Surface properties of intraocular lens materials and their influence on in vitro cell adhesion

Cunanan, Crystal; Tarbaux, Nanine M.; Knight, Patricia M.

doi:10.1016/s0886-3350(13)80409-9

Cited by 88 publications

(29 citation statements)

References 21 publications

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“…This mobility has been recognized in other biomaterial applications and is believed to be caused by primary (segmental backbone) and secondary (side chain) molecular motions [15,16].…”

Section: Sessile Drop Contact Angle Methodsmentioning

confidence: 99%

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Physicochemical Surface Properties of Various Intraocular Lenses

Dick¹,

Frohn²,

Augustin³

et al. 2001

Ophthalmic Res

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Purpose: It is of major interest to understand how intraocular lens (IOL) surfaces interact with aqueous humor or tissues after implantation. Important parameters to describe the physicochemical surface properties are the contact angle and critical surface tension. Therefore, we performed measurements of the contact angle and critical surface tension of several commercially available IOLs. Setting: Department of Ophthalmology, Johannes Gutenberg University, Mainz, University Eye Hospital, Tübingen, and Max Planck Institute for Polymer Research, Mainz, Germany. Methods: A total of 17 commercially available standard quality IOL types (6 of each) of different materials from several manufacturers were studied. Scanning electron microscopy and contact angle measurements using the sessile drop method were made. Results: The sessile drop method differentiated all materials based on their surface forces. The contact angle (mean ± SD) ranged from 56.5 ± 3.8b 3Conclusion: Contact angles differed between the IOLs depending on the IOL material with the lowest contact angle in the heparin-surface-modified IOL. The contact angle measurement method generates useful information about the material surface and its potential biomaterial interactions.

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“…This mobility has been recognized in other biomaterial applications and is believed to be caused by primary (segmental backbone) and secondary (side chain) molecular motions [15,16].…”

Section: Sessile Drop Contact Angle Methodsmentioning

confidence: 99%

“…The other silicones and flexible acrylics exhibited differences of 23-29°u nder these conditions [16]. It is important to consider the effects of the environment and molecular mobility when correlating surface properties to biological interactions.…”

Section: Sessile Drop Contact Angle Methodsmentioning

confidence: 99%

Physicochemical Surface Properties of Various Intraocular Lenses

Dick¹,

Frohn²,

Augustin³

et al. 2001

Ophthalmic Res

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“…However, there is a paucity of literature about HepG2 cells on unmodified PMMA (39) and no studies on epoxy resin as a tissue culture surface, though it has been used in the production of structured surfaces in PDMS, where epoxy was used as a mould master, providing improvement over the more commonly used etched silicon in terms of durability as shown by Kamande et al (35). PMMA is widely used as a material for intraocular lenses, especially in the developing world (40) and studies have been carried out on cell adhesion to intraocular lens materials (41). Human lens cells have been grown on pristine PMMA and PS surfaces but with significant modifications (42).…”

Section: Discussionmentioning

confidence: 99%

Cell morphology and growth observation studies on novel, chemically unmodified and patterned polymer surfaces for advanced tissue culture applications

Trease

Longman

Augousti

et al. 2017

Polymer

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Please cite this article as: Trease CH, Longman MR, Augousti AT, Foot PJS, Pierscionek B, Cell morphology and growth observation studies on novel, chemically unmodified and patterned polymer surfaces for advanced tissue culture applications, Polymer (2017), doi: 10.1016/j.polymer.2016.12.032. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT Electrohydrodynamic instability patterningPrinted polymer surfaces Cell Specific interactions. M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT AbstractCreation of more physiologically relevant cell models in tissue culture is a requisite for advancing medical research. It can involve complex substrates, expensive manufacturing and largely inaccessible methods of increasing surface energy and patterning of materials that may be unnecessary in manycircumstances. An array of various different adherent cell lines (human, mammalian, healthy and disease states) were grown on simple sterilised but otherwise untreated thin film surfaces as well as on electro-hydrodynamically patterned surfaces to produce topographically patterned culture surfaces.Room temperature cure epoxy resin and unmodified poly(methyl methacrylate) (PMMA) thin film surfaces were used for cell growth and morphological observations. Differing responses in growth, morphology and adherence were observed in a surface-and cell-specific manner. With no complex and expensive modifications required, we demonstrate the application of novel, suitable and easily patterned materials for use in more advanced tissue culture applications for a variety of clinically relevant cell lines showing unique responses and potentially new and wide-reaching applications.

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“…The numbers of adherent cells on acrylic lenses were the highest, those of silicone lenses were the least, and there was no significant difference between the cells on PMMA and silicone IOLs (P>0.05). Cell adhesion to IOLs is supported by their surface properties, different protein adsorption characteristics [11], and the interfacial energy of the material [4]. Since we used serum-free medium for a 30 min attachment assay, protein adsorption from media should have been minimal.…”

Section: Discussionmentioning

confidence: 99%