Surface plasmon resonance in monitoring of complement activation on biomaterials

Arima, Yusuke; Toda, Mitsuaki; Iwata, Hiroo

doi:10.1016/j.addr.2011.06.018

Cited by 30 publications

(28 citation statements)

References 103 publications

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“…Further biological context-relevant assays have been employed to confirm and to investigate such interaction in a more quantitative way. well as protein-carbohydrates, without any molecular labeling, such as fluorescent labeling and radiolabelling (103).…”

mentioning

confidence: 99%

Structural Basis for Interactions of thePhytophthora sojaeRxLR Effector Avh5 with Phosphatidylinositol 3-Phosphate and for Host Cell Entry

Sun¹,

Kale²,

Azurmendi³

et al. 2013

MPMI

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Oomycetes, such as Phytophthora sojae, are plant pathogens that employ protein effectors that enter host cells to facilitate infection. Plants may overcome infection by recognizing pathogen effectors via intracellular receptors (R proteins) that form part of their defense system. Entry of some effector proteins into plant cells is mediated by conserved RxLR motifs in the effectors and phosphoinositides (PIPs) resident in the host plasma membrane such as phosphatidylinositol 3-phosphate (PtdIns(3)P). Recent reports differ regarding the regions on RxLR effector proteins involved in PIP recognition. To clarify these differences, I have structurally and functionally characterized the P. sojae effector, avirulence homolog-5 (Avh5).

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mentioning

confidence: 99%

Structural Basis for Interactions of thePhytophthora sojaeRxLR Effector Avh5 with Phosphatidylinositol 3-Phosphate and for Host Cell Entry

Sun¹,

Kale²,

Azurmendi³

et al. 2013

MPMI

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“…An important example is provided by the study of complement activation in controlled experimental conditions. SPR has been used to monitor the activation of the complement system of proteins, either for biomedical studies [32] or to guide the development of biomaterials [33].…”

Section: The Challenge Of Complex Matricesmentioning

confidence: 99%

Emerging applications of label-free optical biosensors

et al. 2017

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Abstract:Innovative technical solutions to realize optical biosensors with improved performance are continuously proposed. Progress in material fabrication enables developing novel substrates with enhanced optical responses. At the same time, the increased spectrum of available biomolecular tools, ranging from highly specific receptors to engineered bioconjugated polymers, facilitates the preparation of sensing surfaces with controlled functionality. What remains often unclear is to which extent this continuous innovation provides effective breakthroughs for specific applications. In this review, we address this challenging question for the class of label-free optical biosensors, which can provide a direct signal upon molecular binding without using secondary probes. Label-free biosensors have become a consolidated approach for the characterization and screening of molecular interactions in research laboratories. However, in the last decade, several examples of other applications with high potential impact have been proposed. We review the recent advances in label-free optical biosensing technology by focusing on the potential competitive advantage provided in selected emerging applications, grouped on the basis of the target type. In particular, direct and real-time detection allows the development of simpler, compact, and rapid analytical methods for different kinds of targets, from proteins to DNA and viruses. The lack of secondary interactions facilitates the binding of small-molecule targets and minimizes the perturbation in single-molecule detection. Moreover, the intrinsic versatility of label-free sensing makes it an ideal platform to be integrated with biomolecular machinery with innovative functionality, as in case of the molecular tools provided by DNA nanotechnology.

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“…One particular merit of SPR technique is its ability to monitor the change at surfaces in a liquid environment in real time, thus allowing for the investigation of dynamic process. SPR has proved to be very useful for biomolecule interaction analysis (BIA) during the past two decades and its applications in biomedical and life science are summarized in several recent reviews . SPR instruments can be divided into four categories: (i) angular modulated SPR; (ii) wavelength modulated SPR; (iii) intensity modulated SPR; (iv) phase modulated SPR.…”

Section: Fundamental Principlesmentioning

confidence: 99%

Surface Plasmon‐Based Techniques for the Analysis of Plasma Deposited Functional Films and Surfaces

Chu

Zhang

Förch

2015

Plasma Processes & Polymers

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Herein we demonstrate that two surface plasmon-based techniques (i.e., SPR and OWS) allow for sensitive and real-time monitoring of plasma polymers of different thicknesses ranging from several nanometers to micrometers. Firstly, the fundamentals and the implementation of SPR/OWS are given. Examples about the use of SPR and OWS for the characterization of plasma deposited thin films are then presented, with emphasis on the stability and the swelling of those films in humid atmospheres and in aqueous media. The binding behavior of biological species (e.g., nucleic acid, protein, etc.) onto plasma polymer surfaces as seen by SPR and OWS are also discussed. The results clearly show that surface plasmon optics will play an essential part in the understanding and the future development of plasma deposited polymers. 0 200 400 600 800 1000 28 30 32 34 36 38 40 42 Reflectivity / % Time / min after extraction as deposited ppAA, 100W, CW, 0,1mbar

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Surface plasmon resonance in monitoring of complement activation on biomaterials

Cited by 30 publications

References 103 publications

Structural Basis for Interactions of thePhytophthora sojaeRxLR Effector Avh5 with Phosphatidylinositol 3-Phosphate and for Host Cell Entry

Structural Basis for Interactions of thePhytophthora sojaeRxLR Effector Avh5 with Phosphatidylinositol 3-Phosphate and for Host Cell Entry

Emerging applications of label-free optical biosensors

Surface Plasmon‐Based Techniques for the Analysis of Plasma Deposited Functional Films and Surfaces

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