Heat transfer characteristics of R410A condensation in horizontal tubes with inner diameter of 3.78 mm under normal and reduced gravity are investigated numerically. The mass transfer model and numerical methods are validated by comparing the numerical heat transfer coefficients under normal gravity with the experimental work and empirical correlations. The results indicate that the heat transfer coefficients increase with increasing gravitational accelerations at a lower mass flux, while the difference of these under varing gravity is insignificant at a higher mass flux. The liquid film thickness decreases with increasing gravity at the top part of the tube at vapor quality x = 0.5 and 0.9, while the reverse is true for that at the tube bottom. The average liquid film thickness is nearly the same under different gravity accelerations at the same vapor quality and mass flux. The local heat transfer coefficients increase with increasing gravity at the top of the tube and decrease with increases in gravity at the bottom. The proportion of the thin liquid film region is important for the overall heat transfer coefficients for the condensing flow. A vortex with its core lying at the bottom of the tube is observed under normal gravity because of the combined effect of gravity and the mass sink at the liquid-vapor interface, while the stream traces point to the liquid-vapor interfaces under zero gravity. The mass transfer rate under zero gravity is much lower than that of normal gravity.