Surface properties and biocompatibility of A-B-A type block copolymer membranes consisting of poly(γ-benzyl-l-glutamate) as the A component and polyisoprene as the B component

Yoda, Ryuichiro; Komatsuzaki, Shigeru; Hayashi, Toshio

doi:10.1016/0142-9612(95)98125-x

Cited by 19 publications

(10 citation statements)

References 13 publications

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“…[141,142] Biocompatibility was investigated for poly(c-benzyl glutamate)-block-polyisoprene-block-poly(c-benzyl glutamate) triblock copolymer membranes. [143] Surface coating of a PAN hollow fibre membrane by a poly(methoxy poly(ethylene oxide) methacrylate)-block-poly(methyl methacrylate), which is a hydrophilic-hydrophobic block copolymer, lead to an increase of wettability and reduced the adhesion of platelets in haemodialyis. [144] Block copolymers of poly(ethylene oxide) and dextranconjugated polyamides were prepared by a quasiliving process.…”

Section: Reviewsmentioning

confidence: 99%

Developments in Membrane Research: from Material via Process Design to Industrial Application

et al. 2006

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The aim of this review paper is to give an overview of the research activities of GKSS in the field of polymer based membranes. After summarizing the historic development of membrane science at GKSS, it describes different classes of polymeric materials for membranes, and the characterization of membranes. The design of membrane‐based separation processes followed by examples of applications will also be presented. In the last chapter we will try to give an outlook for the future activities in membrane research.

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Section: Reviewsmentioning

confidence: 99%

Developments in Membrane Research: from Material via Process Design to Industrial Application

et al. 2006

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“…Nanoparticles prepared from poly(γ-benzyl-L-glutamate) (PBLG) and poly(ethylene glycol) (PEG) are a hydrophilic-hydrophobic diblock copolymer that have all of these characteristics [ 5 - 9 ]. PBLG, the hydrophobic moiety, is biodegradable and acts as a drug incorporation site [ 12 ]. PEG, the hydrophilic moiety, is a non-toxic, non-immunogenic hydrophilic polymer that prevents interactions with cells and proteins [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic characteristics and anticancer effects of 5-Fluorouracil loaded nanoparticles

Wang

Jiang

et al. 2008

BMC Cancer

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Background: It is expected that prolonged circulation of anticancer drugs will increase their anticancer activity while decreasing their toxic side effects. The purpose of this study was to prepare 5-fluorouracil (5-FU) loaded block copolymers, with poly(γ-benzyl-L-glutamate) (PBLG) as the hydrophobic block and poly(ethylene glycol) (PEG) as the hydrophilic block, and then examine the 5-FU release characteristics, pharmacokinetics, and anticancer effects of this novel compound.

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“…The 1 H‐NMR spectra were measured by a Bruker Unity‐300 NMR spectrometer at room temperature, with d 6 ‐DMSO as solvent and tetramethylsilane as internal reference. The molecular weight of the synthesized polymers was estimated at 35 °C in DMF solution by gel permeation chromatography (GPC) (apparatus: Water 515 American, velocity of flow: 1 mL min −1 , polystyrene standards) 22–26. The infrared spectra were also measured using an IR spectrometer (Nicolet 5DX FTIR).…”

Section: Methodsmentioning

confidence: 99%

Synthesis and characterization of polypeptide containing liver‐targeting group

Cha

et al. 2006

Polymer International

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Glycyrrhetinic acid, glycyrrhizic acid and bile acid were reported to be accumulated in liver. A series of novel liver-specific targeting polypeptides, poly(γ -benzyl-L-glutamate), were synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of γ -benzyl-L-glutamate (BLG-NCA) with amine-terminated compounds containing the above-mentioned liver-targeting group as an initiator. The molecular weights of the polypeptides were measured by gel permeation chromatography. The structures of these polypeptides and their initiators were confirmed by FTIR and 1 H-NMR spectroscopy. The results demonstrate that it is an efficient strategy to introduce a liver-targeting group into polymers via amine-terminated compounds containing glycyrrhetinic acid, glycyrrhizic acid and bile acid. The novel polymers have potential medical applications in targeted drug delivery.

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Surface properties and biocompatibility of A-B-A type block copolymer membranes consisting of poly(γ-benzyl-l-glutamate) as the A component and polyisoprene as the B component

Cited by 19 publications

References 13 publications

Developments in Membrane Research: from Material via Process Design to Industrial Application

Developments in Membrane Research: from Material via Process Design to Industrial Application

Pharmacokinetic characteristics and anticancer effects of 5-Fluorouracil loaded nanoparticles

Synthesis and characterization of polypeptide containing liver‐targeting group

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