Surface Polysaccharide from
            <i>Staphylococcus aureus</i>
            M That Contains Taurine,
            <scp>d</scp>
            -Aminogalacturonic Acid, and
            <scp>d</scp>
            -Fucosamine

Liau, Deng-Fong; Melly, M. Ann; Hash, John H.

doi:10.1128/jb.119.3.913-922.1974

Cited by 42 publications

(23 citation statements)

References 29 publications

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“…However, our title indicates that our investigation was limited to unencapsulated strains. Liau et al (14) found that their strain M of S. aureus contained taurine, D-aminogalacturonic acid, and r-fucosamine. In our unencapsulated strains we detected only a trace of Lufucose.…”

Section: Resultsmentioning

confidence: 99%

Relationship of capsular type to biochemical and immunological properties of teichoic acid preparations from unencapsulated strains of Staphylococcus aureus

Ohtomo¹,

Yoshida²,

Clemente³

1976

Infect Immun

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We investigated the biochemical and immunological characteristics of teichoic acid preparations (TAP) obtained from four unencapsulated strains ofStaphylococcus aureus which nonetheless, according to the serum-soft agar technique, produced capsular type antigen and were representative of the four types A, B, C, and D. In the agar diffusion test, TAP of each strain produced a single precipitin line only against rabbit antisera corresponding to the homologous capsular type; no lines were observed against antisera to the heterologous capsular type. All TAP were ribitol type except one, glycerol, prepared from a capsular type D strain. Major acetylglucosaminyl residues of TAP from strains having capsular type A and C antigens were attached to the polyribitol phosphate by 8-linkage, whereas TAP from a type B antigen strain had an alinkage; type D antigen was attached to the polyglycerol phosphate by the /8linkage. Chemical analyses and infrared spectrograms of these TAP further confirmed their heterogeneous nature. Yoshida (26,27) reported four serologically different capsular type strains of Staphylococcus aureus by the serum-soft agar technique and designated them as capsular types A, B, C, and D. By modifying the pH of the serum-soft agar from 7.2 to 6.0, Yoshida et al. (29) detected capsular type antigen in unencapsulated strains of S. aureus. Because biochemical and immunological heterogeneity of teichoic acid preparations (TAP) among strains of S. aureus pose certain problems, attempts were therefore made to investigate the relationship of the biological and immunological properties of TAP to the capsular antigen of unencapsulated strains ofS. aureus. In this paper we report the results of this investigation. MATERIALS AND METHODSStrains. Strains A-28, B-62, C-25, and D-68 of S. aureus were used. These were positive for coagulase, deoxyribonuclease, mannitol fermentation, acid phosphatase, and clumping-factor reaction (30). They were compact in the serum-soft agar of Finkelstein and Sulkin (10), and their capsular type (29) corresponds to the capital letter in the strain designation.Medium. Strains were cultured at 370C for 20 h in 'Journal article no. 7807 from the Michigan Agricultural Experiment Station.

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Section: Resultsmentioning

confidence: 99%

Relationship of capsular type to biochemical and immunological properties of teichoic acid preparations from unencapsulated strains of Staphylococcus aureus

Ohtomo¹,

Yoshida²,

Clemente³

1976

Infect Immun

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“…Incorporation into polysaccharides produces a negatively charged capsule surface. Antigenic polysaccharides consist of taurine, D-fucosamine, and D-aminogalacturonate from which taurine can be released by mild hydrolysis (455).…”

Section: Other Taurine Metabolitesmentioning

confidence: 99%

Physiological actions of taurine

Huxtable

1992

Physiological Reviews

2,405

1,625

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TABLE 1. Some biological actions of taurine Action References Action References Cardiovascular system Antiarrhythmic Positive inotropy at low calcium Negative inotropy at high calcium Potentiation of digitalis inotropy Antagonism of calcium paradox Hypotensive (central and peripheral action) Retardation of lesion development in calcium overload cardiomyopathy Increased resistance of platelets to aggregation

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“…Aminouronic acids are uncommon among the CPS of pathogens (20). The CPS of Salmonella typhi (Vi) and of Staphylococcus aureus, however, contain aminouronic acids (12,16,23,48). Since we were interested also in synthesizing conjugates with the CPS of invasive S. aureus, which are difficult to obtain in high yield, we used Pn12F as a model.…”

mentioning

confidence: 99%

Synthesis and physicochemical and immunological characterization of pneumococcus type 12F polysaccharide-diphtheria toxoid conjugates

et al. 1988

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Surface Polysaccharide from Staphylococcus aureus M That Contains Taurine, d -Aminogalacturonic Acid, and d -Fucosamine

Cited by 42 publications

References 29 publications

Relationship of capsular type to biochemical and immunological properties of teichoic acid preparations from unencapsulated strains of Staphylococcus aureus

Relationship of capsular type to biochemical and immunological properties of teichoic acid preparations from unencapsulated strains of Staphylococcus aureus

Physiological actions of taurine

Synthesis and physicochemical and immunological characterization of pneumococcus type 12F polysaccharide-diphtheria toxoid conjugates

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