveled the possibility of realizing a highly simple structured label-free sensor for point-of-care testing in a real-time manner via an optical waveguide with liquid cladding. This required neither metal nor dielectric coating but still produced sensitivity comparable to those of other types of label-free sensors such as plasmonic fiber ones.

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Section: Introductionmentioning

confidence: 99%

Label-Free Optical Biochemical Sensors via Liquid-Cladding-Induced Modulation of Waveguide Modes

Tran¹,

Kim²,

Phan³

et al. 2017

ACS Appl. Mater. Interfaces

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“…An external magnetic field of 4 kOe was applied normal to the film plane. The magnetic activity of SPP was evaluated on the basis of the normalized reflectivity change using the following formula: 10,26,27) Ni, Co, and Zn) films were analyzed by X-ray diffraction (XRD) with Cu Kα radiation. The magnetic properties of the films were measured using a vibrating sample magnetometer (VSM) under the magnetic field H of ±10 kOe applied normal to the film plane.…”

Section: Experimental Methodsmentioning

confidence: 99%

Magnetic activity of surface plasmon resonance using dielectric magnetic materials fabricated on quartz glass substrate

Narushima

Ashizawa

Brachwitz

et al. 2016

Jpn. J. Appl. Phys.

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The magnetic activity of surface plasmons in Au/MFe2O4 (M = Ni, Co, and Zn) polycrystalline bilayer films fabricated on a quartz glass substrate was studied for future magnetic sensor applications using surface plasmon resonance. The excitation of surface plasmons and their magnetic activity were observed in all investigated Au/MFe2O4 films. The magnetic activity of surface plasmons of the polycrystalline Au/NiFe2O4 film was larger than those of the other polycrystalline Au/MFe2O4 films, the epitaxial NiFe2O4 film, and metallic films. The large magnetic activity of surface plasmons of the polycrystalline film is controlled by manipulating surface plasmon excitation conditions and magnetic properties.

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“…[132][133][134] The approach accounts for the local-field effects, and thus allows for estimating correctly the influence of the system shape and dimensions on its MO response. In addition to the localized surface plasmon characteristic of nano-objects, propagating SPPs are of great application relevance 135 in spectroscopy, 136 microscopy, 137 and sensorics, [138][139][140] to name a few.…”

Section: Magneto-optical Propertiesmentioning

confidence: 99%

Multifunctional Magnetoplasmonic Nanomaterials and Their Biomedical Applications

Zhou¹,

Zou²,

Koh³

et al. 2014

j biomed nanotechnol

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Multifunctional magnetoplasmonic (Au-Fe x O y ) nanomaterials are characterized by some features of iron oxide and gold, such as surface chemistry, special optical properties, and superparamagnetic properties, which have helped to draw much attention to their biomedical applications. In this review, the state of the art of this rapidly developing field is described. We review the developments in different approaches to integrating the magnetic and plasmonic properties in a single nanoparticle with different morphological traits. Specific plasmonic and magneto-optical properties of magnetoplasmonic nanoparticles are explained; this information should shed light on the future development of multifunctional magnetoplasmonic nanomaterials. We also review cytotoxicity of magnetoplasmonic nanoparticles by in vitro and in vivo studies. With the multifunctional properties of magnetoplasmonic nanomaterials, a variety of applications such as biosensor, bioseparation, multimodal imaging, and therapeutics is possible and is highlighted here, in addition to outlining the future trends and perspectives of these sophisticated nanocomposites.

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Surface plasmon resonance biosensors for highly sensitive detection in real samples

Cited by 14 publications

References 28 publications

Label-Free Optical Biochemical Sensors via Liquid-Cladding-Induced Modulation of Waveguide Modes

Label-Free Optical Biochemical Sensors via Liquid-Cladding-Induced Modulation of Waveguide Modes

Magnetic activity of surface plasmon resonance using dielectric magnetic materials fabricated on quartz glass substrate

Multifunctional Magnetoplasmonic Nanomaterials and Their Biomedical Applications

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